Toxicology

Question 1

Sodium Valproate Toxicity

Answer 1

400mg/kg multisystem effects, potentially lethal >1g/kg
drowsiness, CNS depression- coma requiring intubation, airway compromise, cerebral oedema, hypotension, lactic acidosis, low BGL, hyperammonaemia, hypernatraemia, hypocalcaemia, bone marrow suppression

Sodium valproate levels- serial, UEC, VBG, FBC, paracetamol level, ECG

Intubation early, / whole bowel irrigationcharcoal post intubation, haemodialysis prior to multi organ dysfunction,