TEST II Flashcards
MULTIPLE CHOICES
what clotting factors plays a role in clot formation in vitro, but not in vivo?
XIIa
What initiates in vivo coagulation by activation of factor VII
The tissue factor
what is the charactristic of vitamin k
It is required for carboxylation of glutamate residues of some coagulation factors
which protein is the primary inhibitor of the fibrinolytic system
alpha 2- antiplasmin
Thrombocytopenia may be associated with
Hyperslenism
Asprin prevents platelet aggregation by inhibiting the action of which enzyme?
Cyclo-Oxygenase
Normal platelet adhesion depends upon what
Glycoprotein IIb and IIIa complex
Bernard-soulier syndrome is associated with
Thrombocytopenia giant platelets
several hours after birth, a baby boy develops petechiae and purpura and a hemorrhagic diathesis. The platelet count is 18 x 109/L. What is the most likely explanation for the low platelet count?
Petechiae are pinpoint, round spots that form on the skin due to bleeding. They can appear as small red or purple patches just under the skin.
Purpura are red, purple, or brown blood spots that appear on your skin
Neonatal DIC
Neonatal Disseminated Intravascular Coagulation (DIC) is a serious condition characterized by excessive activation of the coagulation system in newborns
What prevent platelet aggregation
- Prostacyclin
what plasma protein is essential for platelet adhesion
vWF
Platelet aggregation refers to
Platelets stickig together
proteins present in both plasma and alpha graules include
- fibrinogen
- vWF
- Factor V
Clinical profiling instruments can generate one of the following parameters which manual methods cannot determine in blood samples
mean platelet volume
The normal peripheral platelet count is
150-400 x10^9/L
