thrombophilia

Question 1

inherited causes of thrombophilia

Answer 1

gain of function polymorphisms:
- factor V leiden (most common)
- prothrombin gene mutation (second most common)
deficiencies of naturally occurring anticoagulants
- antithrombin III deficiency
- protein C deficiency
- protein S deficiency

Question 2

acquired causes of thrombophilia

Answer 2

antiphospholipid
drugs: COCP

Question 3

what is factor V leiden

Answer 3

due to a gain of function mutation in the factor V leiden protein (activated protein C resistance)