T2- MISC Flashcards

1
Q

increase susceptibility to UV damage

A

loss of NER

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2
Q

increase metastasis

A
  • loss of KAI1

- loss of E-cadherin

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3
Q

decrease metastasis

A
  • NM23
  • CD44 involved with cell adhesion
  • CD82 induced by p53
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4
Q

anti-apoptosis

A
  • decreased cytochrome c release from mitochondria:
    a) Bcl2–> blocks channels made by BAX/BAK dimers
    b) Bcl-xl–> binds to BAX/BAK to prevent their self association
  • decrease caspase activation–> XIAP: ubiquitination of capsize 3
  • promotes cell survival
  • AKT (PKB) when over activated in cancer cells contributes to decreased apoptosis.
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5
Q

pro-apoptosis

A
  • activation of cytochrome c with APAF1
  • increase cytochrome c release from mitochondria
  • dimerization of bax and bak.
  • TRADD activation
  • mitochondrial release of SMAC by bid
  • SNAIL stabilizes AIF to expand its half life and promote apoptosis
  • activation of MOAP1 promotes apoptosis of BAX
  • endonuclease G is a caspace-independent apoptosis
  • BAD is a pro-apoptotic unless phosphorylated by AKT
  • BID is pro-apoptotic and activated BAX and BAK
  • TRAIL activated apoptotic signal
  • PUMA promoted apoptosis and is unregulated by p53
  • BAX activated by p53 to promote apoptosis
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6
Q

increases transcription

A
  • LMP1 increases transcription bcl-2
  • EBNA-2 increases transcription cyclin D
  • STAT5 increases transcription e-cadherin
  • E2F-DP1 increases transcription for S phase proteins
  • Nf-kB increases transcription for inflammation and cell growth
  • MYC when bound to MAX promotes transcription
  • twist promotes transcription of n-cadherin
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7
Q

decreases transcription

A
  • SNAIL inhibits transcription of E-cadherin
  • MAD when bound to MAX inhibits transcription
  • GROUCHO bind TGF and is involved inhibiting TCF4 transcription
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8
Q

increases ubiquitination (tagged for degradation) of p53

A
  • HPV-E6
  • MDM2
  • HDM2
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9
Q

diminishes p53 activity

A

HPV-E6

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10
Q

promotes EMT

A
  • FOXC2
  • hypermethyllation of e-cadherin gene
  • TWIST upregulation is associated with EMT
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11
Q

Angiogenesis

A
  • decreases with loss of HIF-1

- increased when there is a deleted or suppressed PKG

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12
Q

telomere

A
  • increases rebuilding potential: loss of TRF-1

- premature aging typically associated with telomere erosion

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13
Q

rate of G1–> S transition

A
  • increases rate: loss of P14-ARF

- reduces the latency: loss of Rh

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14
Q

cell growth

A
  • increase: active mTOR

- AKT (PKB) when over activated in cancer cells.

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