Topic 6 Flashcards
What are chromosomes?
Really long molecules of DNA
What does DNA stand for?
deoxyribonucleic acid
What is deoxyribonucleic acid?
It’s the chemical that all of the genetic material in a cell is made up from.
What does DNA contain?
Coded information - basically all the instructions to put an organism together and make it work.
What does your DNA determine?
What inherited characteristics you have.
Where is DNA found?
In the nucleus of plant and animal cells.
What is DNA?
DNA is a polymer made up of two strands coiled together in the shape of a double helix.
What is a gene?
A small section of DNA found on a chromosome.
What are each gene coded for?
To make a particular sequence of amino acids which are put together to make a specific protein.
What do genes tell cells?
In what order to put amino acids together.
What is genome?
Just a fancy term for the entire set of genetic material in an organism.
How can understanding the human genome be an important tool for science and medicine?
1)It allows scientists to identify genes in the genome that are linked to different types of disease.
2)Knowing what genes are linked to inherited disease could help us to understand them better and could help develop effective treatments for them.
3)Scientists can look at genomes to trace migration of certain populations of people around the world.
What is DNA made up of?
Nucleotides
What are Nucleotides?
Polymers made up of lots of repeating units.
What does each Nucleotides consist of?
1 sugar molecule, 1 phosphate molecule and 1 ‘base’
Explain the structure of each Nucleotide?
The sugar and phosphate molecule in the nucleotides form a ‘backbone’ to the DNA strands. The sugar and phosphate molecules alternate. One of four different bases joins to each sugar.
What are the types of bases?
A,T,C and G
What does each base link to?
A base on the opposite strand of the helix.
What is complementary base pairing?
When A always pairs up to T and C always pairs up with G.
What does the order of bases in a gene decide?
The order of amino acids in a protein.
What are amino acids joined together to make?
Various proteins
What is the role of the non-coding parts of DNA?
To switch genes on and off, so they control weather or not a gene is expressed (used to make a protein).
What does the mRNA carry?
The code to the ribosomes.
Where are proteins made?
In the cell cytoplasm on tiny structures called ribosomes.
What do ribosomes use to make protein?
Use the code in the DNA. This is done by using a molecule called mRNA.
How is the molecule called mRNA made?
By coping the code from DNA
What does the mRNA do?
Acts as a messenger between the DNA and ribosomes - it carries the code between the two.
What are a few examples of protein?
1)Enzymes - acts as a biological catalyst to speed up chemical reactions in the body.
2)Hormones - used to carry messages around the body.
3)Structural proteins - are physically strong.
What are mutations?
A random change in an organisms DNA.
What do mutations change?
The sequence of DNA bases in a gene, which produce a genetic variant (a different form of the gene).
Do mutations effect proteins?
Most mutations have very little or no effect on the protein. Some will change it to such a small extent that its function or appearance is unaffected.
When do mutations effect proteins?
1)If the shape of an enzyme’s active site is changed, its substrate may no longer be able to bind to it.
2)Structural proteins like collagen could lose their strength if their shape is changed, making them pretty useless at providing structure and support.
What are examples of different types of mutations?
1)Insertions
2)Deletions
3)Substitutions
What are Insertions?
Insertions are where a new base is inserted into the base sequence where it shouldn’t be.
What does an Insertion definitely change?
Changes the way groups of three bases are ‘read’. which can change the amino acids they code for?
What can an Insertion change?
Can change more then one amino acid as they have a knock on effect on the bases further on in the sequence.
What are Deletions?
When a random base is deleted from the DNA base sequence.
How are Deletions similar to Insertions?
They both change the way that the base sequence is ‘read’ and have knock on effects further down the sequence.
What are Substitutions?
Substitutions mutations are when a random base in the DNA base sequence is changed to a different base
What is sexual reproduction?
Is where genetic information from two organisms is combined to produce offspring which are genetically different to either parent.
In sexual reproduction what does the mother and father produce?
gametes by meiosis
What do gametes contain?
