TB Flashcards

1
Q

immunocompromised, HIV or AIDS, crowded places (dormitory, nursing home, etc), alcohol addiction, any condition than makes you more immunocompromised

A

risk factors for TB

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2
Q

droplet nuclei containing tuberculosis bacilli are inhaled and enters the lungs where it travels to the ______, the bacilli multiply in the alveoli and then a small number enter the blood stream and start affection other areas of the body BRAIN, LARYNX, LYMPH NODES, LUNGS, SPINE, BONE , KIDNEYS. these organs and areas are affected too

A

alveoli

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3
Q

Infectious disease that primarily affects the lung parenchyma
May be transmitted to any organ through the blood (meninges, kidneys, bones and lymph nodes)
Primary infectious agent = Myobacterium tuberculosis
acid fast aerobic rod
grows slow, sensitive to heat and UV light

A

Tuberculosis

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4
Q

after its been in the blood for 2 to 8 weeks, macrophages will ingest and surround the bacteria, macrophages will develop a barrier shell called a ______ and prevents the BACTERIA FROM MULTIPLYING, THIS IS LATENT TB. if macrophages cant keep it under control, the TB will spread

A

granuloma

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5
Q

: will have a small amount of TB bacteria in body that are alive, but inactive. does not feel sick, does not have symptoms. can become sick though if their immune system becomes compromised.

A

LATENT

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6
Q

: large amount of TB in body and is _____. will feel sick.

A

active TB

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7
Q

will have a normal chest X ray, will have a negative sputum culture. may be treated prophylactic. is not on respiratory isolation. A person with latent TB case will not be identified as a TB case, a positive skin test will be reported but from there it is the Health Department that will decide about classification.

A

latent

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8
Q

will have an x ray that shows up. will definitely be treated. will be on respiratory isolation.

A

Active:

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9
Q

In frequent and close contact with an untreated individual
Who are immunocompromised (HIV, chemo)
Living in crowded facilities (prisons, long term care)
From a lower socioeconomic status
Who are homeless
Who are immigrants from countries with a high incidence of TB

A

common risk factors for TB

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10
Q

Low grade fever, cough, night sweats, fatigue and weight loss
Cough
Non-productive
Mucopurulent sputum may be expectorated
Both systemic and pulmonary symptoms are chronic
May be present for weeks to months

A

s/s of tb

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11
Q

_________ are like a distinguishing thing about TB apparently

A

NIGHT SWEATs

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12
Q

progressive fatigue
malaise
anorexia
weight loss
chronic cough (productive)
nigh sweats
hemoptysis
pleuritic chest pain
low grade temp

A

s/s of tb

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13
Q

Usually present with less pronounced symptoms than younger patients
May have unusual behavior and altered mental status, fever, anorexia and weight loss
Often the ______ will produce no reaction

A

TB skin test

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14
Q

extraplumonary disease is seen in up to 16% of cases in the US and is where the disease is seen in other areas of the body. this is mostly seen in?

A

AIDS patients

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15
Q

Complete health history
healthcare worker, travel, crowded conditions
Physical examination
Tuberculin skin test
Chest x-ray
Acid-fast bacillus smear
Sputum culture

A

diagnostic tools for TB

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16
Q

A TB skin test is also known as a ____ test but there is also a faster _____ test

A

Mantoux, nucleic acid amplification test

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17
Q

Chest x-ray usually reveals lesions in the upper lobes
Acid-fast bacillus smear contains mycobacteria
Fever, anorexia, weight loss, night sweats, fatigue, cough and sputum production
If the above are present, assess lungs for consolidation by evaluating breath sounds, fremitus and egophony

A

for a patient with active TB

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18
Q

Mantoux method
Used to determine whether the person has been infected with the TB bacillus
Intracutaneous injection using PPD (purified protein derivative) into the intradermal layer of the inner aspect of the forearm using a tuberculin syringe
Dose = _____
Test is read ______ hours after administration

A

0.1ml, 48-72

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19
Q

A positive reaction occurs when both _____ and ____ are present

A

erythema and induration

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20
Q

t/f: Erythema without induration is not significant

A

true

21
Q

Enzyme-linked immunosorbent assay (ELISA) that detects the release of interferon-gamma by white blood cells when the blood of the patient with TB is incubated with peptides similar to those in M. tuberculosis
Indicates whether the person has been infected, NOT whether or not the person has active progression of the disease

A

QuantiFERON-TB Gold Test

22
Q

Antituberculosis agents for ______ months

A

6-12

23
Q

Promoting Airway Clearance
Advocating Treatment Regimen
Promoting Activity and Nutrition
Preventing Transmission

A

nursing management for TB

24
Q

Of the approved drugs, INH, RIF, EMB, and PZA are considered the ______ anti-TB drugs and form the core of standard treatment regimens.

