TCAs Flashcards

1
Q

Tertiary amines

A

Amitriptyline
Clomipramine
Imipramine
Doxepin
Amoxapine

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2
Q

Secondary amines

A

Desipramine
Nortriptyline
Maprotiline

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3
Q

MOA of TCAs

A

Inhibits reuptake of both serotonin and NE which leads to increased concentration of these neurotransmitters in the synapticc elect

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4
Q

indications for TCAs

A

depression
insomnia
neuropathies
pain disorders
Insomnia and anxiety due to sedating effects

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5
Q

What TCA is approved for OCD

A

Clomipramine (if older than 10)

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6
Q

ADE of TCAs

A

Anticholinergic MC
sedation/drowsiness, increased appetite, weight gain, confusion (due to antihistamine effects)
Orthostatic hypotension, dizziness (due to alpha-1 adrenergic receptor blockade)
sexual dysfunction
prolonged QT interval

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7
Q

What is the best indicator for an overdose of TCA

A

prolonged QT interval

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8
Q

Overdose 3C’s for TCAs

A

Cardiotoxicity
Coma
Convulsions (lowers seizure threshold)

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9
Q

How do you treat cardio toxicity from TCAs

A

sodium bicarbonate

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10
Q

which TCAs are the most anticholinergic

A

Amitriptyline
Doxepin

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