TEST 1 . MULTIPLE CHOICE

Question 1

What virus causes lymphoid malignancies in humans

Answer 1

Epstein-Bar virus

Question 2

Tumor suppresor genes causes cancers such as leukemia when mutations result in

Answer 2

Failure to prevent malignant process

Question 3

what is a cellular abnormality produced by oncogenes

Answer 3

Acceleration of DNA catabolism

Question 4

Oncogenes are said to act in a dominant fashion because

Answer 4

A mutation in a single allele is sufficient for malignancy to develop

Question 5

Compared with autologous bone marrow transplantation, allogeneic transplantation has

Answer 5

better long term success

Question 6

Chemotherapeutic agents are divided into which two major subgroups

Answer 6

phase specific
phase non specific

Question 7

Qualitative and quantitative neutrophil changes noted in response to infection include

Answer 7

neutropenia
toxic granulation
vacuolization

Question 8

The WHO classification requires what percentage for the blast count in the blood or bone

Answer 8

At least 20%

Question 9

neutropenia is present in patients with which absolute count

Answer 9

<1.5*10^9/L

Question 9

A m:e (myeloid:erythroid ration) of 10:1 is mostly seen in

Answer 9

Leukemia

Question 10

In addition to morphology, cytochemistry, and immunophenotyping, the WHO classification of Myelo- and lymphoproliferative disorders is based upon which characteristic?

Answer 10

Cytogenetic abnormalities

Question 11

Which AML cytogenetic abnormality is associated with acute myelomonocytic leukemia
with marrow eosinophilia under the WHO classification of AML with recurrent genetic
abnormalities?

Answer 11

AML with inv

Question 12

Which of the following leukemias are included in the 2008 World Health Organization classification of myeloproliferative neoplasms?

Answer 12

Chronic myelogenous leukemia (CML)
Chronic neutrophilic leukemia (CNL)
Chronio eosinophilic leukemia (CEL)

Question 13

Frequent phlebotomy in polycethemia vera patients may lead to

Answer 13

iron deficiency anaemia

Question 14

in essential thrombocytopenia the platelets are

Answer 14

increased in number and fuctionality abnormal

Question 15

Which of the following cells is considered pathognomonic for Hodgkin’s disease?

Answer 15

Reed- sternberg cells

Question 16

Which of the morphological findings are characteristics of reactive lymphocytes

Answer 16

high nuclear: cytoplsmic ration
prominent nucleoli
basophilic cytoplasm

Question 17

Which type of anaemia is ussually present in a patient with acute leukemia

Answer 17

Normocytic, Normochromic

Question 17

Auer rods may be seen in all of the following

Answer 17

acute myelomonocytic leukemia (M4)
acute myeloid leukemia leukemia without maturation (M1)
acute promyelocytic leukemia (M3)

Question 18

The basic pathophysiological mechanisms responsible for producing signs and symptoms in leukemia include all of the following except

Answer 18

Decreased erythropoietin production

Question 18

In leukemia which term decribes a peripheral blood finding of leukocytosis with a shift to the left, accompanied by nucleated red cells

Answer 18

Leukoerythroblastosis

Question 19

Which type of acute myeloid leukemia is called the true monocytic leukemia and follows an acute or sub acute course charcterized by monoblasts, promonocytes and monocytes

Answer 19

Acute monocytic anaemia

Question 19

In which age group does acute lymphoblastic leukemia occur with the highest frequency

Answer 19

1-15 years

Question 20

Disseminated intravascular coagulation (DIC) is mostly often associated with which of the following types of acute leukemia

Answer 20

Acute promyelocytic leukemia

Question 21

In Myelofibrosis, the characteristic abnormal red blood cell morphology is that of

Answer 21

Tear drop cell

Question 21

PV is characterized by

Answer 21

Absolute increase in total red cell mass

Question 22

Features of secondary polycynthemia incude all of the foloowing except

Answer 22

splenomegaly

Question 22

The erythrocytosis seen in relative polycythemia occurs because of

Answer 22

Decreased plasma volume of circulating blood

Question 23

In PV, what is characteristically seen in the peripheral blood?

Answer 23

Pancytosis

Question 24

The leukocyte alkaline phosphatase (LAP) stain on a patient gives the following results: 10(0) 48(1+) 38(2+) 3(3+) 1(4+). Calculate the LAP score. The LAP score is calculated as: (the number of 1+ cells x 1) + (2+ cells x 2) + (3+ cells> 3) + (4+ cells x 4).

Answer 24

137

Question 25

Which of the following occurs in idiopathic Myelofibrosis (IMF)?

Answer 25

All of these options

Question 25

CML is distinguished from leukemoid reaction by which of the following?

Answer 25

CML: low LAP; leukemoid: high LAP

Question 26

What influence does the Philadelphia (Ph1) chromosome have on the prognosis of patients with chronic myelogenous leukemia?

Answer 26

The prognosis is better if Ph1 is present

Question 27

Which of the following is (are) commonly found in CML?

Answer 27

An increase in basophils

Question 27

In which of the following conditions does LAP show the least activity?

Answer 27

CML

Question 28

A striking feature of the peripheral blood of a patient with CML is a:

Answer 28

Presence of granulocytes at different stages of development

Question 29

Which of the following is often associated with CML but not with AML?

Answer 29

Splenomegaly

Question 30

The JAK2(V617F) mutation may be positive in all of the following chronic myeloproliferative disorders Except

Answer 30

CML

Question 30

All of the following are major criteria for the 2008 WHO diagnostic criteria for essential thrombocythemia Except:

Answer 30

Sustained platelet count >600 x 109/L

Question 31

A patient in whom CML has previously been diagnosed has circulating blasts and promyelocytes that total 30% of leukocytes. The disease is considered to be in what phase?

Answer 31

Transformation to acute leukemia

Question 32

Features of secondary polycethemia include all of the following except

Answer 32

Splenomegaly