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1
Q

How many platelets in a pheresis unit?

A

3 x10^11

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2
Q

Minimum donor intervals RBC

A

> =8 weeks for single unit whole blood donation

16 weeks if double unit by apheresis

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3
Q

bombay phenotype

A

Lacks H and secretor genes (hh, sese)

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4
Q

What sugar makes A antigen

A

Gal-NAc (N-acetylgalactosamine)

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5
Q

What sugar makes B antigen?

A

galactose (Gal)

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6
Q

what minor red cell antibody is most common cause of ABO discrepancy?

A

Anti-M (IgM)

*Redo ABO testing with M neg cells

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7
Q

What infection associated with Anti-I autoantibody?

A

Mycoplasma pneumonia

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8
Q

What infection associated with anti-i autoantibody?

A

infectious mononucleosis

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9
Q

PCH caused by what antibody?

A

Auto anti-P

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10
Q

Most common Weiner haplotype in caucasians?

A

R1 DCe

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11
Q

Most common Weiner haplotype in african americans?

A

R0 Dce

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12
Q

duffy negative confers resistance to what?

A

P. vivax

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13
Q

3 possibilities of RhD+ person showing anti-D?

A
  1. Variant/partial D (weak D testing will pick up)
  2. Auto-antibody (DAT +)
  3. Anti-LW antibody (DAT -)
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14
Q

Which antibodies show dosage

A

Kids, Monkeys (Rh) and MeN Show Dosage

–>Kidd, Rh, MNS and Duffy

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15
Q

Which antibody shows anamnestic response?

A

Kidd system (kids hide)

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16
Q

Which antibodies are enhanced by enyzmes?

A

Give sugar (CHO antigens) to Kids and monkeys (Rh) and they will jump

Rh
Kidd
Le, I, P, ABO

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17
Q

Which antibodies are decreased by enyzmes?

A

Daffy MeNS Lutheran Choir falls down

Duffy
MNS
Lu
Chido-Rogers

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18
Q

Which antibodies are unaffected by enyzmes?

A

Kell (doesn’t care)

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19
Q

RBC/Whole blood storage

A 
21 days (CPD/2D)
35 days (CPDA-1)
42 days (AS_
all @1-6C
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20
Q

Frozen RBC storage

A

10 yrs @-65C

24 hrs @1-6C after thaw

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21
Q

Washed RBC storage

A

24 hrs @1-6 C

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22
Q

Platelet storage

A

5 days @20-24 C (gentle agitation)

4 hours if pooled in open system

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23
Q

granulocyte storage

A

24 hrs 20-24C (no agitation)

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24
Q

FFP stroage

A

1 year @-18C
7 years @ -65C
24 hrs at 1-6 C after thaw

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25
Cryo storage
1 year @-18C | 6 hrs @20-24C after thaw (4 hours in pooled open system)
26
RBC quality control
HCT <80% all | >50g Hb in 95% (apheresis RBC)
27
Quality control leukoreduced RBCs
<5x10^6 WBCs in 95%, retain 85% of RBCs
28
Quality control cryo
factor 8>80IU, fibrinogen >150 mg
29
RBC storage lesion
Decreased 2,3 DPG Decreased ATP Decreased pH Decreased K+ in red cells, but increased K+ extracellularly
30
Minimum interval for donation apheresis platelet
Platelets apheresis <= 2 donations/week at least 2 days apart (<=24 in 12 mo period)
31
What color is Anti-A (ABO typing)?
Blue
32
What color is Anti-B (ABO typing)>?
yellow
33
Infectious tests required on donor blood
``` HBsAg Anti-HBc Anti-HCV HCV NAT Anti-HIV1/2 HIV1 RNA Anti-HTLV1 RPR ```
34
Calculation for how many units to test to find compatible one
Frequency Antigen neg blood in population=100-antigen frequency (multiply if multiple abs) 1/ frequency of antigen neg blood
35
Indications for emergent transfusion/exchange transfusion in sickle cell disease
``` Stroke Retinal artery occlusion Splenic sequestration crisis Acute chest syndrome Aplastic crisis Priapism ```
36
What classes of maternal alloantibodies cause HDFN?
IgG1, IgG3 or IgG4
37
Calculate RhIg dose
Vials=(maternal blood volume* %fetal cells in maternal blood)/30 If decimal .5 round up and add one
38
Maternal critical tiger for anti-kell
1:8
39
Contraindications to platelet transfusion
Relative—ITP | Absolute—HIT, TTP
40
how many mg of iron are in one unit (500cc) of whole blood?
200 mg
41
optimum CD34+ cell dose needed for hematopoietic recovery after allogenic peripheral blood stem cell transplant
2-5 x 10^6 cells/kg
42
optimum CD34+ cell dose needed for hematopoietic recovery after autologous peripheral blood stem cell transplant
2x10^8 cells/kg
43
What is the most immunogenic ABO blood group antigen?
A1
44
What is the mechanism of TRALI?
donor HLA antibodies reacting to recipient leukocytes
45
Whole blood irradiated expiration
28 days or original outdate (whichever is sooner)
46
Contents of cryoprecipitate
>150mg fibrinogen and 80 IU factor 8, also has factors 13 and vWF
47
What is dolichos biflorus?
Lectin, which has anti-A1 activity and used to distinguish A1 from A2
48
True or false. Recipients with anti-c or anti-e should not be given rh neg blood
True. Most common Rh neg genotype is r/r (dce, dce)
49
If anti-E is detected in serum, suspect presence of which other alloantibody?
Anti-c | *most with anti-E are R1/R1 (DCe) and have likely been transfused R2 blood (DcE)
50
Antibodies that commonly produce intravascular hemolysis
ABO, Kidd, P
51
What cells express HLA class II antigens?
B cells, macrophages and activated T cells
52
Causative agents transfusion transmitted sepsis platelets
Gram pos, esp staph spp
53
Transfusion transmitted sepsis causative organisms RBCs
``` Gram neg Yersinia enterocolitica Serratia liquifaciens Citrobacter Pseudomonas ```
54
what is evan's syndrome?
WAIHA + ITP
55
What is calculation for patient's total blood volume?
TBV=wt (kg) x 70mL/kg
56
Non-clinically significant alloantibodies
lutheran, lewis, M, N, P
57
How long is deferral for etretinate (tegison)?
Permanent
58
How long is deferral for acitretin (soriatane)
3 yrs
59
How long is deferral for isotretinoin (accutane)
30 days
60
How long is deferral for finasteride (proscar, propecia)
30 days
61
How long is deferral for dutasteride
6 mos
62
What does saliva neutralize?
ABO
63
what does hydatid cyst fluid neutralize
P1
64
what do pigeon eggs neutralize
P1
65
What does urine neutralize
Sda
66
What does serum neutralize
Chido, Rogers
67
What RBC morphology is associated with intravascular hemolysis
Schistocytes
68
What RBC morphology is associated with extra vascular hemolysis
Spherocytes
69
What complement components are considered anaphylotoxins
C3a and C5a
70
What type of hypersensitivity rxn are allergic TRs?
Type 1 IgE mediated
71
What classes of antibodies do not cross the placenta
IgG2 and IgM
72
What is ulex europaeus
Pectin with H antigen specificity

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