Flashcards in Topic 5 - Disorders of blood flow Deck (10):
Types of lipoproteins
VLDL - Carries lots of triglycerides
LDL - Main carrier of cholesterol
HDL - 50% protein
240+mg/dL serum cholesterol levels
Possible causes of atherosclerosis
Endothelial dysfunction - chemical irritants, haemodynamic stress (High BP).
The fate of an atherosclerotic plaque
Stable plaque - small lipid pool with fibrous cap
Vulnerable plaque - large lipid pool, thin fibrous cap, many inflammatory cells, can rupture -> thrombus.
Sudden vessel obstruction - Acute myocardinal infarction
Aneurysm due to weak vessel wall.
Atherosclerosis risk factors
Hypercholesterolemia, smoking, hypertension, obesity, diabetes mellitus, Age.
HDL less than 40mg/dL.
Family Hx - premature CHD 1st degree relative.
C-reactive protein levels, Homocycteine levels
Formation of fibrofatty lesion in the inside lining that fills and stiffens larger and medium sized arteries.
Limb ischemia - Pain, cramping, paraesthesia, cold sensitivity, motor weakness, loss of peripheral pulses, cool skin, pallor/cyanosis distal to obstruction.
Necrosis and gangrene, angina.
Hypertension, dislodged thrombus, stroke, pulmonary embolism, development of aneurysm, ischemic heart disease, heart attack, peripheral vascular disease, erectile dysfunction.
Fever, myalgia (muscle pain), Arthralgia (joint pain), malaise.