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General Systemic > Toxicology > Flashcards

Flashcards in Toxicology Deck (14):
1

What are the most common two drug overdoses?

1. Paracetamol2. Quitiapine (seroquel)Other:AlcoholDigoxinBenzoOxycodone

2

What are the management options for drug OD?

• Decrease absorption: charcoal, stomach pump, whole bowel irrigation (life threatening) • Physiological antagonist: atropine for organophosphate• Bicarbonate: aspirin OD; anticonvulsants OD; sodium channel blockers• Direct antagonist:• Antidote: naloxone

3

Pathophysiology of paracetamol toxicity

Depletion of glutathione anti-oxidant leads to NAPQI produced leading to hepatocellular necrosis

4

What paracetamol dose can lead to toxicity?

> 400mg/kg

5

What is the antidote for paracetamol toxicity?

• Antidote 100% effective if started within 8 hours: N-acetylcysteine (NAC)o IV infusiono Weight based infusion, independent of how much was takeno AFx: anaphylactic

6

How do you manage a toxicology patient?

Supportive care for 95% of cases (ABCDE * mainly breathing), assess by GCS.Usually wait for it to wear off if between 11-13 GCS.If GCS

7

How does a SSRI OD present?

Massive clonusNystagmus

8

What are the mechanism of toxicity of venomous creatures of Australia?

Neurotoxicity (muscle paralysis - normally just keep them on ventilation until toxic leaves)CardiotoxicityEye

9

How do you die from brown snake?

Coagulopathy (DIC pattern) - massive bleeding from every orifice

10

Rx of snake bites

Antidote

11

Ix of snake bites

Venom detection kit * but do not go on the results of this, go on the clinical signs

12

Most lethal animal?

Box jelly fish: cardiotoxic causing asystole within minutes

13

Common spiders

Funnel web spider (mostly in NSW)Red-backs (doesn't actually kill; severe pain)

14

Irikanji MoA?

irikanji - catacholamine surge, fatal in IHD patients