Theories of ageing Flashcards
(12 cards)
What is Programme Theory
Ageing follows a biological timetable or internal biological clock
What is damage/error theory
A result of internal or external assults that damage cells or organs so they can no longer function properly
What is the hayflick limit?
The maximum number of times a cell can reproduce itself
What is endocrine Theory, and what factors increase longevity?(2)
Biological clock acts through hormones to control the pace of ageing
Caloric restriction increases longevity
Delayed growth/blocking reproduction can increase life span
What is immunologic Theory?
Age associated decline in immune function leading to an increase vulnerability to disease and death
Decrease in T-cells—> tumour surveillance decreases with age
What is damage theory
Wear and tear, years of damage to cells tissues and organs eventually wears them out killing both the cells and the body
What is rate of living Theory
The greater an organisms basal metabolic rate the shorter the life span
What is the Cross-linking theory?
Accumulation of cross-linked proteins damages cells and tissue slowing doen bodily processes
What is free-radical theory
During ageing agame produced by free radicals cause cells and organs to stop functioning
What is the mitochondrial theory of ageing?
(4)
Mitochondria
Reactive oxygen species
Oxidative Damage & mDNA mutations
Mitochondrial dysfunction
-> AGEING
What is Catastrophe Theory?
Any damage to the enzyme systems that synthesise proteins in the body results in faulty proteins sunthesis
Faulty proteins continue to accumulate in the cell
When enough damage accumulates this may result in cell malfunctioning leading to death
What is a somatic muation?
Genetic muation occur and accumulate with age in the somatic cell causing the cell to
- deterioate
- malfunction
