Thrombolytics

Question 1

thrombolytics MOA

Answer 1

Modified forms of tPA that bind to fibrin and convert plasminogen to plasmin

Question 2

route of administration for all thrombolytic drugs

Answer 2

all IV

Question 3

thrombolytic Drugs (3)

Answer 3

Alteplase
Reteplase
Tenecteplase

Question 4

Thrombolytic drugs main clinical use

Answer 4

STEMI

Question 5

Alteplase can be used in STEMI, and also in _____.

Answer 5

PE, Ischemic stroke, open central venous access devices

Question 6

Why can tenecteplase be advantageous?

Answer 6

might offer advantages due to fewer non cerebral bleeding events and ease of use (single bolus)

Question 7

Absolute contraindications for use of thrombolytic drugs

Answer 7

prior intracranial hemorrhage, known structural cerebral vascular lesion, known malignant intracranial neoplasm, ischemic stroke within 3 months, suspected aortic dissection, active bleeding or bleeding diathesis, significant closd head trauma or faial trauma in last 3 months

Question 8

What is timing so important for thrombolytic drugs

Answer 8

if it is administered within first 3 hours you have a lower mortality rate