A

first-line

25
Q

___ month treatment plan is most common

A

six

26
Q

What foods do you need to avoid if youre taking INH?

A

tyramine

27
Q

What are the common first line treatments for TB?

A

INH
RIF,
EMB
PZA

28
Q

______can alter the metabolism of certain medications, making them less effective
May also discolor contact lenses

A

Rifampin

29
Q

Hepatitis, neurologic changes (hearing loss, neuritis), rash

A

side effects of all drugs for TB

30
Q

you get headaches, flushing, hypotension, light headedness, palpitations and diaphoresis with tyramine if taking ____

A

INH

31
Q

First oral drug against TB
Primary antitubercular drug
May induce liver damage
Used in combination with other drugs to treat active TB due to resistance
Interferes with lipid RNA and DNA synthesis in the tubercle bacilli
Bacteriostatic and acts specifically in tubercle bacilli
Can be bactericidal in higher doses

A

isoniazid

32
Q

Side/Adverse Effects
N/V, constipation (DIARRHEA)
Liver damage
HEPATITIS, LIVER FAILURE –MORE OFTEN SEEN IN OLDER ADULTS AND ALCOHOLICS
ast alt, jaundice
Peripheral neuropathy
MORE COMMON WITH ALCOHOLICS AND DIABETICS
can be given b 6, pyridoxine
CNS symptoms
dizziness, ataxia, seizures, psychotic symptoms

A

isoniazid

33
Q

Administration
Tablet or oral syrup or combination
Give oral drug on empty stomach (1 hour before meals)
Give IM dose in large muscle mass and rotate sites
If IM dose forms crystals, warm it to room temperature before administration
Give in combination with other TB meds to reduce resistance in active TB
Give Isoniazid alone for latent TB (6-9 month treatment)
Stay on Treatment!!!

A

isoniazid

34
Q

Tell patients…
To help with GI symptoms, take with food
Report severe GI symptoms to provider
Increase fiber and fluids to prevent constipation
Report jaundice, abdominal pain and unusual fatigue
Report numbness, tingling and pain in hands and feet
Report CNS symptoms

A

isoniazid

35
Q

Contraindications
Allergy to
SeveHistory of liver damage from _____
re liver damage
Precautions
Chronic liver disease, hepatitis
HIV infection
Adults greater than 50
Seizure disorders
Renal disorders
Alcoholism

A

isoniazid

36
Q

Suppresses protein synthesis
Bacteriostatic with some bactericidal activity against gram positive and gram negative bacteria
Also effective against organisms responsible for leprosy and meningitis
Available in IV or oral form

A

rifampin

37
Q

Can cause liver toxicity (hepatitis)
Expect red-orange color of bodily fluids including urine, saliva, tears and sweat
N/V, diarrhea, cramping and abdominal pain
Can make oral contraceptives less effective

A

rifampin

38
Q

Contraindications
Allergy to
Obstructive gallbladder disease
Current meningococcal disease

Precautions
History of liver disease
History of alcoholism
Concurrent use of other hepatotoxic drugs

A

rifampin

39
Q

Decreases blood levels of oral contraceptives, warfarin (Coumadin) and several HIV drugs (protease inhibitors)

A

rifampin

40
Q

Reduces length of treatment
Reduces bacterial resistance
Treatment divided into phases
Susceptibility testing should occur prior to medication administration

A

multi drug therapy for tb

41
Q

Peripheral neuropathy most common reaction to isoniazid- monitor carefully- give pyridoxine to prevent
Common reactions to rifampin- GI
Ethambutol- itching, joint pain, GI, malaise, tingling of extremities
Pyrazinamide-liver toxicity

A

adverse effects of anti tb drugs

42
Q

Sputum test for acid-fast bacilli will be negative 2 to 3 months after starting therapy
Symptoms dissipate
Client will not spread TB to others
Often use directly observed therapy (DOT)

A

goal of treatment for tb patients

43
Q

when taking ____ bodily fluids may be red or orange

A

rifampin

44
Q

divided doses of ____ may cause visual disturbances

A

ethambutol

45
Q

collect sputum specimens for acid fast bacilli when?

A

first thing in the morning

46
Q

clients takin INH and ethambutol should have frequent _____

A

eye exams

47
Q

Close contact
Immune compromise
Conversion
Children
Family members
Often lasts up to a year
Contraindicated for those with liver disease

A

prophylactic treatment

48
Q

TB can be spread to other parts of the body via the bloodstream

A

miliary tb