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Immunology and Serology > Test 1 > Flashcards

Flashcards in Test 1 Deck (37)
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0

What is the function of the immune system?

To recognize self from non-self and to defend the body from non-self.

1

What are the components of the first line of defense?

Unbroken skin, secretions such as mucus, sebum, lactic acid in sweat, ear wax, and stomach fluids. IgA, acidity and alkalinity, tears, cilia in lungs, and saliva.

2

What are the components of the 2nd line of defense?

*AKA natural immunity*
Composed of cellular and humoral defense.
Cellular - Mast cells, neutrophils, macrophages
Humoral - Lysozymes, intereferon, complement

3

What are the components of the 3rd line of defense?

*AKA adaptive immunity*
Allows the body to recognize, remember, and respond to a specific stimulus, an antigen.

4

What are the consequences of the immune system?

Allergies, rejected transplant organ, autoimmune disorder

5

What is Innate immunity?

Natural or inborn resistance to infection after microorganisms have penetrated first line of defense.

6

What is acquired immunity?

Augmentation of the body defense mechanisms in response to a specific stimulus, which can cause the elimination of microorganism and recovery from disease. This response usually leaves the host with a specific memory (acquired resistance) which enables the body to respond effectively if reinfection with the same microorganisms occurs. Organized around T and B lymphs.

7

What are the types of acquired immunity??

Cellular and Humoral

8

What is artificial passive immunity?

Infusion of serum or plasma. Provides immediate protection but only temporary.

9

What is artificial active immunity?

Vaccination, which may consist of living suspensions, killed cells, or viruses, and extracted bacterial products.

10

What is active immunity?

The form of immunity produced by the body in response to stimulation by a disease-causing organism.

11

What is immediate hypersensitivity?

Process of the release of potent chemical mediators from sensitized mast cells mediated by IgE.

12

What is cell-mediated immunity?

Moderated by a link between T lymphs and phagocytic cells. A immunity that has lymphs which helps with immunologic specificity.

13

What are five factors that are associated with immunologic disease?

Age
Nutrition
Proteins, carbs, and lipids
Vitamins and Minerals
Brain

14

What is the MHC?

Major histocompatability complex.
A genetic region in humans and other mammals responsible for signaling between lymphs and antigen bearing cells. Also a major determinant of transplant compatibility.

15

What are physical properties of an antigen?

Foreignness, degradability, molecular weight, stability, and complexity.

16

What is the function of an antigen?

Bind to and neutralize bacterial toxins or bind to the surfaced of bacteria, viruses, and parasites.

17

What is the molecular weight of IgG?

160,000

18

What is the molecular weight of IgA?

360,000

19

What is the molecular weight of IgM?

900,000

20

What is the molecular weight of IgE?

200,000

21

What is the molecular weight of IgD?

160,000

22

What is the concentration of IgM?

1.5 mg/mL

23

What is the concentration of IgG?

13.5 mg/mL

24

What is the concentration of IgA?

3.5 mg/mL

25

What is the concentration if IgE?

0.05 mg/mL

26

What is the concentration of IgD?

Trace

27

What is an isotype determinant?

Determines which class immunoglobulin is. Dominant type found in all animals of species.

28

What is the allotype determinants?

Small genetic differences within the same group. Variants found on some but not all of a species Ig molecule. Found mainly on constant heavy and constant light chains, sometimes variable heavy and light.

29

What is the idiotype determinant ?

The antigenic characteristics of the antibody variable region.