Test 2: Blood Vessels & Lymphatic System FINAL Flashcards

Question

Continuous Capillaries

Answer 1

–Continuous capillaries: **Location:** occur in most tissues **Structure:** * Endothelial cells have tight junctions forming a continuous tube with intercellular clefts * Allow passage of solutes such as glucose * Pericytes wrap around the capillaries and contain the same contractile protein as muscle **Function:** –Contract and regulate blood flow

Answer 2

**Location:** kidneys, small intestine **Structure:** * Organs that require rapid absorption or filtration * Endothelial cells riddled with holes called filtration pores (fenestrations) –Spanned by very thin glycoprotein layer Allow passage of only small molecules **Function:** * Allow for rapid absorbtion/ filtation * Allow passage of only small molecules

Answer 3

–Sinusoids (discontinuous capillaries): **Location:** liver, bone marrow, spleen **Structure:** •Irregular blood-filled spaces with large fenestrations **Function:** •Allow proteins (albumin), clotting factors, and new blood cells to enter the circulation

Answer 4

•Capillary beds are networks of 10-100 capillaries –Usually supplied by a single arteriole or metarteriole –At distal end, capillaries transition to venules or drain into a throroughfare channel (continuation of metarteriole)

Answer 5

–At any given time, three-fourths of body’s capillaries are shut down * Most control of flow involves constriction of arterioles that are upstream from the capillaries * Within the capillary bed, precapillary shincters control flow –When sphincters are relaxed, capillaries are well perfused with blood –When sphincters contract, they constrict the entry to the capillary and blood bypasses the capillary

Answer 6

**Structure:** * Greater capacity for blood containment than arteries * Thinner walls, flaccid, less muscular and elastic tissue **Function:** * Collapse when empty, expand easily * Have steady blood flow * Merge to form larger veins * Subjected to relatively low blood pressure –Averages 10 mm Hg with little fluctuation

Answer 7

1. Post Capillary Venules- smallest veins 2. Muscular Venules- up to 1 mm in diameter 3. Medium Veins- up to 10 mm in diameter 4. Venuous Sinuses 5. Large Veins- \> 10 mm in diameter

Answer 8

–Smallest Veins **Structure/ Function:** –Even more porous than capillaries so also exchange fluid with surrounding tissues –Tunica interna with a few fibroblasts and no muscle fibers –Most leukocytes emigrate from the bloodstream through venule walls

Answer 9

**Structure/ Function:** -Up to 1 mm in diameter –One or 2 layers of smooth muscle in tunica media –Have a thin tunica externa

Answer 10

Structure/ Function: ## Footnote •up to 10 mm in diameter –Thin tunica media and thick tunica externa –Tunica interna forms venous valves –Varicose veins result in part from the failure of these valves –Skeletal muscle pump propels venous blood back toward the heart

Answer 11

–Veins with especially thin walls, large lumens, and no smooth muscle –Dural venous sinus and coronary sinus of the heart –Not capable of vasomotor responses

Answer 12

–Some smooth muscle in all three tunics –Thin tunica media with moderate amount of smooth muscle –Tunica externa is thickest layer •Contains longitudinal bundles of smooth muscle –Venae cavae, pulmonary veins, internal jugular veins, and renal veins

Answer 13

•Blood pools in the lower legs of people who stand for long periods stretching the veins –Cusps of the valves pull apart in enlarged superficial veins, further weakening vessels –Blood backflows and further distends the vessels, their walls grow weak and develop into varicose veins * Hereditary weakness, obesity, and pregnancy also promote problems * Hemorrhoids are varicose veins of the anal canal

Answer 14

•Simplest and most common route for blood – Heart \> arteries \> arterioles \> capillaries \> venules \> veins –Passes through only one network of capillaries from the time it leaves the heart until the time it returns

Answer 15

* The most important blood in the body is in the capillaries * Only through capillary walls are exchanges made between the blood and surrounding tissues * **Capillary exchange**—two-way movement of fluid across capillary walls –Water, oxygen, glucose, amino acids, lipids, minerals, antibodies, hormones, wastes, carbon dioxide, ammonia

Answer 16

–Blood flows through two consecutive capillary networks before returning to heart * Between hypothalamus and anterior pituitary * In kidneys * Between intestines to liver

Answer 17

•Chemicals pass through the capillary wall by three routes 1. Through endothelial cell cytoplasm 2. Intercellular clefts between endothelial cells 3. Filtration pores (fenestrations) of the fenestrated capillaries

Answer 18

convergence point between two vessels other than capillaries

Answer 19

–Diffusion, transcytosis, filtration, and reabsorption

Answer 20

(shunt) Artery flows directly into vein, bypassing capillaries

Answer 21

•Diffusion is the most important form of capillary exchange –Glucose and oxygen, being more concentrated in blood, diffuse out of the blood –Carbon dioxide and other waste, being more concentrated in tissue fluid, diffuse into the blood •Capillary diffusion can only occur if: –The solute can permeate the plasma membranes of the endothelial cell, or –Find passages large enough to pass through •Filtration pores and intracellular clefts

Answer 22

–Most common –One vein empties directly into another –Reason vein blockage is less serious than arterial blockage

Answer 23

1.Lipid-soluble substances –Steroid hormones, O\_2, and CO\_2 diffuse easily through plasma membranes 2.Water-soluble substances –Glucose and electrolytes must pass through filtration pores and intercellular clefts 3.Large particles such as proteins held back

Answer 24

–Two arteries merge –Provides collateral (alternative) routes of blood supply to a tissue –Coronary circulation and common around joints

Answer 25

* endothelial cells pick up material on one side of their membrane by pinocytosis or receptor-mediated endocytosis, transport vesicles across cell, and discharge material on other side by exocytosis * Important for fatty acids, albumin, and some hormones (insulin)

