Tox Deadely 12 Flashcards Preview

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Flashcards in Tox Deadely 12 Deck (12):
1

Arsenic

- CCA treted wood
- arsenic
- all spp.

- ⛔️kreb cycle ➡️ vasc perm
- GI signs
-🎖uncoup ox phos➡️sudden death

-RSS succimer💊

2

Blister 🐞🎖

- alfalfa hay
- canthardin
- 🐄🐎

- vesicant➡️ulceration: colic
⬇️Ca/Mg, colic, THUMPS
- hemorrhagic cystitis

- RSS

3

Cu

- non-ovine feeds
- Cu
- 🐑

- accum Cu in liver➡️ hepatocell necrosis
- oxid damage, hemolysis, anemia, Hgb-uric nephrosis ☠️

-RSS

4

EG

- antifreeze
- glycolate, oxalate
- all spp

- cytotoxic metabolics➡️❤️ and neuro signs
- 🎖ataxia, PU/PD, Ca oxalate nephrosis

- RSS, ethanol, 4methylprazole

5

Ionophores 🎖

- cocciostat 🐓 feed
- monesin
- 🐎🐄 🐖🐕 🚫🐱

- ⛔️ATP Hydrolysis: ⬆️intra Ca
-💔 necrosis➡️☠️

-RSS

6

Methylxanthines 🍫

- 🍫☕️🍵
- theobromine, caffine, theophylline
- 🐶

- ⛔️cyclic nucleotide PDE
⛔️ GABA/adenosine-R
Chatechol rel: Hyperexcitability ➡️☠️
- bouncing dog synd/ 🎖❤️arrhythmias

- RSS Ucath, actv charcoal

7

Lead

- batteries, paint
- lead
- all spp, esp growing

- ⛔️enzymes
- mimics [Ca]
heme synthesis
- 🐄 blindness/PEM/GI signs
🐶 ⬇️hematopoesis
🐎 PNS.
- RSS chelate/thoamine

8

NPN/urea 🎖

- Ru feed additive
-NH3
- Ru

-🚫NaK ATPase/kreb
- Rumen ALK ➡️ m.acidosis; bloat, salivation,
🎖hepatoencephalopathy-like effects

- RSS cold water, vinegar 💦

9

Acetaminophen

-💊 tyelenol
-NAPQI
-🐱

- oxidative damage RBC ➡️ methHgb
- facial/paw edema, hepatocellular necrosis

-RSS, N-acetylcysteine

10

OP

- insecticides
- AchE i
- all spp

- inhibiton AchE
- SLUDD

- RSS atropine

11

Rodenticides

- anticoag/bromethalin/cholecalciferol
- all spp, 🐶

- ⛔️vit K epoxide rductase: ⬇️vit K CF ➡️blood loss anemia, hypoxia, death
Uncouples ox phosphorylation: CNS sign
⬆️⬆️⬆️ Vit D activit: ST mineralization

- RSS, Vit K, plasma transfusion

12

Zinc

- post 1982 penny
- Zn
- all spp

- oxid damage RBC ➡️ hemolysis
- hypoxia/🎖Hgb nephrosis

- RSS