Tissue Repair Flashcards Preview

Pathology > Tissue Repair > Flashcards

Flashcards in Tissue Repair Deck (29)
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1
Q

Broad descriptions of Acute inflammation

A
  • fast
  • mainly consists of neutrophils
  • usually mild and does not destroy self tissues
  • has prominent local & systemic signs
2
Q

Broad descriptions Chronic inflammation

A
  • slow
  • produces monocytes/macrophages and B/T cells
  • usually severe and damages self tissue
  • little systemic & local signs
3
Q

Calor

A

Heat

4
Q

Rubor

A

Redness

5
Q

Tumor

A

Swelling

6
Q

Dolor

A

Pain

7
Q

Functio laesa

A

Loss off. Function

8
Q

Specific descriptions of acute inflammation

A

Dilation of small vessels

Increase permeability of microvasculature

Emigration of leukocytes from microcirculation to the focus of injury

9
Q

Exudate

A

Extravascular fluid that contains cellular debris and lots of proteins

  • presence implies increased permeability of small blood vessels
10
Q

Purulent inflammation

A

Accumulation of exudate that forms pus

  • high concentration of leukocytes/ dead cell debris
  • caused by pyogenic pathogens.
11
Q

Ulcer

A

Shedding “stuffing” of surface of organ

12
Q

Outcomes of acute inflammation

A
  • complete resolution/regeneration
  • progression to chronic inflammation
  • healing via scarring/fibrosis
13
Q

Labile tissues

A

Tissues containing cells that are ALWAYS undergoing self-replication

14
Q

Stable tissues

A

Tissues containing cells that are capable of regeneration, but not always undergoing it

15
Q

Permanent tissues

A

No regeneration of cells.

16
Q

Steps of scar tissue formation

A
  • inflammation
  • angiogenesis
  • formation of granulation tissue
  • ECM remolding/ scar formation
17
Q

TNF-B

A

Most importation cytokine to granulation tissue formation

18
Q

Primary union

A

Regeneration w/ mild scaring

19
Q

Secondary union

A

Regeneration w/extensive scarring

20
Q

keloid

A

Excessive ECM production causes large boundary-less scars

21
Q

Factors that impair tissue repair

A
Infection (most impactful)
Diabetes 
Steroids
Poor nutrition
Poor perfusion
Location, type and extent of injury
22
Q

Matrixmetalloproteinases (MMPs)

A

Most important molecule in formation and shrinkage of scars overtime

23
Q

Autophagy

A

Self digestion of intracellular organelles via lysosomes

-done in times of nutrient deprivation

24
Q

Mechanisms of intracellular accumulation

A

Abnormal metabolism

Mutations in protein folding/transport

Lysosome enzyme deficiencies

Inability to degrade phagocytosis pigments (carbon)

25
Q

Steatosis

A

Accumulation of triglycerides in parenchyma cells

26
Q

Alpha-1 antitrypsin deficiency

A

Mutation causing significant slowing of protein folding.

unfolded protein intermediates build up in ER

27
Q

Glycogenoses

A

Enzymes cant break down glucose

28
Q

Most common exogenous pigment

A

Carbon

  • build up called (anthracosis)
29
Q

Transudate

A

Fluid with low protein content & little or no cellular material.

  • presenceimplies hydrostatic imbalance across vessels w/normal permeability