Answer 26

* Fluid filters out of the arterial end of the capillary and osmotically reenters at the venous end * Delivers materials to the cell and removes metabolic wastes * Opposing forces: –Blood hydrostatic pressure drives fluid out of capillary •High on arterial end of capillary, low on venous end –Colloid osmotic pressure (COP) draws fluid into capillary * Results from plasma proteins (albumin)—more in blood * Oncotic pressure = net COP (blood COP − tissue COP) * Hydrostatic pressure –Physical force exerted against a surface by a liquid * Blood pressure in vessels is hydrostatic pressure * Capillaries reabsorb about 85% of the fluid they filter * Other 15% is absorbed by the lymphatic system and returned to the blood

Answer 27

* Capillary filtration at arterial end * Capillary reabsorption at venous end * Variations –Location * Glomeruli—devoted to filtration * Alveolar capillary—devoted to absorption –Activity or trauma Increases filtration

Answer 28

1. Capillaries usually reabsorb most of the fluid they filter with certain exceptions ## Footnote –Kidney capillaries in glomeruli do not reabsorb –Alveolar capillaries in lung absorb completely to keep fluid out of air spaces 2. Capillary activity varies from moment to moment –Collapsed in resting tissue, reabsorption predominates since BP is low –Metabolically active tissue has increase in capillary flow and BP •Increase in muscular bulk by 25% due to accumulation of fluid

Answer 29

•accumulation of excess fluid in a tissue –Occurs when fluid filters into a tissue faster than it is absorbed

Answer 30

1.Increased capillary filtration •Kidney failure, histamine release, old age, poor venous return 2.Reduced capillary absorption •Hypoproteinemia, liver disease, dietary protein deficiency 3.Obstructed lymphatic drainage •Surgical removal of lymph nodes

Answer 31

•the flow of blood back to the heart; relies on: pressure gradient, gravity, skeletal muscle pump, thoracic pump, and cardiac suction

Answer 32

1.Tissue necrosis –Oxygen delivery and waste removal impaired 2.Pulmonary edema –Suffocation threat 3.Cerebral edema –Headaches, nausea, seizures, and coma 4.Severe edema or circulatory shock –Excess fluid in tissue spaces causes low blood volume and low blood pressure

Answer 33

**1**.Pressure gradient * Blood pressure is the most important force in venous return * 7 to 13 mm Hg venous pressure toward heart * Venules (12 to 18 mm Hg) to central venous pressure: point where the venae cavae enter the heart (~5 mm Hg) **2.**Gravity drains blood from head and neck **3.**Skeletal muscle pump in the limbs •Contracting muscle squeezes blood out of the compressed part of the vein **4.**Thoracic (respiratory) pump •Inhalation—thoracic cavity expands and thoracic pressure decreases, abdominal pressure increases, forcing blood upward –Central venous pressure fluctuates * 2 mm Hg—inhalation, 6 mm Hg—exhalation * Blood flows faster with inhalation **5**.Cardiac suction of expanding atrial space

Answer 34

* Variable blood flow depending on state of exertion * At rest –Arterioles constrict, most capillary beds shut down –Total flow about 1 L/min. •During exercise –Arterioles dilate in response to muscle metabolites such as lactate, CO\_2, and H^+ –Blood flow can increase 20-fold * Blood is diverted from digestive and urinary organs * Muscular contraction impedes flow –Isometric contraction causes fatigue faster than intermittent isotonic contractions

Answer 35

* Low pulmonary blood pressure * Flow slower, more time for gas exchange –Oncotic pressure overrides blood (hydrostatic) pressure * Pulmonary capillaries absorb fluid (almost no filtration) * Prevents fluid accumulation in alveolar walls and lumens * Unique response to hypoxia –Pulmonary arteries constrict in diseased area –Redirects flow to better ventilated region

Answer 36

•any state in which cardiac output is insufficient to meet the body’s metabolic needs

Answer 37

* Hypertension—most common cardiovascular disease affecting about 30% of Americans over 50 * “The silent killer” –Major cause of heart failure, stroke, and kidney failure •Damages heart by increasing afterload –Myocardium enlarges until overstretched and inefficient •Renal arterioles thicken in response to stress –Drop in renal BP leads to salt retention (aldosterone) and worsens the overall hypertension

Answer 38

1. Cardiogenic Shock 2. Low Venous Return Shock- 3 types: - Hypovolemic shock (most cemmon) - Obstructed venous return shock - Venous Pooling (vascular) shock) 3. Neurogenic Shock 4. Septic Shock 5. Anaphalatic Shock 6. Compensated Shock 7. Decompensated Shock

Answer 39

–Fluid continually filters from the blood capillaries into the tissue spaces * Blood capillaries reabsorb 85% * 15% (2 to 4 L/day) of the water and about half of the plasma proteins enter the lymphatic system and then are returned to the blood

Answer 40

–inadequate pumping of heart (MI)

Answer 41

–Excess filtered fluid picks up foreign cells and chemicals from the tissues * Passes through lymph nodes where immune cells stand guard against foreign matter * Activates a protective immune response

Answer 42

cardiac output is low because too little blood is returning to the heart

Answer 43

–Lacteals in small intestine absorb dietary lipids that are not absorbed by the blood capillaries

Answer 44

•most common –Loss of blood volume: trauma, burns, dehydration

Answer 45

* 1. Lymph: the recovered fluid * 2. Lymphatic vessels: Transport the lymph * 3. Lymphatic tissues: composed of aggregates of lymphocytes and macrophages that popoulate many organs in the body * 4. Lymphatic organs: defense cells are especaially concentrated in these organs. They are seperated from surrounding organs by connective tissue capsules

Answer 46

–Tumor or aneurysm compresses a vein

Answer 47

–Clear, colorless fluid, similar to plasma, but much less protein –Originates as extracellular fluid drawn into lymphatic capillaries –Chemical composition varies in different places (in intestines, after lymph nodes)

Answer 48

–Long periods of standing, sitting, or widespread vasodilation

Answer 49

-Also called terminal lymphatics –Penetrate nearly every tissue of the body •Absent from cartilage, cornea, bone, and bone marrow –Capillary wall is endothelial cells overlapping each other like roof shingles –Closed at one end –Cells tethered to surrounding tissue by protein filaments •Gaps between cells are large enough to allow bacteria and cells to enter lymphatic capillary –Endothelium creates valve-like flaps that open when interstitial fluid pressure is high, and close when it is low

