This or That

Question 1

increased􀁱 thickness of stratum corneum

Answer 1

Hyperkeratosis

Question 2

Hyperkeratosis with retention of nuclei in

stratum corneum

Answer 2

parakeratosis

Question 3

increased thickness of stratum granulosum

Answer 3

hypergranulosis

Question 4

epidermal accumulation of edematous fluid in intercellular space

Answer 4

spongiosis

Question 5

acantholysis

Answer 5

separation of epidermal cells

Question 6

example of hyperkeratosis

Answer 6

psoriasis, calluses

Question 7

example of parakeratosis

Answer 7

psoriasis

Question 8

example of hypergranulosis

Answer 8

lichen planus

Question 9

example of spongiosis

Answer 9

eczematous dermatitis

Question 10

example of acantholysis

Answer 10

pemphigus vulgaris

Question 11

example of acanthosis

Answer 11

acanthosis nigricans

Question 12

epidermal hyperplasia (increase spinosum)

Answer 12

acanthosis

Question 13

Benign, painful, red-blue tumor, commonly under fingernails. Arises from modified smooth
muscle cells of the thermoregulatory glomus body.

Answer 13

Glomus tumor

Question 14

-wear and tear
-pain with use
-Osteophytes (bone spurs), joint space narrowing,
subchondral sclerosis and cysts. Synovial
fluid non-inflammatory (WBC < 2000/mm3).
Involves DIP (Heberden nodes ) and PIP
(Bouchard nodes), and 1st CMC; not MCP

Answer 14

osteoarthritis

Question 15

Progressive symmetric proximal muscle weakness, characterized by endomysial inflammation with
CD8+ T cells. Most often involves shoulders.

Answer 15

polymyositis

Question 16

But also involves malar rash (similar to SLE), Gottron papules,
heliotrope (erythematous periorbital) rash , “shawl and face” rash , “mechanic’s hands.” 􀁱increased risk
of occult malignancy. Perimysial inflammation and atrophy with CD4+ T cells.

Answer 16

dermatomyositis

Question 17

-pain improves with use
-morning stiffness in the morning
-Erosions, juxtaarticular osteopenia, joint space
narrowing, soft tissue swelling, subchondral
cysts. Deformities include subluxation, fingers
with ulnar deviation, swan neck, and
boutonniere. Synovial fluid inflammatory
(WBC > 2000/mm3). Involves MCP, PIP,
wrist; not DIP or 1st CMC.

Answer 17

rheumatoid arthritis

Question 18

neutrophils are the primary cells responsible for the intense inflammatory response seen in patients with gout; the neutrophils phagocytize the urate crystals . In what pathology?

Answer 18

gout

Question 19

Acute inflammatory monoarthritis caused by precipitation of monosodium urate crystals in
joints

Answer 19

gout

Question 20

Deposition of calcium pyrophosphate crystals within the joint space. Occurs in patients > 50 years
old; both sexes affected equally. Usually idiopathic, sometimes associated with hemochromatosis,
hyperparathyroidism, joint trauma

Answer 20

calcium pyrophosphate deposition disease

Question 21

Pain and stiffness in shoulders and hips, often with fever, malaise, weight loss. Does not cause
muscular weakness. More common in women > 50 years old; associated with giant cell (temporal)
arteritis.

Answer 21

Polymyalgia rheumatica

Question 22

What MSK pathology has normal acute phase reactants and other inflammatory markers?

Answer 22

fibromyalgia

Question 23

Most commonly seen in females 20–50 years old. Chronic, widespread musculoskeletal pain
associated with stiffness, paresthesias, poor sleep, fatigue, cognitive disturbance (“fibro fog”).

Answer 23

fibromyalgia

Question 24

• age <25
• chunk of bone
• benign
• MC benign bone tumor

Answer 24

osteochondroma

Question 25

- age 10-20 - malignant * codman's triangle * sunburst * MC primary malignant of kids

Answer 25

osteosarcoma

Question 26

*giant cell tumor * age 20-40 *soap bubble lesions (epiphyseal end of long bones)

Answer 26

osteoclastoma

Question 27

* age <15 * 11:22 translocation * malignant * onion skin

Answer 27

Ewing sarcoma