Thyroid meds Flashcards Preview

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Flashcards in Thyroid meds Deck (39):
1

Take home message from class: Hypothryroidism

No problem! Here, take this pill.

2

Take home message from class: Hyperthyroidism

Shit show! Tape the endocrinologist's phone number to your door and hide under your desk until the patient goes away.

3

Synthroid: class

Thyroid agent (T4)

4

Synthroid: MOA

T4 replacement

5

Synthroid: indication

Hypothyroidism, thyroid cancer

6

Synthroid: side effects

Decreased bone density

7

Synthroid: contraindication

AMI, uncontrolled adrenal insufficiency

8

Synthroid: Dx-Dx

Amiodarone (contains a lot of iodine)
High dose BBs (decrease T4 --> T3 conversion)

9

How long do you need to wait to see if any Synthroid dose change has worked?

6-8 weeks.

10

Liothyronine: class

Thyroid agent (T3)

11

Liothyronine: MOA

T3 replacement

12

Liothyronine: indication

Hypothyroidism refractory to T4 replacement

13

Liothyronine: side effect

Dysrhythmias, HOTN

14

Liothyronine: contraindication

AMI, uncontrolled adrenal insufficiency

15

Liothyronine: Dx-Dx

Anorexic drugs, DM drugs, tricyclics

16

Liothyronine has a short t1/2

Requires BID-TID dosing

17

Radioactive iodine: class

Anti-thyroid agent

18

Radioactive iodine: MOA

Thyroid cell death in 6-8 weeks

19

Radioactive iodine: indication

Thyroid ablation without surgery

20

Radioactive iodine: side effects

Exacerbation of buggy-outty eyes; painful thyroiditis

21

Radioactive iodine: contraindications

Pregnancy, nursing

22

What are we expecting to occur with radioactive iodine

Hypothyroidism

23

Methimazole: class

Anti-thyroid agent

24

Methimazole: MOA

Blocks oxidation of iodine, preventing T4/T3 synthesis. Does not affect circulating T4/T3.

25

Methimazole: indication

Hyperthyroidism

26

Methimazole: side effects

Decr WBC, aplastic anemia, nephrotic syndrome

27

Methimazole: contraindication

Bone marrow suppression

28

Prednisone: class

Glucocorticoid

29

Prednisone: MOA

Suppresses adrenal function in high doses; decr WBC migration; alters protein synthesis.

30

Prednisone: indication

Oh lots...it's good for what ails you if you need your immune system suppressed.

31

Prednisone: side effects

HPA-axis suppression, psych disturbances, osteoporosis, fluid retention, muscle weakness.

32

Prednisone: contraindication

Systemic fungal infection; concomitant use with vaccines

33

Prednisone is a prodrug. What is the active drug?

Prednisolone.

34

What is another glucocorticoid that is 7-10x more potent than Prednisone?

Dexamethasone

35

______mg of Dexamethasone = _______mg of Prednisone.

0.75
5.0

36

Fludrocortisone: class

Mineralcotricoid

37

Fludricortisone: MOA

Promotes distal renal tubule absorption of Na+ and secretion of K+.

38

Fludricortisone: indication

Addison's disease; refractory orthostatic HOTN

39

Fludrocortisone: side effects

CHF, hyperglycemia, muscle weakness, may inhibit HPA-axis.