Answer 50

•loss of vasomotor tone, vasodilation –Causes from emotional shock to brainstem injury

Answer 51

•Larger ones composed of three layers –Tunica interna: endothelium and valves –Tunica media: elastic fibers, smooth muscle –Tunica externa: thin outer layer * Converge into larger and larger vessels * Collecting vessels course through many lymph nodes

Answer 52

–Bacterial toxins trigger vasodilation and increased capillary permeability

Answer 53

* Jugular * Subclavian * Bronchomediastinal * Intercostal * Intestinal (unpaired) * Lumbar

Answer 54

–Severe immune reaction to antigen, histamine release, generalized vasodilation, increased capillary permeability

Answer 55

1. Right Lymphatic Duct: receives lymph from right arm, right side of head and thorax; empties into right subclavian vein 2. Thoracic Duct: –larger and longer, begins as a prominent sac in abdomen called the cisterna chyli; receives lymph from below diaphragm, left arm, left side of head, neck, and thorax; empties into left subclavian vein

Answer 56

1.Compensated shock –Several homeostatic mechanisms bring about spontaneous recovery •Example: If a person faints and falls to a horizontal position, gravity restores blood flow to the brain 2.Decompensated shock –When compensation fails –Life-threatening positive feedback loops occur –Condition gets worse causing damage to cardiac and brain tissue

Answer 57

* Lymph flows under forces similar to those that govern venous return, except no pump (heart) * Lymph flows at low pressure and slower speed than venous blood * Moved along by rhythmic contractions of lymphatic vessels –Stretching of vessels stimulates contraction

Answer 58

•Total blood flow to the brain fluctuates less than that of any other organ (700 mL/min.) –Seconds of deprivation causes loss of consciousness –Four to 5 minutes causes irreversible brain damage –Though total flow is constant, blood is shifted to active brain areas from moment to moment

Answer 59

collect from thoracic duct

Answer 60

•Brain regulates its own blood flow to match changes in BP and chemistry –Cerebral arteries dilate as systemic BP drops, constrict as BP rises –Main chemical stimulus: pH * CO\_2+ H\_2 O →H\_2 CO\_3® H^++〖(HCO\_3)〗^- * Hypercapnia—CO\_2 levels increase in brain, pH decreases, triggers vasodilation * Hypocapnia—raises pH, stimulates vasoconstriction –Occurs with hyperventilation, may lead to ischemia, dizziness, and sometimes syncope

Answer 61

* Flow aided by skeletal muscle pump * Arterial pulsation rhythmically squeezes lymphatic vessels * Thoracic pump aids flow from abdominal to thoracic cavity * Valves prevent backward flow * Rapidly flowing blood in subclavian veins, draws lymph into it * Exercise significantly increases lymphatic return

Answer 62

* Hypercapnia—CO\_2 levels increase in brain, pH decreases, triggers vasodilation * Hypocapnia—raises pH, stimulates vasoconstriction –Occurs with hyperventilation, may lead to ischemia, dizziness, and sometimes syncope

Answer 63

1. Natural killer (NK) cells 2. T lymphocytes (T cells) 3. B lymphocytes (B cells) 4. Macrophages 5. Dendritic Cells 6. Reticular Cells

Answer 64

•brief episodes of cerebral ischemia –Caused by spasms of diseased cerebral arteries –Dizziness, loss of vision, weakness, paralysis, headache, or aphasia –Lasts from a moment to a few hours Often early warning of impending stroke

Answer 65

–Large lymphocytes that attack and destroy bacteria, transplanted tissue, host cells infected with viruses or that have turned cancerous

Answer 66

–Sudden death of brain tissue caused by ischemia •Atherosclerosis, thrombosis, ruptured aneurysm –Effects range from unnoticeable to fatal •Blindness, paralysis, loss of sensation, loss of speech common –Recovery depends on surrounding neurons, collateral circulation

Answer 67

Mature in thymus

Answer 68

-Mature/ Develop in the bone marrow –Activation causes proliferation and differentiation into plasma cells that produce antibodies

Answer 69

–Large, avidly phagocytic cells of connective tissue –Develop from monocytes –Phagocytize tissue debris, dead neutrophils, bacteria, and other foreign matter –Process foreign matter and display antigenic fragments to certain T cells alerting immune system to the presence of the enemy –Antigen-presenting cells (APCs)

Answer 70

–Branched, mobile APCs found in epidermis, mucous membranes, and lymphatic organs –Alert immune system to pathogens that have breached the body surface

Answer 71

1.Primary: –Obesity, sedentary behavior, diet, nicotine –90% of cases 2.Secondary: –Kidney disease, atherosclerosis, hyperthyroidism, Cushing syndrome –10% of cases

Answer 72

–Branched stationary cells that contribute to the stroma of a lymphatic organ

Answer 73

1. Lymphatic (Lymphoid) Tissue 2. Diffuse Lymphatic Tissue 3. Lymphatic Nodules (follicles))

Answer 74

•aggregations of lymphocytes in the connective tissues of mucous membranes and various organs

Answer 75

•simplest form –Lymphocytes are scattered (not clustered) –Prevalent in body passages open to the exterior * Respiratory, digestive, urinary, and reproductive tracts * Mucosa-associated lymphatic tissue (MALT)

Answer 76

–Dense masses of lymphocytes and macrophages that congregate in response to pathogens –Constant feature of the lymph nodes, tonsils, and appendix –Aggregated lymphoid nodules: dense clusters in the ileum, the distal portion of the small intestine

Answer 77

•Lymphatic organs are anatomically well-defined –Have connective tissue capsule that separates lymphatic tissue from neighboring tissues **Primary:** –Red bone marrow and thymus –Site where T and B cells become immunocompetent: able to recognize and respond to antigens **Secondary:** –Lymph nodes, tonsils, and spleen –Immunocompetent cells populate these tissues

