Thomas 2

Question 1

Degaralix is a

Answer 1

GnRH antagonist

Question 2

Leuprolide is a

Answer 2

GnRH agonist

Question 3

Goserelin is a

Answer 3

GnRH agonist

Question 4

Finasteride blocks

Answer 4

5-alpha reductase

Question 5

Flutamide blocks

It (is/is not) a steroid

Answer 5

Androgen receptor complex

is not

Question 6

Cyptroterone blocks

It (is/is not) a steroid

Answer 6

Androgen receptor complex

is

Question 7

Spironolactone blocks

Answer 7

Androgen receptor complex

Question 8

nilutamide blocks

It (is/is not) a steroid

Answer 8

Androgen receptor complex

Is not

Question 9

bicalutamide blocks

It (is/is not) a steroid

Answer 9

Androgen receptor complex

Is not

Question 10

used to treat BPH, but not good for prostate cx

Answer 10

finasteride

Question 11

Indication for thiotepa

Answer 11

Bladder cancer, intravesicular

Question 12

Indication for mitomycin

Answer 12

Bladder cancer, intravesicular

Question 13

Indication for valrubicin

Answer 13

Bladder cancer, intravesicular

Question 14

Indication for Methotrexate

Answer 14

Bladder cancer, systemic

Question 15

Indication for vinblastine

Answer 15

Bladder cancer, systemic

Question 16

Indication for doxorubicin

Answer 16

Bladder cancer, systemic

Question 17

Indication for carboplatin

Answer 17

Bladder cancer, systemic

Question 18

Indication for IL-2

Answer 18

renal cell cancer

Question 19

indication for sunitinib

MOA for sunitinib

Answer 19

renal cell carcinoma

inhibits receptor tyrosine kinases (VEGF, PDGF)

Question 20

Indication for sorafenib

MOA

Answer 20

Renal Cell Carcinoma

Inhibits VEGF-Receptor

Question 21

Indication for Bevacizumab

MOA

Answer 21

Renal Cell carcinoma

mAb against VEGF

Question 22

Indication for Pazopanib

MOA

Answer 22

Renal Cell Carcinoma

Inhibits tyrosine kinase of VEGFR

Question 23

Indication for Aztreonam

Answer 23

enterobacter and pseudomonas

resistant to plasmid beta lactamase

Question 24

ok for PCN allergies

Answer 24

aztreonam

Question 25

urinayr catheter ass UTI is usu caused by AAA and should be treated with BBB

Answer 25

A. enterobacter (G-) | B. aminoglycosides

Question 26

aminoglycosides bind to

Answer 26

30S ribosomal subunit

Question 27

major side effects of aminoglycosides (2) Which is reversible and which is irreversible

Answer 27

nephrotox and ototox nephro - reversible Ototox - irreversible

Question 28

Fanconi's can be the result from

Answer 28

tetracyclines

Question 29

tetracyclines can produce (3)

Answer 29

renal tubular acidosis azotemia fanconi's

Question 30

tetracyclines are excreted by

Answer 30

kidneys (except doxy)

Question 31

E. coli is resistant to

Answer 31

doxycycline

Question 32

An apparent UTI caused by STD is treated with

Answer 32

doxycycline and azythromycin

Question 33

Used for UTI prophylaxis

Answer 33

Bactrim

Question 34

How does Bactrim work?

Answer 34

Blocks folate synthesis

Question 35

Wierdo quinolones for G (-) only

Answer 35

Nalidixic Acid | Cinoxacin

Question 36

How do quinolones work on G-?

Answer 36

inhibit DNA gyrase

Question 37

How do quinolones work on G+?

Answer 37

Inhibit topoIV

Question 38

used for prophylaxis of chronic UTI. Metabolized to formaldehyde spontaneously at low urine pH

Answer 38

Methenamine

Question 39

Effective against G(+) and G(-) E. Coli, but not Proteus, Pseudomonas, Enterobacter, and Klebsiella

Answer 39

Nitrofurantion

Question 40

Primary treatment of schistosomes

Answer 40

Praziquantel

Question 41

secondary treatment of S. Mansoni

Answer 41

Oxamniquine

Question 42

Secondary treatment of S. Haematobium

Answer 42

Metrofinate

Question 43

Secondary treatment of S. Japonicum

Answer 43

None

Question 44

schistosome found in South America, Africa, Middle east infects Liver, spleen, GI

Answer 44

Mansoni

Question 45

schistosome found in Africa, Middle East. Infects Urinary and genital tracts

Answer 45

Haemotobium

Question 46

schistosome found in China and Philippines. Infects liver, spleen, GI

Answer 46

Japonicum

Question 47

for schistosoma; SE: causes muscular contraction and paralysis

Answer 47

Praziquantel

Question 48

for schistosoma; must be activated to dichlorovos, which inhibits Ach

Answer 48

metrifonate for Haematobium

Question 49

For schistosoma; converted to an ester, which dissociates and results in electrophilic reactant alkylates schistosome DNA

Answer 49

Oxamniquine For mansoni