Topic 5 - Disorders of blood flow Flashcards Preview

Pathophysiology for physiotherapy > Topic 5 - Disorders of blood flow > Flashcards

Flashcards in Topic 5 - Disorders of blood flow Deck (10):
1

Types of lipoproteins

Chylomicrons -
VLDL - Carries lots of triglycerides
IDL -
LDL - Main carrier of cholesterol
HDL - 50% protein

2

Hypercholesterolemia diagnosis

240+mg/dL serum cholesterol levels

3

Possible causes of atherosclerosis

Endothelial dysfunction - chemical irritants, haemodynamic stress (High BP).

4

The fate of an atherosclerotic plaque

Stable plaque - small lipid pool with fibrous cap
Vulnerable plaque - large lipid pool, thin fibrous cap, many inflammatory cells, can rupture -> thrombus.
Sudden vessel obstruction - Acute myocardinal infarction
Aneurysm due to weak vessel wall.

5

Atherosclerosis risk factors

Hypercholesterolemia, smoking, hypertension, obesity, diabetes mellitus, Age.
HDL less than 40mg/dL.
Family Hx - premature CHD 1st degree relative.
C-reactive protein levels, Homocycteine levels

6

Define atherosclerosis

Formation of fibrofatty lesion in the inside lining that fills and stiffens larger and medium sized arteries.

7

Atherosclerosis manifestations

Limb ischemia - Pain, cramping, paraesthesia, cold sensitivity, motor weakness, loss of peripheral pulses, cool skin, pallor/cyanosis distal to obstruction.
Necrosis and gangrene, angina.

8

Atherosclerosis complications

Hypertension, dislodged thrombus, stroke, pulmonary embolism, development of aneurysm, ischemic heart disease, heart attack, peripheral vascular disease, erectile dysfunction.

9

Vasculitis manifestations

Fever, myalgia (muscle pain), Arthralgia (joint pain), malaise.

10

Acute arterial occlusion manifestations

Pistolshot (sound of blood in vessel)
Pallor
Polar (cold)
Pulselessness
Pain
Parasthesia
Paralysis