Answer 78

•Red bone marrow is involved in hemopoiesis (blood formation) and immunity –Soft, loosely organized, highly vascular material –Separated from osseous tissue by endosteum of bone –As blood cells mature, they push their way through the reticular and endothelial cells to enter the sinus and flow away in the bloodstream

Answer 79

•Thymus—member of the endocrine, lymphatic, and immune systems –Houses developing lymphocytes –Secretes hormones regulating their activity –Bilobed organ located in superior mediastinum between sternum and aortic arch –Degeneration (involution) with age •Fibrous capsule gives off trabeculae (septa) that divide the gland into several lobes –Lobes have cortex and medulla populated by T lymphocytes •Epithelial cells seal off cortex from medulla forming blood–thymus barrier –Produce signaling molecules thymosin, thymopoietin, thymulin, interleukins, and interferon

Answer 80

•Lymph nodes—most numerous lymphatic organs –About 450 in typical young adult –Serve two functions * Cleanse the lymph * Act as a site of T and B cell activation * Elongated, bean-shaped structure with hilum * Enclosed with fibrous capsule with trabeculae that divide interior into compartments –Stroma of reticular fibers and reticular cells •Parenchyma divided into cortex and medulla –Germinal centers where B cells multiply and differentiate into plasma cells * Several afferent lymphatic vessels lead into the node along its convex surface * Lymph leaves the node through one to three efferent lymphatic vessels that leave the hilum

Answer 81

1. Cervical Lymph Node 2. Axillary Lymph Node 3. Thoracic Lymph Node 4. Abdominal Lymph Node 5. Intestinal/ Mesentric Lymph Node 6. Inguinal Lymph Nodes 7. Popiteal Lymph Nodes

Answer 82

Structure/ Location: Deep and superficial group in the neck Function: Monitor lymph coming from head and neck

Answer 83

When a lymph node is under challenge by an antigen.. –Lymphadenitis: swollen, painful node responding to foreign antigen –Lymphadenopathy: collective term for all lymph node diseases

Answer 84

Structure/ Location: Concentrated in armpit Function: Recieve lymph from upper limb and female breast

Answer 85

•Metastasis—cancerous cells break free from original tumor, travel to other sites in the body, and establish new tumors –Metastasizing cells easily enter lymphatic vessels –Tend to lodge in the first lymph node they encounter –Multiply there and eventually destroy the node •Swollen, firm, and usually painless –Tend to spread to the next node downstream –Treatment of breast cancer is lumpectomy, mastectomy, along with removal of nearby axillary nodes

Answer 86

Structure/ Location: –In thoracic cavity, especially embedded in mediastinum Function:–Receive lymph from mediastinum, lungs, and airway

Answer 87

•patches of lymphatic tissue located at the entrance to the pharynx –Guard against ingested or inhaled pathogens –Covered with epithelium –Have deep pits: tonsillar crypts lined with lymphatic nodules –Tonsillitis and tonsillectomy

Answer 88

Structure/ Location: –Occur in posterior abdominopelvic wall Function: –Monitor lymph from the urinary and reproductive systems

Answer 89

–Palatine tonsils * Pair at posterior margin of oral cavity * Most often infected –Lingual tonsils •Pair at root of tongue –Pharyngeal tonsil (adenoids) •Single tonsil on wall of nasopharynx

Answer 90

Structure/ Location: –Found in the mesenteries, adjacent to the appendix and intestines Function: –Monitor lymph from the digestive tract

Answer 91

* Spleen—the body’s largest lymphatic organ * Parenchyma exhibits two types of tissue –Red pulp: sinuses filled with erythrocytes –White pulp: lymphocytes, macrophages surrounding small branches of splenic artery •Spleen is highly vascular and vulnerable to trauma and infection –Ruptured spleen requires splenectomy, but this leaves person susceptible to future infections, premature death Function: –Healthy red blood cells (RBCs) come and go –For old, fragile RBCs, spleen is “erythrocyte graveyard” –Blood cell production in fetus (and very anemic adults) –White pulp monitors blood for foreign antigens and keeps an army of monocytes for release when needed –Stabilizes blood volume through plasma transfers to lymphatic system

Answer 92

Strucure/ Location/ Function: –In the groin and receive lymph from the entire lower limb

Answer 93

•agents capable of producing disease –Include viruses, bacteria, and fungi

Answer 94

Structure/ Location: –Occur on the back of the knee Function: –Receive lymph from the leg proper

Answer 95

–First line of defense: skin and mucous membranes –Second line of defense: several innate defense mechanisms •Leukocytes and macrophages, antimicrobial proteins, natural killer cells, inflammation, and fever –Third line of defense: adaptive immunity •Defeats a pathogen, and leaves the body with a “memory” of it so it can defeat it faster in the future

Answer 96

•guard equally against a broad range of pathogens –They lack capacity to remember pathogens –Local, nonspecific, lacks memory

Answer 97

–Three kinds of innate defenses: * Protective proteins * Protective cells * Protective processes

Answer 98

•body must develop separate immunity to each pathogen –Body adapts to a pathogen and wards it off more easily upon future exposure (memory)

Answer 99

1. Skin 2. Mucous Membranes 3. Subepitheial Areolar Tissue

Answer 100

–Makes it mechanically difficult for microorganisms to enter the body –Toughness of keratin –Too dry and nutrient-poor for microbial growth –Acid mantle: thin film of lactic and fatty acids from sweat and sebum that inhibits bacterial growth –Dermicidin, defensins, and cathelicidins: peptides in the skin that kill microbes

Answer 101

–Viscous barrier of hyaluronic acid •Hyaluronidase—enzyme used by pathogens to make hyaluronic acid less viscous

Answer 102

–Digestive, respiratory, urinary, and reproductive tracts are open to the exterior and protected by mucous membranes –Mucus physically traps microbes –Lysozyme: enzyme destroys bacterial cell walls

