The Pituitary Gland Flashcards

(42 cards)

1
Q

How is the hypothalamus connected to the pituitary gland ?

A

Via the infundibulum

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2
Q

What portion of the hypothalamus is connected to the endocrine system?

A

The anterior pituitary

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3
Q

Where is the pituitary gland located?

A

The pocket of the sphenoid, directly below the hypothalamus

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4
Q

Where are neurohormones released from?

A

Posterior Pituitary and Hypothalamus

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5
Q

Where are classic endocrine hormones released?

A

Anterior Pituitary

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6
Q

Where are tropic and non-tropic hormones released?

A

The hypothalamus and the anterior pituitary

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7
Q

What are tropic hormones?

A

Neurohormones secreted into capillaries travelling into the anterior pituitary which govern release of anterior pituitary hormones

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8
Q

What are non-tropic hormones?

A

Neurohormones produced in hypothalamus and travel to posterior pituitary where they are released into blood

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9
Q

What is the function of tropic hormones?

A

Bind to receptors on anterior pituitary and stimulate/inhibit release of AP hormones

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10
Q

Name 5 hypothalamic releasing hormones

A

TRH, CRH, GHRH, GnRH, PRH

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11
Q

Name 2 hypothalamic inhibiting hormones

A

GHIH and Dopamine

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12
Q

What is the Hypothalamo-Hypophyseal portal system?

A

A network of tiny vessels which transfer trophic hormones from hypothalamus to anterior pituitary

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13
Q

Where are hormones released within they hypothalamo-hypohyseal portal system?

A

At the median eminence

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14
Q

What is the origin of anterior pituitary tissue?

A

Epithelial tissue

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15
Q

What is the origin of posterior pituitary tissue?

A

Neural tissue

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16
Q

Where is the anterior pituitary connected to?

A

The hypothalamus via the capillary portal system

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17
Q

Where is the posterior pituitary connected to?

A

Neural connection to the hypothalamus

18
Q

How does the hypothalamus control the production of AP hormones?

A

By releasing or inhibiting trophic hormones that stimulate or inhibit hormone production from the AP

19
Q

Where does prolactin act and what is its function?

A

Breast

Results in lactation (Direct)

20
Q

Where does TSH act and what is its function?

A

Thyroid

Results in TH release (tropic)

21
Q

Where does adrenocorticotropic hormone act and what is its function?

A

Ad. Cortex

Results in Cortisol Release (Tropic)

22
Q

Where does growth hormone act and what is its function?

A

Liver

Results as an IGF-1* release (tropic) and tissue metabolism (direct)

23
Q

Where does FSH and LH act and what are their functions?

A

Gonads

Regulate reproductive function (direct) and sex hormone release (tropic)

24
Q

Where does AP feedback control occur?

A

Hypothalamus, AP and Target Endocrine Cell

25
What hormones does the PP release?
Vasopressin and Oxytocin
26
Where are PP hormones synthesised?
Magnocellular Neurons in the hypothalamus
27
Where do axons of the infundibulum project?
The posterior pituitary
28
Describe how hormones of the PP synapse?
Terminals end directly on capillaries
29
What is the main function of ADH?
Regulates water balance
30
When is ADH released?
When plasma osmolarity or plasma volume/blood pressure is increased
31
What is the site/mode of action of ADH?
Kidney collecting ducts - increases water reabsorption Vascular Smooth Muscle - increases blood pressure
32
What is the main function of oxytocin?
Milk ejection and uterine contraction
33
When is oxytocin released?
Labour or suckling
34
What is the site/mode of action of oxytocin?
Milk duct smooth muscle - Contracts muscle and ejects milk Uterine smooth muscle - child birth
35
Define hyposecretion?
Too little secreted
36
Define hypersecretion?
Too much secreted
37
Define Hyporesponsiveness
Reduced response of target cell. Relates to alteration in hormone receptor, post-receptor disorder or failure of metabolic activation of hormone
38
Define Hyperresponsiveness
Increased response of target cell. Due to permissive effects
39
Define a primary disorder
the defect lies within the cell that secretes the hormone
40
Define a secondary disorder
Where there is too much or too little trophic hormone from pituitary
41
Define a tertiary disorder
Relates to a hypothalamic defect
42
What is a trophic hormone?
A hormone which controls the secretion of another hormone