TBL 5 Flashcards
Key inducer of Acute Phase Response (9) ?
key repressors of APR?
positive and negative acute phase proteins
what pathogens are opnonized by MBL ?
what is the role of the complement system proteins, C3a and C5a on certain cells? what cell types do they act on?
what is the sensor of the inflammasome ? what cytokine does it activate? what pathway does it activate?
how does caspase 1 become active?
clinical correlation with an overactive Caspase 1?
overactivation of caspase 1 leads to _______
effect of these mutations
what are the 4 morphological forms of acute inflammation?
ulcer
purulent or suppurative inflammation
serous inflammation
fibronous inflammation
during the vascular changes of acute infllamtion what are the vasodilators?
NO, histamine, prostaglandin
what factors induce vascular permeability which form ______.
histamine, leukotrienes TNF alpa, c3a c5a
what stimulated adhesion molecules?
what are the adhesion molecules
IL-1 and TNF-alpha
what are the steps in recruitment and chemotaxis of leukocytes ?
Leukocyte adhesion deficiency Type 1( LAD-1) vs type 2
how do these patients present?
what are the sterps following recruitment and chemotaxis of leukocytes during acute inflammation?
what is the underlying mechanism and what chemical trigger it?
jarisch-Herxheimer Reaction:
outcomes of acute inflammation
what are the steps of acute inflammation