Answer 103

1. Neutrophils- wander in connective tissue killing bacteria using phagocytosis and digestion- does this through bacterialcidal chemicals like lysosome. 2. Eosinophils- found in mucous membrane and guard against parasites, allergens- promote action of basophils and mast cells. Phagocitize antigen antibody complexes and limits action onf histamine and other inflammatory complexes. 3. Basophils - Secrete chemicals that aid mobility and action of other leukocytes –Leukotrienes: activate and attract neutrophils and eosinophils –Histamine: a vasodilator, which increases blood flow •Speeds delivery of leukocytes to the area –Heparin: inhibits clot formation * Clots would impede leukocyte mobility * Mast cells also secrete these substances –Type of connective tissue cell very similar to basophils 4.Monocytes: * Monocytes—emigrate from the blood into connective tissues and transform into macrophages * Macrophage system—all the body’s avidly phagocytic cells, except leukocytes –Wandering macrophages: actively seek pathogens •Widely distributed in loose connective tissue 5.Lymphocytes: •Lymphocytes –Three basic categories: T, B, and NK cells –Many diverse functions •NK cells are part of innate immunity, all others are part of adaptive immunity; helper T cells function in both

Answer 104

cells that engulf foreign matter

Answer 105

–Wander in connective tissue killing bacteria –Can kill using phagocytosis and digestion –Can kill by producing a cloud of bactericidal chemicals * Lysosomes degranulate—discharge enzymes into tissue fluid causing a respiratory burst * Creates a killing zone around neutrophil, destroying several bacteria

Answer 106

T- 80% B-15% NK cells- 5%

Answer 107

–Found especially in mucous membranes –Guard against parasites, allergens (allergy-causing agents), and other pathogens –Kill tapeworms and roundworms by producing superoxide, hydrogen peroxide, and toxic proteins –Promote action of basophils and mast cells –Phagocytize antigen–antibody complexes –Limit action of histamine and other inflammatory chemicals

Answer 108

–Secrete chemicals that aid mobility and action of other leukocytes –Leukotrienes: activate and attract neutrophils and eosinophils –Histamine: a vasodilator, which increases blood flow •Speeds delivery of leukocytes to the area –Heparin: inhibits clot formation * Clots would impede leukocyte mobility * Mast cells also secrete these substances –Type of connective tissue cell very similar to basophils

Answer 109

NK Cells and T-Helper Cells

Answer 110

T (and T Helper) and B Cells

Answer 111

emigrate from the blood into connective tissues and transform into macrophages

Answer 112

•all the body’s avidly phagocytic cells, except leukocytes –Wandering macrophages: actively seek pathogens •Widely distributed in loose connective tissue –Fixed macrophages: phagocytize only pathogens that come to them * Microglia—in central nervous system * Alveolar macrophages—in lungs * Hepatic macrophages—in liver

Answer 113

* Proteins that inhibit microbial reproduction and provide short-term, Innate Immunity to pathogenic bacteria and viruses * Two families of antimicrobial proteins –Interferons –Complement system

Answer 114

•Interferons—secreted by certain cells infected by viruses –Of no benefit to the cell that secretes them –Alert neighboring cells and protect them from becoming infected –Bind to surface receptors on neighboring cells •Activate second-messenger systems within –The alerted cell synthesizes various proteins that defend it from infection •Breaks down viral genes or prevents replication –Also activates NK cells and macrophages •Destroy infected cell before they can liberate a swarm of newly replicated viruses –Activated NK cells destroy malignant cells

Answer 115

•a group of 30 or more globular proteins that make powerful contributions to both innate immunity and adaptive immunity –Synthesized mainly by liver –Circulate in the blood in inactive form –Activated by presence of a pathogen

Answer 116

–Activated complement brings about four methods of pathogen destruction * Inflammation * Immune clearance * Phagocytosis * Cytolysis –Three routes of complement activation * Classical pathway * Alternative pathway * Lectin pathway

Answer 117

–Requires antibody molecule •Thus part of adaptive immunity –Antibody binds to antigen on surface of the pathogenic organism •Forms antigen–antibody (Ag–Ab) complex –Changes the antibody’s shape * Exposing a pair of complement-binding sites * Binding of the first complement (C1) sets off a reaction cascade called complement fixation –Results in a chain of complement proteins attaching to the antibody

Answer 118

–Nonspecific, does not require antibody –C3 breaks down in the blood to C3a and C3b * C3b binds directly to targets such as human tumor cells, viruses, bacteria, and yeasts * Triggers cascade reaction with autocatalytic effect where more C3 is formed

Answer 119

–Lectins: plasma proteins that bind to carbohydrates * Bind to certain sugars of a microbial cell surface * Sets off another cascade of C3 production

Answer 120

* C3a stimulates mast cells and basophils to secrete histamine and other inflammatory chemicals * Activates and attracts neutrophils and macrophages * Speeds pathogen destruction in inflammation

Answer 121

* C3b binds with antigen–antibody (Ag-Ab) complexes to red blood cells * These RBCs circulate through liver and spleen * Macrophages of those organs strip off and destroy the Ag–Ab complexes leaving RBCs unharmed * Principal means of clearing foreign antigens from the bloodstream

Answer 122

* Neutrophils and macrophages cannot phagocytize “naked” bacteria, viruses, or other pathogens * C3b assists them by opsonization –Coats microbial cells and serves as binding sites for phagocyte attachment –Makes the foreign cell more appetizing

Answer 123

* C3b splits complement protein C5 into C5a and C5b * C5b binds to enemy cell * Attracts more complement proteins—membrane attack complex forms –Forms a hole in the target cell –Electrolytes leak out, water flows in rapidly, cell ruptures

Answer 124

* Natural killer (NK) cells continually patrol body looking for pathogens and diseased host cells * NK cells attack and destroy bacteria, transplanted cells, cells infected with viruses, and cancer cells * Recognize enemy cell and bind to it * Release proteins called perforins –Polymerize a ring and create a hole in its plasma membrane •Secrete a group of protein-degrading enzymes—granzymes –Enter through pore and degrade cellular enzymes and induce apoptosis (programmed cell death)

Answer 125

•an abnormal elevation of body temperature –Synonym: pyrexia; febrile—pertaining to fever –Results from trauma, infections, drug reactions, brain tumors, and other causes

