SYSTEMIC CONNECTIVE TISSUE DISEASE

Question 1

WHAT IS COLLAGENOUS DISEASE KNOWN AS?

Answer 1

describes systemic autoimmune disease affecting the connective tissue

there are 7 groups of collagenous disease

Question 2

HOW MANY GROUPS OF COLLAGENOUS DISEASE? OUTLINE THEM?

Answer 2

7 GROUPS

1. SYSTEMIC LUPUS ERYTHEMATOUS
2. RHEUMATOID ARTHRITIS
3. SCLERODERMIA
4. POLYMIOSITIS-DERMATOMYOSITIS
5. RHEUMATISM
6. POLYARTERITIS
7. SJOGRENS SYNDROME

Question 3

DEFINE RHEUMATISM

Answer 3

also known as Rheumatic fever:

> systemic
> recurrent 
> nonsuppurative
> allergic inflammatory 
complication of untreated pharyngeal infection with group A P-hemolytic streptococci 

characterised by inflammatory lesions in:
> heart
> joints
> subcutaneous tissue

Question 4

CHARACTERISTICS OF RHEUMATISM

Answer 4

Inflammatory lesions in:
> heart
> joints
> subcutaneous tissue

Question 5

WHICH ORGANS DOES ACUTE RHEUMATIC FEVER AFFECT?

Answer 5

> carditis 
> poly-arthritis
> chorea minor 
> skin lesions
> subcutaneous rheumatic nodules

Question 6

WHICH PATHOGEN IS THE CAUSATIVE AGENT FOR RHEUMATIC FEVER

Answer 6

GROUP A B-HEMOLYTIC STREPTOCOCCI

Question 7

WHAT IS CHOREA MINOR AND WHAT IS ANOTHER NAME FOR IT?

WHAT IS THE CAUSATIVE AGENT?

Answer 7

Sydenham’s Chorea
> disorder with rapid, uncoordinated, jerking movements mainly affecting face, hand and feet
> involvement of basal ganglia of the brain

CAUSATIVE AGENT?
> group A B-hemolytic streptococci
> mostly those with rheumatic fever will get Sydenham’s chorea (chorea minor)

Question 8

DESCRIBE SUBCUTANEOUS RHEUMATIC NODULES?

Answer 8

> mainly occur over bony prominence in the extremities

> pea sized
non-tender
last 6-10 weeks