TB Pharm

Question 1

What is the acronym of drugs used to treat TB

Answer 1

RIPE plus streptomycin

Rifampin, Isoniazid, Pyrazinamide, Ethambutol

RIP 2 months, ER 4 months

Question 2

When to add second line treatment

Answer 2

drug resistance, contraindications, intolerance

Question 3

What to monitor

Answer 3

liver function tests, hep B/C

Question 4

Rifampin

Answer 4

TB and meningococcal carriers

don’t use if taking saquinavir or other -virs–> hepatocellular toxicity, loss of efficacy/viral resistance

liver dysfunction with fatalities

inducer of CYP, accelerate elimination

Question 5

Isoniazid

Answer 5

inhibits synthesis of mycoloic acid (cell wall)

bactericidal against mycobacterium tuberculosis

fatal hepatitis months after tmt

Nervous system and liver sx

interact with food, acetaminophen, carbamazepine, valproate, etc

Question 6

Pyrazinamide

Answer 6

contra: severe hepatic damage and acute gout

caution with DM

Question 7

Ethambutol

Answer 7

oral chemo

don’t use by itself

vision changes in young children and unconscious patients

optic neuritis

Question 8

Streptomycin

Answer 8

mod-severe inf of susceptible strains

limited therapy for non-TB infections

hypersensitivity to aminoglycosides

vestibular ototoxicity

neurotoxic reactions with impaired renal function or azotemia