Answer 126

•Fever is an adaptive defense mechanism that, in moderation, does more good than harm –Promotes interferon activity –Elevates metabolic rate and accelerates tissue repair –Inhibits reproduction of bacteria and viruses

Answer 127

•fever-reducing medications –Include aspirin and ibuprofen that inhibit Prostaglandin E\_2 synthesis

Answer 128

•Fever usually triggered by exogenous pyrogens—fever-producing agents –Glycolipids on bacterial and viral surfaces

Answer 129

•Endogenous pyrogens include polypeptides secreted by neutrophils and macrophages –These raise hypothalamic set point for body temperature –Neurons in the anterior hypothalamus secrete prostaglandin E\_2 which also raises set point

Answer 130

1. Onset 2. stadium, 3. defervescence

Answer 131

•local defensive response to tissue injury, including trauma and infection

Answer 132

–Limits spread of pathogens, then destroys them –Removes debris from damaged tissue –Initiates tissue repair

Answer 133

–Redness, swelling, heat, pain

Answer 134

•Suffix -itis denotes inflammation of specific organs: arthritis, pancreatitis, dermatitis

Answer 135

•small proteins that regulate inflammation and immunity –Secreted mainly by leukocytes –Alter physiology of receiving cell –Act at short range, neighboring cells (paracrines) or the same cell that secretes them (autocrines) –Include interferon, interleukins, tumor necrosis factor, chemotactic factors, and others

Answer 136

–Mobilization of body defenses –Containment and destruction of pathogens –Tissue cleanup and repair

Answer 137

* Most immediate requirement after tissue injury is to get defensive leukocytes to the site quickly * Achieved by local hyperemia—increasing blood flow –Local vasodilation due to vasoactive chemicals * Histamine, leukotrienes, and other cytokines * Secreted by basophils, mast cells, cells damaged by trauma, toxins, or organisms triggering inflammation * Hyperemia also washes toxins and metabolic waste from the site more rapidly * Vasoactive chemicals also stimulate endothelial cells to contract, thereby widening gaps between them –This increases capillary permeability –Fluid, leukocytes, and plasma proteins leave bloodstream * Including complement, antibodies, and clotting proteins * Selectins: cell-adhesion molecules made by endothelial cells that aid in the recruitment of leukocytes –Make membranes sticky, so leukocytes adhere to vessel wall (margination) –Diapedesis or emigration: leukocytes crawl through gaps in the endothelial cells and enter tissue fluid •Extravasated: cells and chemicals that have left the bloodstream

Answer 138

•Basis for the four cardinal signs of inflammation –Heat: results from hyperemia –Redness: due to hyperemia, and extravasated RBCs in the tissue –Swelling (edema): due to increased fluid filtration from the capillaries –Pain: from direct injury to the nerves, pressure on the nerves from edema, stimulation of pain receptors by prostaglandins, bacterial toxins, and bradykinin

Answer 139

–Margination •Selectins cause leukocytes to adhere to blood vessel walls –Diapedesis (emigration) •Leukocytes squeeze between endothelial cells into tissue space

Answer 140

•Priority of inflammation is to prevent pathogens from spreading throughout body –Fibrinogen that filters into tissue fluid clots •Forms a sticky mesh that walls off microbes –Heparin prevents clotting at site of injury * Pathogens are in a fluid pocket surrounded by clot * Attacked by antibodies, phagocytes, and other defenses * Neutrophils, the chief enemy of bacteria, accumulate at the injury site within an hour –After leaving the bloodstream, they exhibit chemotaxis

Answer 141

•Chemotaxis—attraction to chemicals such as bradykinin and leukotrienes that guide them to the injury site "'-Taxis"- movement

Answer 142

•Neutrophils quickly respond to and kill bacteria –Phagocytosis –Respiratory burst –Secrete cytokines for recruitment of macrophages and additional neutrophils –Macrophages and T cells secrete colony-stimulating factor to stimulate leukopoiesis (production of more leukocytes) thereby raising WBC counts in blood * Neutrophilia—5,000 cells/μL to 25,000 cells/μL in bacterial infection * Eosinophilia—elevated eosinophil count in allergy or parasitic infection

Answer 143

•Monocytes—the primary agents of tissue cleanup and repair –Arrive in 8 to 12 hours and become macrophages –Engulf and destroy bacteria, damaged host cells, and dead and dying neutrophils

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•Edema contributes to tissue cleanup –Swelling compresses veins and reduces venous drainage –Forces open valves of lymphatic capillaries, promoting lymphatic drainage –Lymphatics collect and remove bacteria, dead cells, proteins, and tissue debris better than blood capillaries

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•Pus—yellow accumulation of dead neutrophils, bacteria, cellular debris, and tissue fluid –Abscess: accumulation of pus in a tissue cavity

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•Platelet-derived growth factor is secreted by blood platelets and endothelial cells in injured area –Stimulates fibroblasts to multiply –Synthesizes collagen

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•Hyperemia delivers oxygen, amino acids, and other necessities for protein synthesis

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* Increased heat increases metabolic rate, speeds mitosis, and tissue repair * Fibrin clot forms a scaffold for tissue reconstruction * Pain makes us limit the use of a body part so it has a chance to rest and heal

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•a large population of widely distributed cells that recognize foreign substances and act to neutralize or destroy them

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–Systemic effect: throughout the body –Specificity: immunity directed against a particular pathogen –Memory: when reexposed to the same pathogen, the body reacts so quickly that there is no noticeable illness

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1. Cellular 2. Humoral

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* Lymphocytes directly attack and destroy foreign cells or diseased host cells * Rids the body of pathogens that reside inside human cells, where they are inaccessible to antibodies * Kills cells that harbor them

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* Mediated by antibodies that do not directly destroy a pathogen but tag it for destruction * Many antibodies are dissolved in body fluids (“humors”) * Can only work against the extracellular stages of infections by microorganisms

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•Natural active immunity –Production of one’s own antibodies or T cells as a result of infection or natural exposure to antigen •Artificial active immunity –Production of one’s own antibodies or T cells as a result of vaccination against disease –Vaccine: consists of dead or attenuated (weakened) pathogens that stimulate the immune response without causing the disease –Booster shots: periodic immunizations to stimulate immune memory to maintain a high level of protection

