Toxico Flashcards
1
Q
What is the first pass effect
A
If a drug is subject to high hepatic clearance (as it passes thru this first before systemic circulation) a substantial fraction will be extracted from the portal blood and metabolized before it receaches systemic circulation
2
Q
What catalyzes the first pass effect
A
Chytochromes P450
3
Q
What does LD50 mean
A
represents the concentration of dose required to kill half the members of a tested population
4
Q
What is the therapeutic index
A
quantitative measurement of the relative safety of a drug
5
Q
what is the therapeutic window
A
refers to a range of doses which optimize between efficacy and toxicity
