T cell recognition

Question 1

trans-membrane structure, two chain, variable and constant regions

Answer 1

TCR

Question 2

TCR always expressed on the surface expressed with _____ and ________

Answer 2

CD3+ and Zeta

Question 3

signal transduction molecules—> transfer signal from outside to inside and change message into the nucleus

Answer 3

CD3+ and Zeta

Question 4

TCR Short Cytoplasmic tails thus

Answer 4

cannot transmit messages

Question 5

can be used as a marker because it exist on all T cells

Answer 5

CD3+

Question 6

C19/C20 marker for

Answer 6

mature B cell

Question 7

intracellular portion, important for T cell signaling

Answer 7

Signaling molecules

Question 8

this sign says that the gene is expressed

Answer 8

+

Question 9

causes difference in function because their respective function do not overlap

Answer 9

alpha/beta and delta/gamma

Question 10

uptake function by T cells

Answer 10

infection, endocytosis and phagocytosis

Question 11

cell-mediated

Answer 11

T cell

Question 12

humoral

Answer 12

AB- B cell

Question 13

three way interaction between

Answer 13

MHC on host cell with peptide derived from antigen with T cell

Question 14

expressed on all nucleated cells

Answer 14

MHC I

Question 15

expressed constituitively only on antigen presenting cells

Answer 15

MHC II

Question 16

APC cells

Answer 16

Dendritic, macrophages and B cells

Question 17

interact with CD8

Answer 17

MHC I

Question 18

interact with CD4

Answer 18

MHC II

Question 19

coreceptors on alpha/beta TCR t cells

Answer 19

CD4 and CD8

Question 20

specific adhesion molecules and tighten the interaction between t cells and peptide with the host cell

Answer 20

CD4 and CD8

Question 21

they enhance the signal transduction through the TCR

Answer 21

CD4 and CD8

Question 22

binds to HIV

Answer 22

CD4

Question 23

CD4 and CD8 are not just found in

Answer 23

T cells but APC cells as well

Question 24

killer or cytotoxic T cell

Answer 24

CD8

Question 25

T helper, cytokine synthesis (Tregs)

Answer 25

CD4

Question 26

antigen recognition= TCR

Answer 26

alpha/beta and delta/gamma

Question 27

signal transduction

Answer 27

CD3 and zeta

Question 28

corereceptor

Answer 28

CD4 and CD8

Question 29

T cell development occurs in the

Answer 29

thymus

Question 30

where you develop the receptor specific for antigen

Answer 30

primary lymphoid organs

Question 31

after puberty what happens to the thymus?

Answer 31

shrink and little production of T cells

Question 32

thymus is absent or underdeveloped leading to no mature T cell and thus prone to recurrent infections as a young child

Answer 32

Di George

Question 33

developing T cells

Answer 33

Thymocytes

Question 34

Common lymphoid progenitor once reaching the thymus is considerd

Answer 34

double negative cell

Question 35

double negative cell is

Answer 35

not expressing any T cell characteristics

Question 36

gamm/delta do not respond to

Answer 36

peptide + MHC

Question 37

bridge between the innate and adaptive response

Answer 37

gamma/delta

Question 38

major pathway of the thymus

Answer 38

alpha/beta

Question 39

double positive thymocyte expresses both

Answer 39

alpha/beta and CD4+ and CD8+

Question 40

process of generating T cell is

Answer 40

random

Question 41

site of positive selection

Answer 41

cortex

Question 42

site of negative selection

Answer 42

medulla

Question 43

in positive selection what is needed for T cells to survive?

Answer 43

interaction with my corticol epithelial cells

Question 44

education in positive selection leads to interaction of mature T cells

Answer 44

only seen with that MHC that they encountered during development

Question 45

lineage choice leads to expression of either

Answer 45

CD4 or CD8 (CD4 is more lucrative 2x over)

Question 46

negative selection explains that for the T cells that survived Positive selection they have to show

Answer 46

low affinity for dendritic self cells to survive

Question 47

failure of negative selection

Answer 47

autoimmune disease

Question 48

APECED

Answer 48

multi-organ system affected

Question 49

a flu hemagglutinin peptide + HLA-DP2

Answer 49

CD4 T597

Question 50

an ebola peptide + HLAB3

Answer 50

CD8 T1461

Question 51

measles petide + HLADR4

Answer 51

CD4 T 8052

Question 52

A flu hemagglutinin peptide + HLA A2

Answer 52

CD8 T17