Theophylline Flashcards
1
Q
What’s theophylline used for?
A
A bronchodilator for asthma or COPD
2
Q
Theophylline desired plasma conc?
A
10-20mg/L
Above 20mg/L severe side effects e.g hypokalaemia
Narrow therapeutic index
3
Q
Theophylline side effects (6)
A
Tachycardia, palpitation, nausea, GI, Headache, convulsions
4
Q
Theophylline monitoring
A
Plasma theophylline conc, Lung function tests
5
Q
Theophylline interactions
A
Quinolones - Increased risk of convulsions
St Johns Wort - Reduced plasma conc.
Rifampicin - Reduced plasma conc.
Cimetidine - Increased plasma conc.
Fluconazole - Increased plasma conc.
