Thrombocytopenia Flashcards
(21 cards)
Normal Platelet Count:
150,000–400,000/µL
Bleeding Risk:
o <50,000/µL → Risk of
o <10,000/µL → risk
bleeding , Spontaneous bleeding
Platelet receptor that binds fibrinogen or vWF
GPIIb/IIIa
Platelet surface receptor that binds vWF
GPIb
Common features of Platelet dysfunction
Skin & mucosal bleeding (petechiae, purpura, epistaxis)
Common features of Coagulation factor
deficiency
Joint & deep tissue bleeding (hemarthrosis, muscle hematoma )
Causes of Thrombocytopenia
- Decreased Platelet Production
- Increased Platelet Destruction
- Increased Platelet Sequestration
- Dilutional Thrombocytopenia
Decreased Platelet Production seen in
Bone marrow failure: Aplastic anemia, leukemia, MDS
Bone marrow suppression: Chemotherapy, radiation
Nutritional deficiencies: B12, folate deficiency
Increased Platelet Destruction seen in
Immune-mediated: ITP, drug-induced (heparin, quinine)
Non-immune: DIC, TTP, HUS
Increased Platelet Sequestration like in
Hypersplenism (Liver disease, portal hypertension)
Dilutional Thrombocytopenia like in
Massive transfusion syndrome
متى أنا بلجا لعمل platelet transfusion ؟
Active bleeding
<50000
متى أنا بلجا لعمل platelet transfusion ؟
Surgery (major)
<50,000/µL
متى بلجا to platelets transfusion ؟
Surgery (CNS, ophthalmic)
<100,000/µL
متى أنا بلجا لعمل platelet transfusion
Prophylaxis (no bleeding)
<10,000/µL
GPIb deficiency (platelets cannot bind vWF)
Bernard-Soulier Syndrome
Findings: Thrombocytopenia, giant platelets
. Bernard-Soulier Syndrome
. Bernard-Soulier Syndrome rout of inherited
The Autosomal recessive
Cause: GPIIb/IIIa deficiency (platelets cannot aggregate)
Glanzmann’s Thrombasthenia
Glanzmann’s Thrombasthenia
Glanzmann’s Thrombasthenia
Inheritance of Glanzmann’s Thrombasthenia
Autosomal recessive