Answer 155

•Natural passive immunity –Temporary immunity that results from antibodies produced by another person * Fetus acquires antibodies from mother through placenta, milk * Artificial passive immunity –Temporary immunity that results from the injection of immune serum (antibodies) from another person or animal •Treatment for snakebite, botulism, rabies, tetanus, and other diseases

Answer 156

•any molecule that triggers an immune response –Large molecular weights of over 10,000 amu –Complex molecules with structures unique to the individual –Proteins, polysaccharides, glycoproteins, glycolipids –Characteristics enable body to distinguish “self” molecules from foreign ones

Answer 157

-Also known as Antigenic Determinants certain regions of an antigen molecule that stimulate immune responses

Answer 158

•too small to be antigenic in themselves –Can trigger an immune response by combining with a host macromolecule and creating a complex that the body recognizes as foreign –Subsequently, haptens alone may trigger response –Cosmetics, detergents, industrial chemicals, poison ivy, and animal dander –Penicillin binds to host proteins in allergic individuals

Answer 159

Immunoglobulin (Ig)

Answer 160

found in blood plasma, tissue fluids, body secretions, and some leukocyte membranes

Answer 161

A= Disulfide Bridges B=Antigen Binding Sites: Antigen-binding site: formed from the V regions of the heavy and light chain on each arm •Attaches to the epitope of an antigen molecule C=Light Chain= –Two light chains about half as long D=Hinge Region E=Heavy Chain F=Constant Regions= has the same amino acid sequence within one person and determines mechanism of antibody action G= Variable Regions= Variable (V) region in all four chains •Gives the antibody its uniqueness

Answer 162

Named for their structure of the C region 1. IGgA 2. IgD 3. IgE 4. IgG 5. IgM

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–monomer in plasma; dimer in mucus, saliva, tears, milk, and intestinal secretions * Prevents pathogen adherence to epithelia and penetrating underlying tissues * Provides passive immunity to newborns

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–monomer; B cell transmembrane antigen receptor •Thought to function in B cell activation by antigens

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–: monomer; transmembrane protein on basophils and mast cells •Stimulates release of histamine and other chemical mediators of inflammation and allergy –Attracts eosinophils to parasitic infections –Produces immediate hypersensitivity reactions

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–monomer; constitutes 80% of circulating antibodies •Crosses placenta to fetus, secreted in secondary immune response, complement fixation

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–pentamer in plasma and lymph •Secreted in primary immune response, agglutination, complement fixation

Answer 168

* Human immune system capable of as many as 1 trillion different antibodies * But there are as few as 20,000 genes in the human genome, so the variety of proteins must be accomplished by: –Somatic recombination •DNA segments shuffled and form new combinations of base sequences to produce antibody genes –Somatic hypermutation •B cells in lymph nodules rapidly mutate creating new sequences

Answer 169

–Natural killer (NK) cells: immune surveillance –T lymphocytes (T cells) –B lymphocytes (B cells)

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•Major cells of the immune system –Lymphocytes –Macrophages –Dendritic cells

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•Especially concentrated in strategic places such as lymphatic organs, skin, and mucous membranes

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–Born in bone barrow –Educated in thymus –Deployed to carry out immune function

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–Cortical epithelial cells release chemicals that stimulate maturing T cells to develop surface antigen receptors –With receptors, the T cells are now immunocompetent: capable of recognizing antigens presented to them –Positive selection –Medullary epithelial cells test T cells by presenting self-antigens to them; T cells can fail by: * Being reacting to the epithelial cell * Reacting to the self-antigen –Would attack one’s own tissues –T cells that fail are eliminated by negative selection * Clonal deletion—self-reactive T cells die and macrophages phagocytize them * Anergy—self-reactive T cells remain alive but unresponsive

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–eliminated by negative selection * Clonal deletion—self-reactive T cells die and macrophages phagocytize them * Anergy—self-reactive T cells remain alive but unresponsive

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•Negative selection leaves the body in a state of self-tolerance—the surviving T cells respond only to suspicious antigens (ignoring the body’s own proteins) –Only 2% of T cells pass the test

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•immunocompetent T cells that have not yet encountered foreign antigens

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–Naive T cells leave thymus and colonize lymphatic tissues and organs everywhere in the body

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•B cells develop in bone –Some fetal stem cells remain in bone marrow and differentiate into B cells * B cells that react to self-antigens undergo either anergy or clonal deletion, same as T cell selection * Self-tolerant B cells synthesize antigen surface receptors, divide rapidly, produce immunocompetent clones * Leave bone marrow and colonize same lymphatic tissues and organs as T cells

Answer 179

•T cells cannot recognize antigens on their own. Antigen-presenting cells (APCs) are required –Dendritic cells, macrophages, reticular cells, and B cells function as APCs •Function of APCs depends on major histocompatibility (MHC) complex proteins –Act as cell “identification tags” that label every cell of your body as belonging to you –Structurally unique for each individual, except for identical twins

Answer 180

Antigen Presenting Cells

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–APC encounters antigen –Internalizes it by endocytosis –Digests it into molecular fragments –Displays relevant fragments (epitopes) in the grooves of the MHC protein

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–Wandering T cells inspect APCs for displayed antigens –If APC only displays a self-antigen, the T cell disregards it –If APC displays a nonself-antigen, the T cell initiates an immune attack –APCs alert the immune system to presence of foreign antigen –Key to successful defense is to quickly mobilize immune cells against the antigen –With so many cell types involved in immunity, they require chemical messengers to coordinate their activities—interleukins

Answer 183

–A form of specific defense in which the T lymphocytes directly attack and destroy diseased or foreign cells –The immune system remembers the antigens and prevents them from causing disease in the future –Uses 4 classes of T-cells: cytotoxic, helper, regulatory, and memory

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1. cytotoxic 2. helper 3. regulatory 4. memory

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•killer T cells (T8, CD8, or CD8+) –“Effectors” of cellular immunity; carry out attack on enemy cells

