Topic 4: Epithelial Tissue

Question 1

The connective tissue that underlies the epithelial lining the organs of the digestive, respiratory, and urinary systems is called..

Answer 1

Lamina Propria

Question 2

Name the 3 polarity of the Epithelial Tissue

Answer 2

Apical Domain
Basal Domain
Lateral Domain

Question 3

2 parts of the basement membrane

Answer 3

Basal Lamina
Reticular Lamina

Question 4

Tight Junction
- transmembrain Protein:
- cystoskeleton component:
- major function
- medical significance

Answer 4

• transmembrain Protein:
  CLAUDIN, OCCLUDIN, and ZO PROTEINS
• cystoskeleton component:
  ACTIN FILAMENTS
• major function
  SEALS ADJACENT CELLS AND CONTROLS THE PASSAGEWAY OF MOLECULES
• medical significance
  DEFECTS IN OCCLUDIN MAY COMRPISE THE FETUS BBB CAUSING MAJOR NEUROLOGICAL DISORDERS

Question 5

Adherens Junction (Zonula Adherens)

1.) Transmembrane Protein:
2.) Cytoskeleton:
3.) Function:
4.) Medical Significance:

Answer 5

1.) Transmembrane Protein:
- Cadherin Proteins, catenin complexes

2.) Cytoskeleton:
- actin filaments

3.) Function:
- supports the tight junction

4.) Medical Significance:
- loss of cadherin promotes tumor invasion and shift to malignancy

Question 6

Desmosomes (Macula Adherens)
1.) Transmembrane Protein:
2.) Cytoskeleton:
3.) Function:
4.) Medical Significance:

Answer 6

1.) Transmembrane Protein:
- desmogleins and desmocollin

2.) Cytoskeleton:
- intermediate filaments

3.) Function:
- provide cellular adhesion and strengthening tissue

4.) Medical Significance:
- may lead to dyshesive skin disorder

Question 7

Hemidesmosomes
1.) Transmembrane Protein:
2.) Cytoskeleton:
3.) Function:
4.) Medical Significance:

Answer 7

1.) Transmembrane Protein:
- Integrins

2.) Cytoskeleton:
- Intermediate Filaments

3.) Function:
- attach the epithelial cells to the basal lamina

4.) Medical Significance:
- blistering skin disorder

Question 8

Gap Junction
1.) Transmembrane Protein:
2.) Cytoskeleton:
3.) Function:
4.) Medical Significance:

Answer 8

1.) Transmembrane Protein:
- Connexin

2.) Cytoskeleton:
- none

3.) Function:
- cellular communication

4.) Medical Significance:

Question 9

Name 3 anchoring junctions

Answer 9

Adherens Junction
Desmosomes
Hemidesmosomes