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Flashcards in Systemic JIA Deck (30)
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1
Q

what is the most common chronic rheumatic disease of childhood?

A
  • JIA
2
Q

criteria for dx of JIA

A
  • < 16 years old

- arthritis in 1 or more joints for > 6 weeks

3
Q

is there a specific laboratory test for dx of JIA

some lab findings

A
  • no
  • increased WBCs
  • normocytic, hypochromic anemia
  • increased ESR and CRP
4
Q

oligoarthritis is how many joints

onset age

affects males/females

which extremities

prognosis for outgrowing

A

< 4 joints

  • between 1-2 years old
  • females
  • affects lower extremities (knee or ankle)
  • good prognosis for outgrowing
5
Q

patients with JIA may present with which eye pathology

unlateral or bilateral

which subtype of JIA is most likely to get it

A
  • uveitis
  • bilateral
  • oligoarthritis
6
Q

frequency of eye exams determined by duration of disease and ______ antibody status

A
  • ANA

- eye exams every 3 months

7
Q

polyarthritis affects how many joints

RF pos/neg - which one most common

how likely are children to outgrow it?

A

> 5

  • RF neg most common
  • less likely
8
Q

RF negative polyarthritis has a peak onset of what age

what sex more affected

affects what parts of body

A
  • 1-3
  • through adolescence
  • female
  • knees, wrist, ankles
9
Q

RF positive polyarthritis has a what other antibody present

A
  • anti-CCP
10
Q

RF positive polyarthritis peak onset

what sex most involved

what is the remission late

A
  • 9-11
  • females

very low

11
Q

RF positive polyarthritis involves what joints

symmetric/asymmetric

A
  • large/small joints
  • upper/lower extremities
  • symmetric
12
Q

rheumatoid factor antibodies bind the ___ portion of Ig_

most common antibody that is RH factor

A
  • Fc portion of IgG

- IgM

13
Q

what is a predictor of disease course in JIA

more/less aggressive disease

A
  • rheumatoid factor

- more aggressive disease

14
Q

anti-CCP Ab is specific for which condition and may be a predictor for its disease course

A
  • rheumatoid arthritis
15
Q

enthesitis related arthritis is associated with which HLA

A
  • B-27
16
Q

enthesitis related arthritis has what age of onset

affects which sex

symmetric/asymmetric joint involvement

A
  • late childhood/adolescence
  • males more
  • asymmetric
17
Q

which form of arthritis presents with sacroillitis with or without spondylitis

A
  • enthesitis related arthritis
18
Q

juvenile psoriatic arthritis has what additional conditions besides arthritis and psoriasis

A
  • dactylitis (sausage digit)
  • nail pitting/onycholysis (psoriasis of nails)
  • psoriasis in a first degree relative
19
Q

cause of systemic JIA

A
  • phagocytic dysregulation
  • overproduction of pro-inflammatory cytokines
  • aberrant activation of phagocytes
20
Q

criteria of dx for systemic JIA

A
  • fever > 2 weeks duration with at least 3 days quotidian
  • arthritis in any joint for at least 6 weeks
    ANY OF THE FOLLOWING
  • salmon-pink macular rash, migratory
  • generalized lymphadenopathy
  • splenomegaly/hepatomegaly
  • serositis
  • leukocytosis
  • anemia
21
Q

are autoantibodies common for systemic JIA

A
  • no
22
Q

major cause of death in secondary amyloid as a result of JIA

A
  • renal failure
23
Q

MOA of Anakinra

used to treat

A
  • IL-1 inhibitor
  • competes with IL for binding to receptor
  • JIA
24
Q

MOA of Canakinumab

used to treat

A
  • IL-1 inhibitor
  • directly targets IL-1
  • JIA
25
Q

majority of inflammatory diseases are due to IL-___ activity

A
  • IL-1
26
Q

side effects of IL-1 inhibitors

A
  • increased risk of infections

- cytopenias

27
Q

do you give live viral vaccines with IL-1 inhibitors

A
  • no
28
Q

signaling only initiated when IL-6-IL-6-R complex associates with ____

signaling then initiated via ______ pathway

A
  • gp130

- JAK-STAT

29
Q

adverse affects of Tocilizumab

this drug is used for what conditions

A
  • increased risk of infections
  • changes in blood cell counts
  • liver toxicity
  • RA/JIA
30
Q

which sex gets systemic JIA more

A
  • equal among sexes