Topic 20 Glucocort Immunosuppre

Question 1

*All glucocorticoids are what?

Answer 1

immunosuppressive even as a single dose!

Question 2

glucocorticoids are what kind of steroid?

Answer 2

catabolic steroids

Question 3

glucocorticoids cause “feedback inhibition” of what?

Answer 3

glucocorticoid and thyroid -stimulating hormone production

Question 4

Glucocorticoid Side Effects (6)

Answer 4

• Bone density loss
• Myopathy
• ”Steroid rage” and personality changes
• Gastric ulcers
• Diabetogenic
• ”Moon Face & Humpback”

Question 5

Glucocorticoid risks for me/perfusion on pump

Answer 5

increase risk of infection, high blood pressure

Question 6

Addisons disease

Answer 6

when adrenal gland not produce sufficient steroid hormones (glucocorticoids and often mineralocorticoids).

Question 7

Cushing Disease

Answer 7

adrenal gland over working, increased secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary (secondary hypercortisolism)

Question 8

-Hydrocortisone

Answer 8

Solu-Cortef

Glucocorticoid Drugs

Question 9

-Dexamethasone

Answer 9

Decadron

Glucocorticoid Drugs

Question 10

-Methylprednisolone

Answer 10

Medrol

Glucocorticoid Drugs

Question 11

Glucocorticoid Drugs (5)

Answer 11

• Hydrocortisone (Solu-Cortef)
• Dexamethasone (Decadron)
• Prednisolone
• Prednisone
• Methylprednisolone (Medrol)

Question 12

D.O.C.s for moderate rejection episodes

Answer 12

Glucocorticoids

Question 13

Glucocorticoids have the *Most side-effects of any immunosuppressive category when given how?

Answer 13

at high doses over the long term?

Question 14

-Cyclosporin

Answer 14

Sandimmune

Calcineurin Inhibitors

Question 15

Tacrolimus

Answer 15

Prograf

Calcineurin Inhibitors
Orders of magnitude more potent than Cycylosporins.
•More nephrotoxic/less cardiotoxic than Cyclosporins.

Question 16

Calcineurin Inhibitors Drugs (2)

Answer 16

• Cyclosporin (Sandimmune)

- Tacrolimus (Prograf)

Question 17

mTOR Inhibitors

Answer 17

Sirolimus (Rapamune)

Question 18

Sirolimus

Answer 18

Rapamune

mTOR Inhibitor

Question 19

Antiproliferative Agents (3)

Answer 19

• Azathioprine (Imuran)
• Mycophenolate Mofetil (Cellcept)
• Mycophenolatesodium (Myfortic)

Question 20

Azathioprine

Answer 20

Imuran

Antiproliferative Agents
best on acute rather than chronic immunogenic response

Question 21

Mycophenolate Mofetil

Answer 21

Cellcept

Antiproliferative Agents
Mainly GI and bone-marrow suppression

Question 22

Mycophenolate sodium

Answer 22

Myfortic

Antiproliferative Agents
“slower-releasing” and “enterically-pleasing” form of Mycophenolate Mofetil

Question 23

*Monoclonal antibodies contain ONLY what type of antibody ???

Answer 23

one type of antibody that is derived from a

single cloned B-lymphocyte

Question 24

Dose-dependent nephrotoxicity, immune suppression (duh!), hepatotoxicity, cardiotoxicity, and many others

Answer 24

Cyclosporin

Calcineurin Inhibitors

Question 25

The “break-through” drug that allowed transplants to successfully occur

Answer 25

Cyclosporin Calcineurin Inhibitors

Question 26

The major T-cell activator

Answer 26

Calcineurin