Toxicology

Question 1

Benzodiazepine

Answer 1

Flumazenil

Question 2

Heparin

Answer 2

Protamine sulfate

Question 3

Iron

Answer 3

Deferroxamine

Question 4

Opiod / Narcotic

Answer 4

Naloxone

Question 5

Acute Mercury Poisoning

Answer 5

Dimercaprol

Question 6

Wilson’s Disease

Cu metabolism

Answer 6

Penicillamine

Question 7

Chronic Mercury Poisoning condition

Answer 7

Minamata Disease

Question 8

Lead

Answer 8

EDTA

Dimercaprol

Question 9

Arsenic

Answer 9

Dimercaprol

Question 10

Organophosphate
Insecticide (Malathion, Parathion)

Acute

Answer 10

Pralidoxime

reverses both PNS (paralysis) and CNS but at acute cases only

Question 11

Organophosphate

Insecticide (Parathion/Malathion)

Chronic

Answer 11

Atropine

CNS effects but can’t reverse paralysis

Question 12

Acetaminophen

Paracetamol

Answer 12

N Acetylcysteine

Question 13

Acetaminophen Paracetamol Toxicity causes

Answer 13

Centrilobular
Hepatic
Necrosis

Question 14

Isoniazid INH

Answer 14

Pyridoxime B6

Question 15

Sodium Nitroprusside condition

Answer 15

Cyanide / Thiocyanate Toxicity

Question 16

Sodium Nitroprusside Antidote

Answer 16

Sodium Thiosulfate

Question 17

Blockade of Complex IV ETC

Cytochrome oxidase

Answer 17

Cyanide Toxicity

Question 18

Fibrinolytic toxicity

Answer 18

Aminocaproic acid

Tranexamic acid

Question 19

Digoxin Induced Arrhythmia

Answer 19

Lidocaine

Question 20

Beta Blocker overdose

Answer 20

Glucagon

Question 21

Sufonylurea overdose

Answer 21

Ocreotide

Question 22

Clonidine overdose

Answer 22

Naloxone

Question 23

Calcium channel blocker overdose

Answer 23

Glucagon

Question 24

Valproic acid

Answer 24

Carnitine

Question 25

Aspirin (Salicylate)overdose

Answer 25

Sodium bicarbonate

Question 26

Wernicke’s encephalopathy

Answer 26

Thiamine

Question 27

Korsakoff’s

Answer 27

Thiamine

Question 28

Methanol

Answer 28

Ethanol

Question 29

Ethylene glycol

Answer 29

Fomepizole | Ethanol

Question 30

Fomepizole

Answer 30

Competitive inhibitor of alcohol dehydrogenase

Question 31

Methotrexate

Answer 31

Leucovorin | Folinic Acid

Question 32

Alcohol dehydrogenase

Answer 32

Catalyzes oxidation of ethanol to acetaldehyde

Question 33

Malignant hyperthermia

Answer 33

Dantrolene

Question 34

Cyclophosphamide ifosfamide side effect

Answer 34

Hemorrhagic cystitis

Question 35

Cyclophosphamide ifosfamide metabolite

Answer 35

Acrolein

Question 36

Cyclophosphamide toxicity

Answer 36

MESNA Mercaptoethane sulfonate

Question 37

Doxurubicin | Daunorubicin

Answer 37

Cardiotoxicity

Question 38

Doxurubicin antidote

Answer 38

Dexrazoxane

Question 39

Most cardiotoxic local anesthetic

Answer 39

Bupivacaine

Question 40

Theophylline Caffeine

Answer 40

Esmolol

Question 41

Atropine

Answer 41

Physostigmine

Question 42

Magnesium sulfate toxicity happens in

Answer 42

eclampsia

Question 43

Magnesium sulfate symptoms

Answer 43

BURP decrease BP decrease Urine output decrease Respiratory rate Absent patellar ref

Question 44

Magnesium sulfate toxicity

Answer 44

Calcium gluconate

Question 45

Anaphylactic shock

Answer 45

Epinephrine 0.5-1 ml 1:1000 dilution SQ

Question 46

Triad of Opiod Overdose

Answer 46

Respiratory failure Miosis Coma

Question 47

British Anti Louisite moa

Answer 47

Neutralizes heavy metals and promotes its elimination

Question 48

EDTA (Ethylene Diamine Tetraacetic Acid) MOA

Answer 48

chelates Ca and metal ions

Question 49

Organophosphate Poisoning sx

Answer 49

``` Hypersecretion Hypermotility Bradycardia Miosis DUMBBELS ```

Question 50

Isoniazid Metabolite

Answer 50

Acetylhydrazine

Question 51

Acetaminophen toxic dose

Answer 51

7-10 g

Question 52

Acetaminophen toxicity causes depletion of

Answer 52

glutathione

Question 53

Acetaminophen metabolite

Answer 53

NAPQB1 | N acetyl P benzoquinoneimine

Question 54

Chloroform toxicity (pathologic finding)

Answer 54

Centrilobular hepatic necrosis

Question 55

Acetylcysteine MOA

Answer 55

regenerates Glutathione

Question 56

DOG for Acromegaly

Answer 56

Ocreotide

Question 57

Aspirin (Salicylate) Toxicity Sx

Answer 57

Initial Respiratory Alkalosis (Hyperventilation) Anion Gap Metabolic Acidosis Tinnitus Hyperthermia

Question 58

Aspirin Toxic Dose

Answer 58

>10g

Question 59

Methanol Toxic dose

Answer 59

>15 ml

Question 60

Methanol overdose sx

Answer 60

CNS Depression Wide anion gap acidosis Optic disc hyperemia Blindness

Question 61

Methanol Overdose Eye Pathologic Symptom

Answer 61

Snowstorm Vision

Question 62

Mediates doxurubicin daunorubicin toxicity

Answer 62

Topoisomerase IIB

Question 63

Side effect of methamphetamine

Answer 63

Dilated cardiomyopathy

Question 64

Drug of Choice for Intraoperative Arrhythmia

Answer 64

Esmolol

Question 65

Metabolite of catecholamine

Answer 65

Vallenylmandelic acid

Question 66

Metabolite of serotonin

Answer 66

5 hydroxyindole acetic acid

Question 67

Drugs that induce abnormal RBC production (DNA synthesis) 3

Answer 67

Methotrexate Pyrimethamine Trimethoprime

Question 68

12 - 24h after iron supplement, it is expected that

Answer 68

Intracellular iron enzyme replaced | Inc appetite

Question 69

36-48h iron supplement, it is expected that

Answer 69

Initial B response | Erythroid hyperplasia

Question 70

48 - 72h post intake of iron

Answer 70

Reticulocytosis peaking 5-7 days

Question 71

4-30 days post iron intake

Answer 71

Inc Hgb level

Question 72

1-3 mo post iron intake

Answer 72

Repletion of store

Question 73

Major thalassemia drug

Answer 73

5-Azacytidine

Question 74

Drugs that induce hemolysis (4)

Answer 74

Aspirin Rasburicase Sulfonamide Primaquine (antimalarial)

Question 75

Severe digitalis toxicity

Answer 75

Digibind fab frag

Question 76

Group 1A anti arrhythmic tox

Answer 76

sodium lactate, vasopressor