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122 E03 > T02 Enteropathogenic Bacterial Infections > Flashcards

T02 Enteropathogenic Bacterial Infections Flashcards

1
Q

inflammation of what two organs lead to infectious enterocolitis

A

small intestine, colon

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2
Q

Etiology of entercolitis varies depending on

A

age, nutrition, host immune status, environmental influences

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3
Q

T/F RAN (Rota, Adeno,Noro) are the only viral agents of infectious enterocolitis

A

T

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4
Q

pathogenesis: Adhesion and Local proliferation (2) produce exotoxins

A

ETEC, V cholera

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5
Q

pathogenesis: Adhesion and Mucosal Invasion (4) SECS

A

S enterica, E histolytica, C jejuni, Shigella

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6
Q

Highjacking host pathways (usually Salmonella, Shigella)

A

M cells

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7
Q

Diarrhea ins increase in stool __, __, __

A

mass, frequency, fluidity

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8
Q

Dysentery

A

bloody, small volume diarrhea caused by SES

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9
Q

Bristol Stool Chart

A

Visual aid in evaluating diarrhea in patients

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10
Q

Diarrhea ISOTONIC stool that PERSISTS with fasting; due to INFECTION

A

Secretory Diarrhea

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11
Q

Diarrhea 50 mOsm, concentrated than plasma; RELIEVED with FASTING; due to excessive osmotic forces by Luminal salts (Ex. disaccharidase deficiency)

A

Osmotic Diarrhea

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12
Q

Steatorrhea, SUBSIDES with fasting, Problems w nutrient absorption

A

Malabsorptive Diarrhea

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13
Q

Purulent/Bloody stools due to inflammatory diseases; PERSISTS with fasting;

A

Exudative Diarrhea

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14
Q

non-invasive, within lumen Gram neg comma shaped bacterium with distinct flagella sa SHELLFISH, AND PLANKTON

A

V chloera

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15
Q

Virulence factors of Cholera

A

Cholera toxin, Flagella, Hemagglutinin

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16
Q

A subunit in Cholera is released to ER by

A

Retrograde transport

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17
Q

Why does the reeased fragment of A subunit go back to configuration

A

to prevent degradation

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18
Q

A subunit binds to this to activate Adenylate Cyclase (doggy lol ARF)

A

ADP-ribosylation factor

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19
Q

Activation of adenylate cyclase results to increased

A

Intracellular cyclic adenosine monophosphate

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20
Q

Accumulations of which lead to osmotic driving froce that draws water into lumen

A

sodium, chloride, bicarbonate

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21
Q

Most common pathogen in developed country transmitted thru poultry, milk, other foods; also EnRa (Erythema nodusum, Reactive arthritis)

A

Campylobacter jejuni

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22
Q

when C jejuni proliferates in lamina propria, mesenteric lymph nodes

A

Enteric fever

23
Q

40% of C jejuni cases, due to molecular mimicry (SPINAL CORD similar antigens); FLACCID PARALYSIS

A

Guillain-Barre syndrome

24
Q

C jejuni pathogenesis

A

Cholera toxin-like ENTEROTOXIN; Flagella, Invasion

25
Q

T/F C jejuni has specific histology

A

F, nonspecific

26
Q

T/F Antidiarrheals should be given to people with shigellosis

A

F, prolong symptoms

27
Q

Reservoir of Shigella

A

Humans only

28
Q

Shigella is facultative anaerobe

A

T

29
Q

Reiter Syndrome and HUS are complications under

A

Shigellosis

30
Q

Why is Shigellosis more prominent in the left colon

A

M cells are found in the left colon

31
Q

Differential diagnosis of Shigellosis

A

Crohn’s Disease

32
Q

Virulence factor Shiga toxin inhibits ___ synthesis and is released by serotype __

A

protein, 1

33
Q

Disseminated salmonellosis occur in patients with

A

defects of TH17 immunity

34
Q

Which is not a virulence factor of Salmonella: Flagellin, Hemagglutinin, T3SS, Lipopolysaccharide

A

Hemagglutinin

35
Q

Slightly raised erythematous lesions on chest and abdomen that are manifestations of Typhoid fever

A

Rose spots

36
Q

T/F Salmonellosis and Typhoid fever both have contraindications for Antibotic treatment

A

F, only Salmonellosis

37
Q

They can survive in gastrc acd, invade M cells, and sometimes cause gall stones

A

S typhi

38
Q

Typhoid nodules

A

necrosis in the liver with hepatocytes

39
Q

Enlarged peyers patches, Splenomegay with phagocyte HYPERPLASIA; Neutrophils in superficial lamina propria

A

Typhoid fever

40
Q

Mimics the symptoms of acute appendicitis in teenagers due to invasion of Peyer’s patches

A

Yesinia

41
Q

Invades M-cells

A

SYS

42
Q

enteritis and colitis are caused in young children by

A

Yersinia

43
Q

___ increases virulence and systemic dissemination of Yersinia

A

Iron

44
Q

Causative agent of Traveler’s diarrhea; 2 toxins: LT,ST; Binds to GUANYLATE CYCLASE

A

ETEC

45
Q

attaching mechanism of the microvilli ang virulence

A

EPEC

46
Q

Cows natural reservoir, mainly O157:H7; Shiga-like toxin

A

EHEC

47
Q

No toxin but INVADES epithelium

A

EIEC

48
Q

Fimbria and Dispersin as virulence

A

EAEC

49
Q

Clostridium difficile causes this

A

Pseudomembranous colitis

50
Q

Treatment of PC

A

Metronidazole, Vancomycin

51
Q

Volcanic eruptions, Pseudomembranes

A

Clostridium difficile

52
Q

Foamy macrophages w/ PAS positive, diastase resistant granules

A

Whipple disease

53
Q

Gram + actinomycete; common in caucasians; AFB used to differentiate from Mycobacteria

A

Tropheryma whippelil

54
Q

Triad of symptoms whipple disease (DAW)

A

Diarrhea, Arthralgia, Weight Loss

122 E03 (4 decks)

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