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Flashcards in Tablet Deck (16)
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1

Tablets properties

1) have exact dosage of active principles
2) confer maximum stability possible
3) contain only inert additives/excipients
4) aesthetically pleasing
5) suitable for its intended purpose

2

Tablet advantage

1) convenient means of administering
2) delivery an accurate dose
3) small and compact
4) stable product
5) easy to handle and pack
6) high production throughput possible

3

Tablet disadvantage

1) poor compressibility
2) poor wetting
3) slow dissolution
4) high dose
5) bitter taste / bad odour
6) sensitivity to mositure

4

improve tableting output

1) increase the effective number of punches per station by multi-tip punches

2) increase rate of compression (turrent speed)

3) number of points of compression
4) increase number of stations, segmented die.

5

segregation increases when ________

there is a large difference in form, size, and or density of the particles.

6

ensure powder flowability

to ensure
- tablet weight uniformity
- tablet with consistent and reproducible properties.

7

Mechanism strength of tablets depend on

1) Particle size, distribution and shape
(small size = UP SA = more bonding = more strength)

2) granule porosity (no pore = high strength; initial more pore => after compression = higher strength)

3) Moisture content (dry = less strength)

4) Fragmentation and visco-elastic deformation
5) applied load (compaction force)
6) time of loading (strain rate sensitivity)
7) time of unloading (strain rate sensitivity)
8) elastic stress release upon ejection

8

Excipients affecting compaction properties

1) diluent/filler
2) binder/adhesives
3) lubricants, glidants, antii-adherent.

9

Excipients affecting bioavailability, stability, marketing

1) lubricant
2) disintegrant
3) colorant, flavours, sweeteners.

10

Diluent/fillers

Sugars
starch
celluose
inorganic salt

11

binder

cellulose
modified celulose (HPMC etc)
synthetic polymer (PVP etc)
Gums

12

mechanism of disintegration

swelling
wicking
straining recovery
interruption of particle particle bonds
heat of interaction

13

glidant

silicates
fused silica (cab-o-sil,aerosil, syloid)
starch
talc
Mgst, carbonate, oxide
Cast
Znst

14

Disintegrants

Starch
Cellulose
gum
synthetic polymer

15

lubricants

hydrodynamic (fluid type)
- mineral oil / paraffin

boundary (solid) type
- water insoluble
MgSt, CaSt, stearic acid, waxes amd hydrogenated oil

- water soluble
PEG, Na benzoate, Na acetate, leucine, SDS

16

antiadherent

silicates
starch
talc
Mg,Ca,Zn stearates
leucine
SDS