Test 4 Urinary Flashcards Preview

BioChem IPAP 3-17 > Test 4 Urinary > Flashcards

Flashcards in Test 4 Urinary Deck (19):
1

What artery brings blood to the kidney's vasculature for filtration?

Renal Artery

2

The Renal Corpuscle and Convoluted tubules of the nephron are found within what portion of the kidney?

Renal Cortex

3

What structures make up the Renal Corpuscle?

-Bowman's Capsule
-Glomerulus

4

The Loop of Henle and collecting ducts of the nephron are found within what portion of the kidney?

Renal Medulla

5

What are the names of the two types of nephrons?

-Juxtamedullary Nephron
-Cortical Nephron

6

What is the difference between the Loops of Henle of Juxtamedullary Nephrons and Cortical Nephrons?

-Juxtamedullary: Extend deep into medulla and has thin Ascending limb portion
-Cortical: Do not Extend deep into Medulla and do not have a thin portion of the ascending limb

7

What is the basic structural and functional unit of the kidney? Approx. how many per kidney?

Nephron
1 Million

8

Where is blood filtered and in which produces filtrate that ultimately leads to the formation of urine?

Renal Corpuscles

9

What are the 7 functions of the Kidneys?
(A WET BED)

-A: maintain ACID-Base Balance
-W: Maintain Water Balance
-E: Electrolyte Balance
-T: Toxin Removal
-B: Blood Pressure Control (RAAS)
-E: Making Erythropoietin
-D: Vitamin D Metabolism

10

What are the negatively-charged "openings" of the endothelial lining, that allow anything smaller than a RBC through, called?

Fenestrations

11

What Glomerular structure is the layer of extracellular matrix secreted by the epithelial cells, on which the epithelium sits?

Basal Lamina

12

The Glomerular Basal Lamina is made up of how many layers and what are the names of the layers in which forms an efficient and highly selective, sieve-like filter?

3
-Lamina Rara Interna
-Lamina Densa
-Lamina Rara Externa

13

The Lamina Rara Interna and Lamina Rara Externa are lined with what?

Negatively-Charged
GLYCOSAMINOGLYCANS
(Including HEPARIN)

14

The Lamina Densa is composed of what?

-Filamentous TYPE IV COLLAGEN, (Kinked sheet collagen pattern, no regular glycines)
-Glycoprotein LAMININ that cross-links TYPE IV COLLAGEN

15

What are the specialized epithelial cells covering (wrap around) and fusing with the basement membrane of the glomerulus and contain foot processes that interdigitate with nearby podocytes in the kidney, called?

Podocyte

16

What are the names of the proteins and negatively-charged glycoprotein that line and stabilize SLIT DIAPHRAGMS?

Podocin- Protein
Nephrin- Protein
Glycocalyx- Glycoprotein

17

What can be caused by defects in Podocin (Protein), one of the proteins that line and stabilize slit diaphragms?

Minimal-Change Disease (Nephropathy)

18

What will the loss of podocyte foot processes lead too?

Proteinuria and water imbalance--> leads to swelling of body (edema)

19

What else does the slit diaphragms limit passage of?

Negatively-charged and/or medium-sized molecules (e.g. albumin)