Systemic Response to Injury Part 2 Flashcards
Seven identified chromatin modifications:
Acetylation Methylation Phosphorylation Ubiquitinylation Sumoylation ADP ribosylation Deimination Proline isomerization
The role of histone modifications in the regulation of gene expressions is referred to:
Epigenetic control
Pretreatment of this antagonist reduce the expression of selected inflammatory genes in LPS activated macrophages. Also confers protection against bacteria induced sepsis.
I-BET ( a synthetic compound)
Important translational regulator of gene expression via their binding to partially complementary sequences in 3’ untranslated region. It also suppress the expression of NF-KB target genes such as IL-6, IL-8, IL-1B and TNF a.
microRNAs (miRNAs)
Small, circulating fragments of megakaryocyte, that plays a role in hemostasis and in both local and systemic inflammatory response following ischemia reperfusion.
Platelets
Th lymphocytes:
Recognition and killing of intracellular pathogens (cellular immunity) (pro inflammatory)
Th1 cells
Th lymphocytes:
Regulation of antibody production ( humoral immunity) (anti inflammatory)
Th2 cells
Th lymphocytes:
Maintenance of mucosal immunity and barrier integrity
Th17 cells
Known inhibitors of Th1 response
IL-4 and IL-10
Known inhibitor of Th2 response
Interferon-Y
Decreased in production of this IL by activated macrophages, has been associated with increased risk of infectious complications following surgery and trauma
IL-12
Have immune suppressive activity through increased expression of arginase that potentially deplete the microenvironment of arginine, leading to further T cell dysfunction
Myeloid derived suppressor cells
Frequently referred to as “professional APCs” since their principal function is to capture, process and and present both exogenous and endogenous antigens, capable of inducing primary immune response in resting naive T lymphocyes
Dendritic cells
Immunocytes whose primary function are antihelminthic. Activated by IL-3, IL-5,GM-CSF, chemoattractants and PAF.
Eosinophils
Located in the tissues and plays an important role in anaphylactic response to allergens and TNF Release for neutrophil recruitment and pathogen clearance
Mast cells