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Flashcards in Test 2 Deck (34)
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1

active vitamin C isomer

L isomer

2

Vitamin C role in collagen

3 hydroxylation reactions require Vitamin C.

3

Vitamin C primary role as antioxidant

-Reducing agent or electron donor and thereby has antioxidant activity or functions.
-Regenerates viatmin E and glutathione

4

What is the Body pool of vitamin C

2g

5

RDA of vitamin C

• Men 90 mg
• Women 75 mg

6

UI of Vitamin C

2g

7

Vitamin C deficiency

Scurvy
symptoms
- fatigue, enlarged hair follicles, red skin discoloration, ruptured blood vessels, easy bruising
- joint pain
- oral changes

8

functions of vitamin C

collagen synthesis, carnitine synthesis, tyrosine synthesis and catabolism and neurotransmitter synthesis

9

mineral interference with vitamin C

iron and copper

10

vitamin C absorption rates

• Absorption of vitamin decreases with increased intake
o 16% is absorbed at high intakes (~12g) vs 98% at low intakes (<20 mg)

11

Thaimin B?

B1

12

Riboflavin B?

B2

13

Niacin B?

B3

14

Pantothenic Acid B?

B5

15

Pyridoxine B?

B6

16

Biotin B?

B7

17

Folate B?

B9

18

Cobalamin B?

B12

19

thaimin Major function

• Metabolism of carbohydrates, branched chain amino acids and fatty acids – energy
o Energy transformation (coenzyme role)
o Synthesis of pentoses and NADPH: (coenzyme role)
o Membrane and nerve conduction (non coenzyme)

20

Riboflavin Major function

o Oxidation-reduction (redox) reactions
 metabolism of carbohydrates, lipids, and proteins.
 Glutathione reductase
o Metabolism of other vitamins
 Conversion of B6 to

21

Niacin Major function

-200 enzymes require NAD and NADP
-redox role
-NADPH, Acts as a reducing agent in many biosynthetic pathways such as fatty acid, cholesterol and steroid hormone synthesis

22

Pantothenic Acid Major function

• Component CoA and 4’phosphopantethenine
• Acetylates nutrients including sugars and proteins among others
• Metabolism of carbs, lipids and protein
• critical to the manufacture of red blood cells, as well as sex and stress-related

23

Pyridoxine Major function

-amino acid metabolism
-gene expression
-schiff base
-First step in synthesis of heme
-Niacin synthesis from tryptophan requires PLP

24

Biotin Major function

• help the body to convert food (carbohydrates) into fuel (glucose), which is used to produce energy.
• metabolize fats and protein.
• biotin required for cells to progress normally

25

Folate Major function

o One carbon metabolism
o Nucleic acid metabolism
 DNA metabolism
• Synthesis of DNA from precursors
• Synthesis of methionine from homocysteine
• SAM
o Amino acid metabolism

26

Cobalamin major functions

o conversion of homocysteine into methionine,
o converts L methylmalonyl-CoA to succinyl-CoA

27

Thiamin stored

• Human body contains about 30mg of thiamin,
o High but small concentrations in liver, skeletal muscles, heart, kidneys and brain
o Skeletal muscles are thought to contain half of body’s thiamin

28

Riboflavin stored

o greatest amount found in liver, kidneys and heart

29

Niacin stored

• NAD or NADP trapped in cell

30

Pantothenic Acid stored

• Pantothenic acid is free in blood, primarily within red blood cells
• Most Pantothenic acid is used to synthesize or resynthesize CoA, found in high concentrations in the liver, adrenal gland, kidney, brain and heart