23 chromosomes - half the number of chromosomes in a normal cell.
What does sexual reproduction involve?
The fusion of male and female gametes because there are two parents, the offspring contains a mixture off the parents’ genes.
In sexual reproduction why does the offspring inherit features from both parents?
It received a mixture of chromosomes from its mum and its dad (its the chromosomes that decide how you turn out).
What does asexual reproduction produce?
Genetically identical cells
What is asexual reproduction involve?
(there’s only one parent.) There is no fusion of gametes, no mixing of chromosomes and no genetic variations between parents and offspring so the offspring are genetically identical to the parent - they’re clones.
How does asexual reproduction happen?
By mitosis - an ordinary cells makes a new cell by dividing in two.
What is a clone?
When a new cell has exactly the same genetic information as the parent cell.
What are examples of things that reproduce asexually?
Bacteria, some plants and some animals.
How are gametes produced?
Cells dividing by meiosis
What happens after two gametes have fused during fertilisation?
The resulting new cell divides by mitosis to make a copy of itself
Why does mitosis repeat many times?
To produce lots of new cells in an embryo.
What happens when mitosis repeats many times to produce lots of new cells in an embryos?
The embryo develops, these cells then start to differentiate into the different types of specialised cell that make up a whole organism.
What can a variation of offspring increase?
Increases a chance of a species surviving a change in environment.
What is an advantage of sexual reproduction over asexual reproduction?
Offspring from sexual reproduction have a mixture of two sets of chromosomes. The organism inherits genes from both parents which produces variation in the offspring. Variation increases the chance of species surviving a change in the environment.
What is an advantage of asexual reproduction over sexual reproduction?
There only needs to be one parent this means that asexual reproduction uses less energy than sexual reproduction, because organisms don’t have to find a male. This also means asexual reproduction is faster.
What are some organisms that reproduce both ways?
1)Malaria
2)Many species of fungus
3)Loads of species of plants
What do chromosomes control?
Whether you’re male or female
How many pairs of chromosomes are there in every human body cell?
23 pairs
Out of the 23 pairs of chromosomes what does each chromosome control?
22 pairs control your characteristics and the 23rd ladled XX or XY decide your sex.
What chromosomes do males and females have?
Males have XY chromosomes and females have XX chromosomes
When making sperm cells what happens to the X and Y chromosomes?
They are drawn apart in the first diversion of meiosis. There’s a 50% chance each sperm cells gets a X or Y chromosome.
What do genetic diagrams show?
1)The possible gamete combinations.
2)The possible alleles of offspring.
How do you find the probability of getting a boy or girl?
Drawing a genetic diagram
How are most characteristics controlled?
By several genes interacting
What is alleles?
When all genes exist in different versions.
How are alleles represented?
By letters in genetic diagrams
How many versions (alleles) of every gene are there in your body?
Two - one on each chromosome in a pair
What is homozygous?
If an organism has two alleles for a particular gene that are the same then it is homozygous for that trait.
What is heterozygous?
If an organism has two alleles for a particular gene that are the different then it is heterozygous.
What happens when the two alleles are different?
Only one can determine what characteristics are present.
What is the dominant allele?
The allele for the characteristics that’s shown.
What are the two types of alleles?
Dominant and recessive
What must happen for an organism to display a recessive characteristic?
Both alleles must be recessive
What must happen for an organism to display a dominant characteristic?
The organism can be either because the dominant allele overrules the recessive one if the plant animal or organism is heterozygous.
What is your genotype?
The combination of alleles you have
What is your phenotype?
When your alleles work work at a molecular level to determine what characteristics you have.
What is cystic fibrosis caused by?
A recessive allele
What is cystic fibrosis?
A genetic disorder of the cell membrane.
What is the allele that causes cystic fibrosis?
A recessive allele, carried by about 1 person in 25.
How does cystic fibrosis effect the body?
It results in the body producing a lot of thick sticky mucus in the air passages and in the pancrease.
How does a child get cystic fibrosis?
If both parents are carries or have the disorder themselves.