terms to know Flashcards
the amount of a drug that enters central circulation and is able to cause an effect
bioavailability
administration of medication in a single dose (as opposed to an infusion)
bolus
for calculation purposes, this is the total amount of medication as packaged (total amount of a drug in the syringe, ampule, etc)
concentration
the drug amount intended for administration
dose
delivery of medication through the GI tract (oral, sublingual, rectal)
enteral
period of time required for concentration of drug in the body to be reduced by one half
half life
the amount of an ingested substance (in mg/kg) that kills 50% of a test sample
LD (lethal dose) 50
delivery of a medication outside of the GI tract (IV, IO, IM, SQ, intranasal)
parenteral
movement of a drug through the body, includes absorption, bioavailability, distribution, metabolism, excretion)
pharmacokinetics
the mechanism of action of a medication
pharmacodynamics
the range between minimum effective dose of a medication and the maximum safe dose. The narrower the therapeutic index, the more risk associated with the medication
therapeutic index
for calculation purposes, this is the total amount of fluid available as packaged (total amount of fluid in the syringe, ampule, etc)
volume
related to the sympathetic nervous system
adrenergic
*think adrenaline
unintended effect of a medication administration
adverse effect
medication that stimulated a specific response
agonist
medication that reduces pain
analgesic
medication that inhibits a specific action
antagonist
single dose of a medication, given all at once
bolus
related to the parasympathetic nervous system
cholinergic
*think acetylcholine
circumstance when a medication should not be used
contraindication
repeated administration of a medication that produces effects that are more pronounced than the first dose
cumulative effect
categorization of medications with similarities or uses
drug class
tremors, slurred speech, restlessness, muscle twitching, anxiety side effects
extra pyramidal
diminishing of a physiological or emotional response to a frequently repeated stimulus
habituation
undesirable reactions produced by the normal immune system, including allergies and autoimmunity
hypersensitivity
solution that has a greater concentration of solutes on the outside of a cell when compared with the inside of a cell, causing fluid to move out of the cell
hypertonic solution
solution that has a lesser concentration of solutes on the outside of a cell when compared with the inside of a cell, causing fluid to move into the cell
hypotonic solution
circumstance when a medication should be considered
indication
sodium concentration same as intracellular fluid
isotonic solution
pharmacological effects of a medication
mechanism of action
interaction between two or more medications causing a response greater than the sum of of each individual medication
potentiation
resistant to treatment
refractory
any unwanted side effect of medication administration
side effect
desirable effects of medication administration
therapeutic effect
reduced response to a medication due to repeated use
tolerance
adverse or harmful side effects of medication administration
untoward effect
cellular processes that convert energy from nutrients into adenosine triphosphate (ATP), and then release waste products
cellular respiration
the passive part of breathing
exhalation
oxygen exchange between the lungs and circulatory system
external respiration
oxygen deficiency
hypoxia
the active part of breathing
inhalation
oxygen exchange between blood and the cells of the body
internal respiration
volume of gas inhaled or exhaled per minute
respiratory rate x tidal volume
minute ventilation
delivery of oxygen to the blood
oxygenation
the physical movement of moving air in and out of the lungs
ventilation
abdominal swelling
ascites
*consider liver disease, CHF, renal failure
bruising around the umbilicus
cullens sign
*consider intra-abdominal bleeding
a field conclusion of the patients problem based on the clinical presentation and the exclusion of other possible causes through considering the differential diagnosis
field impression
bruising over flank area
grey turners sign
*consider intra-abdominal bleeding
depression left by pressure of finger
pitting edema
*consider CHF or renal failure
measure or monitoring of exhaled CO2
capnography
area of necrosis or death
infarct
non-invasive measurement of oxygen saturation of hemoglobin
pulse oximetry SpO2
non-invasive measurement of carbon monoxide saturation of hemoglobin
pulse CO-oximetry SpCO
non-invasive measurement of methemoglobin
SpMet
swelling of the lower layer of skin and underlying tissue. Swelling may occur in the face, tongue, larynx, abdomen, arms and legs. Often associated with urticaria
angioedema
early shock where the body still maintains adequate perfusion
compensated shock
later shock where the body can no longer maintain adequate perfusion
decompensated shock
severe bleeding, leading to death
exsanguination
bleeding
hemorrhage
stage of shock leading to inevitable death
irreversible shock
MAP
mean arterial pressure
*DBP+1/3 (SBP-DBP)
progressive failure of at least two organ systems
multiple organ dysfunction syndrome
*MODS
hives
urticaria
resistance the left heart overcomes during contraction
afterload
a weakening in the wall of an artery
aneurysm
edema in the abdomen
ascites
enlargement of the heart, often due to hypertension
cardiac hypertrophy
volume of blood ejected by left ventricle in one minute
cardiac output
*stroke volume x heart rate
rate of cardiac contraction
chronotrope
speed of cardiac conduction velocity
dromotrope
an infection of the endocardium, usually involving the heart valves
endocarditis
percentage of blood ejected from a filled ventricle
ejection fraction
ventricles fail to respond to an impulse. On an ECG, the pacemaker spike will appear, but it will not be followed by a QRS complex
failure to capture
pacemaker malfunction that occurs when the pacemaker does not detect the patients myocardial depolarization. May be seen on an ECG tracing as a spike following a QRS complex too early
Failure to sense
force of cardiac contraction
inotrope
difficulty breathing while supine
orthopnea
acute onset of difficulty breathing at night, usually while sleeping
paroxysmal nocturnal dyspnea
inflammation of the pericardium
pericarditis
volume of fluid returning to the right heart
preload
variable angina caused by coronary artery spasms
prinzmetals angina
the more the heart is stretched (within limits), the greater the resulting force of contraction
starlings law
amount of blood ejected by the left ventricle during one contraction
stroke volume
non cardiogenic pulmonary edema
acute respiratory distress syndrome
*ARDS
right heart failure
cor pulmonale
coughing up blood
hemoptysis
uses an impedance valve to increase volume of air remaining in lungs at end of expiration to improve gas exchange
positive end-expiratory pressure
*PEEP
crackling under the skin upon palpation due to trapped air. Typically found in chest neck or face
subcutaneous emphysema
volume of air inhaled or exhaled with each breath
tidal volume
difficulty with coordinated movement
ataxia
arms and legs extended
posturing
decerebrate
arms flexed and legs extended
posturing
decorticate
*think drawing arms to core
difficulty swallowing
dysphagia
unilateral weakness
hemiparesis
unilateral paralysis
hemiplegia
involuntary eye movement
nystagmus
brain damage due to lack of vitamin B1
wernickes encephalopathy
deep rapid respirations
kussmaul respirations
excessive thirst
polydipsia
excessive hunger
polyphagia
excessive urination
polyuria
reactions that present like anaphylaxis but are not lgE-mediated
anaphylactoid reaction
life threatening allergic reaction.
unlike anaphylactoid reactions, this requires the patient to be sensitized, and mediated through lgE antibodies
anaphylaxis
immune cells produced by body to attack invading substances
antibodies
any substance that can produce an immune response
antigen
invading substance that can trigger an allergic or anaphylactic response
pathogen
immune response that occurs when an antigen comes into contact with the immune system for the first time
primary response
immune response that occurs after development of specific antibodies following primary response
secondary response
red, raised bumps across the body
hives/urticaria
inflammation of the coiled tube (epididymis) at the back of the testicle
epididymitis
blood in the stool
hematochezia