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–Help promote T\_C cell and B cell action and innate immunity

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–Inhibit multiplication and cytokine secretion by other T cells; limit immune response –Like T\_H cells, T\_R cells can be called T4, CD4, CD4+

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–Descend from the cytotoxic T cells –Responsible for memory in cellular immunity

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–Recognition –Attack –Memory or the 3 Rs –Recognize –React –Remember

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* Aspects of recognition in cellular immunity: antigen presentation and T cell activation * Antigen presentation –APC encounters and processes an antigen –Migrates to nearest lymph node –Displays it to the T cells –When T cells encounter a displayed antigen on the MHC protein, they initiate the immune response •T cells respond to two classes of MHC proteins: MHC-1 and MHC-II –MHC-I proteins * Constantly produced by nucleated cells, transported to, and inserted on plasma membrane * If they are normal self-antigens, they do not elicit a T cell response * If they are viral proteins or abnormal cancer antigens, they do elicit a T cell response –Infected or malignant cells are then destroyed before they can do further harm to the body –MHC-II proteins (human leukocyte antigens, HLAs) * Occur only on APCs and display only foreign antigens * T\_C cells respond only to MHC-I proteins T\_H cells respond only to MHC-II proteins

Answer 191

–Begins when T\_C or T\_H cell binds to a MHC protein displaying an epitope that the T cell is programmed to recognize –T cell must then bind to another APC protein related to the interleukins –T cell must check twice to see if it is really bound to a foreign antigen—costimulation * Helps ensure the immune system does not launch an attack in the absence of an enemy * Would turn against one’s own body and injure our tissues * Successful costimulation will trigger clonal selection –Activated T cell undergoes repeated mitosis –Gives rise to a clone of identical T cells programmed against the same epitope –Some cells of the clone become effector cells and carry out the attack Other cells become memory T cells

Answer 192

* Helper and cytotoxic T cells play different roles in the attack phase of cellular immunity * Helper T cells play central role in coordinating both cellular and humoral immunity * When helper T cell recognizes the Ag-MHC Protein complex: –Secretes interleukins that exert three effects * Attract neutrophils and NK cells * Attract macrophages, stimulate their phagocytic activity, and inhibit them from leaving the area Stimulate T and B cell mitosis and maturation

Answer 193

* Cytotoxic T (T\_C) cells are the only T cells that directly attack other cells * When T\_C cell recognizes a complex of antigen and MHC-I protein on a diseased or foreign cell, it “docks” on that cell

Answer 194

–Perforin and granzymes—kill cells in the same manner as NK cells –Interferons—inhibit viral replication •Recruit and activate macrophages –Tumor necrosis factor (TNF)—aids in macrophage activation and kills cancer cells •After releasing chemicals, T\_C cell goes off in search of another enemy cell while chemical do their work

Answer 195

* Immune memory follows primary response in cellular immunity * Following clonal selection, some T\_C and T\_H cells become memory cells –Long-lived –More numerous than naive T cells –Fewer steps to be activated, so they respond more rapidly

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–Upon re-exposure to same pathogen later in life, memory cells launch a quick attack so that no noticeable illness occurs –The person is immune to the disease

Answer 197

* Humoral immunity is a more indirect method of defense than cellular immunity * B lymphocytes of humoral immunity produce antibodies that bind to antigens and tag them for destruction by other means –Cellular immunity attacks the enemy cells directly

Answer 198

•Works in three stages like cellular immunity –Recognition –Attack –Memory

Answer 199

–Immunocompetent B cell has thousands of surface receptors for one antigen –Activation begins when an antigen binds to several of these receptors, links them together and is taken into the cell by receptor-mediated endocytosis •Small molecules are not antigenic because they cannot link multiple receptors together –B cell processes (digests) the antigen •Links some of the epitopes to its MHC-II proteins –Displays these on the cell surface –Usually B cell response goes no further unless a helper T cell binds to this Ag–MHC protein complex •Bound T\_H cell secretes interleukins that activate B cell –Triggers clonal selection * B cell mitosis gives rise to a battalion of identical B cells programmed against the same antigen * Most differentiate into plasma cells –Larger than B cells and contain an abundance of rough ER •Plasma cells secrete antibodies at a rate of 2,000 molecules per second during their life span of 4 to 5 days –First exposure to antigen triggers production of IgM antibodies, later exposures to the same antigen, IgG –Antibodies travel through body in blood, other body fluids

Answer 200

–Antibodies bind to antigen, render it harmless, “tag it” for destruction

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–Some B cells differentiate into memory cells

Answer 202

neutralization, complement fixation, agglutination, and precipitation

Answer 203

–Antibodies mask pathogenic region of antigen

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–IgM or IgG bind to antigen, change shape and initiate complement binding which leads to inflammation, phagocytosis, immune clearance, or cytolysis –Primary defense against foreign cells, bacteria, and mismatched RBCs

Answer 205

–Antibody has 2 to 10 binding sites; binds to multiple enemy cells, immobilizing them from spreading –Enhances phagocytosis by creating “bigger bites”

Answer 206

–Antibody binds antigen molecules (not cells); creates antigen–antibody complex that precipitates, allowing them to be removed by immune clearance or phagocytized by eosinophils

Answer 207

1. Primary: immune reaction brought about by the first exposure to an antigen 2. Secondary: if reexposed to the same antigen

Answer 208

•Primary response leaves one with an immune memory of the antigen –During clonal selection, some of the cells becomes memory B cells –Found mainly in germinal centers of the lymph nodes –Mount a very quick secondary response

Answer 209

•—if reexposed to the same antigen –Plasma cells form within hours –IgG titer rises sharply and peaks in a few days –Response is so rapid that the antigen has little chance to exert a noticeable effect on the body –No illness results –Low levels of IgM also secreted (then quickly decline) –IgG remain elevated for weeks to years * Conferring long-lasting protection * Memory does not last as long in humoral immunity as in cellular immunity

Test 2: Blood Vessels & Lymphatic System FINAL Flashcards

(240 cards)