Flashcards in Systemic Lupus Erythematosus Deck (7):
What are the risk factors of SLE?
- age 15 - 45
- African/Asian decent
Pathophysiology of SLE
IgG antibodies to dsDNA and nuclear (ANA = anti nuclear antibodies)
What are the three main rashes that occur in SLE?
- Malar rash: erythema over the cheeks and bridge of nose, sparing the nasolabial folds
- Photosensitive rash: Rash occurs after sun exposure. It can be painful and pruritic and usually lasts a few days, healing without scarring
- Discoid rash: Erythematous raised patches with adherent keratotic scaling and follicular plugging. This is the chronic rash
Outline the articular features of SLE
Non - destructive, non-deforming polyarthritis i.e. REVERSIBLE (with fist, prayer and reverse prayer)
What are the common extra-articular features of SLE?
- The 3 rashes: malar, photosensitive and discoid
- Weight loss
- Oral ulcers
- Pleuritis and pericarditis (serositis)
- Renal impairment (proteinuria)
- Raynaud's Phenomenon
- abdo pain, n/v
How do we diagnose SLE?
FBE: anaemia, leukopaenia, thrombocytopaenia
Serology: ANA, anti-dsDNA
ESR and CRP elevated
Urinalysis: protein, red casts