Flashcards in Teratology Deck (17):
Most common fetal anomaly from cyclophosphamide?
Missing or hypoplastic digits
What are the fetal effects of ACE inhibitors?
No structural malformations from first trimester exposure have been noted.
Most commonly there is late-onset growth restriction and oligo followed by profound and prolonged neonatal hypotension and anuria.
The most severe consequence is renal tubular dysgenesis which causes early onset oligo, pulmonary hypoplasia and limb contractures.
Hypocalvaria is also strongly linked to ACE inhibitor exposure.
Which of the following medications are contraindicated in breastfeeding?
Cyclosporine, PTU - ok, Warfarin, Phenytoin
Anticonvulsants that should be avoided in pregnancy, at least in first trimester
Overall rate of major fetal malformations with phenobarbital
Overall rate of major fetal malformations with lamotrigine
Overall rate of major fetal malformations with carbamazepine
Fetal malformations associated with carbamazepine
CraniofacialFingernail hypoplasiaDevelopmental delayNeural tube defects
Overall rate of major fetal malformations with valproic acid
Fetal malformations associated with valproic acid
Neural tube defects (1-2%)Cleft lip/palateDevelopmental delayHypospadiasCardiac malformationsEndocrine disorders
Fetal malformations associated with phenytoin
Fetal hydantoin syndrome:Prenatal & postnatal growth deficiencyMicrocephalyDysmorphic faciesMental deficiencyCleft lip/palate
How common is fetal hydantoin syndrome
May be seen in 11% of infants exposed to phenytoin in utero, but 30% may have lesser degrees of impairment
Fetal malformations associated with topiramate
Oral cleftsIncreased risk of low birth weight
Fetal malformations associated with lamotrigine
Which is more teratogenic: valproic acid or carbamazepine?
Valproic acid + ___ is particularly teratogenic.