T2DM Flashcards
(12 cards)
1
Q
Treatment
A
Not at high CVD risk
* Metformin
If HbA1c still uncontrolled, add either:
* SGLT2i
* DDP4i
* Sulfonylurea
* Piolitazone
High CVD risk
* Metformin, then add SGLT2i
If HbA1c still uncontrolled, add either:
* DDP4i
* Sulfonylurea
* Piolitazone
2
Q
SGLT2i
A
“Flozin”
Dapagliflozin, Canagliflozin, etc.
3
Q
SGLT2i cautions
A
- Life-threatenin DKA!
Monitor ketones if treatment is interrupted (surgery/ illness) - Fournier’s gangrene
- Risk of lower-limb amputation (Canagliflozin)
- UTIs
4
Q
DDP4i
A
“Liptin”
Alogliptin, Linagliptin, etc.
5
Q
DDP4i cautions
A
Pancreatitis
6
Q
Sulfonylurea
A
Gliclazide
7
Q
Sulfonylurea cautions
A
- Hypolycaemia
8
Q
Metformin cautions
A
- Withold in AKI! (Lactic acidosis)
Caution in eGFR <30 - GI disturbances
9
Q
Pioglitazone warnings
A
- Avoid in patient’s with heart failure
Increased risk of:
* Bladder cancer
* Bone fractures
* Liver toxicity
10
Q
Which antidiabetics cause weight gain?
A
- Sulfonylureas
- Pioglitazone
11
Q
Which antidiabetics cause weight loss?
A
- GLP1
- SGLT2i
12
Q
Which antidiabetics are weight-neutral?
A
- Metformin
- DDP4i
