TCA Cycle and ETC Flashcards

1
Q

what is pyruvate turned into to enter TCA?

A

acetyl coa

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2
Q

what is enzyme that turns pyruvate into TCA?

A

pyruvate dehydrogenase

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3
Q

what does acetly coa join to make citrate in step one of TCA?

A

oxaloacetate

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4
Q

how many NADH does TCA make

A

3

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5
Q

how many FADH2 does TCA make

A

1

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6
Q

how many GTP does TCA make?

A

1

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7
Q

what is enzyme that makes citrate in TCA?

A

citrate synthase

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8
Q

what comes after citrate in TCA?i

A

isocitrate

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9
Q

what is isocitrate turned into in TCA?

A

a ketoglutorate

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10
Q

What is enzyme that turns isocitrate into a ketoglutarate?

A

isocitrate dehydrogenase

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11
Q

what comes out of TCA during isocitrate dehdrogenase rxn?

A

CO2 and NADH

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12
Q

what is a ketoglutarate turned into in TCA?

A

succinyl CoA

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13
Q

what is enzyme that turns a ketoglutarate into succinyl coa?

A

a ketoglutarate dehdryogenase

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14
Q

what comes off during a ketoglutarate dehydrogenase turning a keto into succinyl coa?

A

CO2 and NADH

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15
Q

what is succinyl coa turned into?

A

succinate

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16
Q

what is succinate turned into?

A

fumarate

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17
Q

what enzymes activates succinate into fumarate?

A

succinate dehydrogenase

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18
Q

what comes off during succinate dehydrogenase rxn?

A

FADH 2

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19
Q

what is fumarate made into?

A

malate

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20
Q

what is malate made into?

A

oxaloacetate

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21
Q

what is enzyme that makes malate inot oxaloacetate?

A

malate dehydrogenase

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22
Q

what comes off during malate dehdryogenase rxn?

A

NADH

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23
Q

what three things highly regulate pyruvate dehydrogenase?

A

ATP, NADH and acetyl CoA (all if high inhibit)

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24
Q

what are the two main rate limiting enzymes in the TCA cycle?

A

a ketoglutarate dehydrogenase and isocitrate dehydrogenase

25
how many complexes in ETC?
4
26
what is name of complex I in ETC?
NADH-Q oxireductase
27
what is name of complex II in ETC?
succinate Q reductase
28
complex I takes electrons from what molecule?
NADH
29
what does complex I give NADH electrons to?
ubiquinone
30
where does ubiquinone take NADH electrons from complex I
to complex III
31
what is name of complex III in ETC?
Q-cytochrome c oxireductase
32
what molecule does complex II take electrons from?
FADH2
33
where do electrons from complex II get passed to?
ubiquinone and to complex III
34
what takes electrons from complex III to IV?
cytochrome C
35
what happens at complex IV?
cytochrome C is oxidized and O2 turned into H20 via electrons
36
how manY h+ is pumped at complex I?
4
37
how manY h+ is pumped at complex II?
0
38
how manY h+ is pumped at complex III?
2
39
how manY h+ is pumped at complex IV?
4
40
what is another name for complex IV?
cytochrome C oxidase
41
what is complex V?
ATO synthase
42
what are the two divisions of ATP synthase?
Fo anf F1
43
where is Fo?
in inner membrane of mitochondria
44
where is F1?
in inner cytoplasm of mitochondria
45
what is the fxn of Fo of ATP synthase?
8-14 c subunits that are the proton channel
46
what subunit of F1 is in charge of producing and releasing the ATP?
Beta
47
what are the three states that beta subunit of F1 f ATP synthase can be in?
L O and T
48
what is the L state of the B subunit?
beta binds ADP and P
49
what is the T form of the B subunit?
ATP is made
50
what is the O form of the B subunit?
ATP is Off (released)
51
what subunit of F1 of ATP synthase is in charge of rotating B subunit through different states?
gamma subunit
52
what is total ATP from one glucose?
30
53
how many ATP from glycolysis?
net of 2
54
how many ATP from TCA cycle?
2 ATP
55
how many NADH made in glycolysis?
2 NADH
56
how many NADH in TCA cycle from 2 acetyl CoAs?
6 NADH
57
how many FADH2in TCA cycle from 2 acetyl CoAs?
2 FADH2
58
how many NADH from decarboxylation of pyruvate into acetyl coa?
2 NADH