Cholinomimetics

Question 1

M1 receptor organs

Answer 1

Nerve, CNS

Question 2

M2 receptor organs

Answer 2

Heart and smooth muscle

Question 3

M3 receptor organs

Answer 3

Endothelium, bladder GI, eye

Question 4

M1 receptor and 2nd messenger

Answer 4

Gq

IP3 DAG

Question 5

M2 receptor and 2nd messenger

Answer 5

Gi

dec cAMP

Question 6

M3 receptor and 2nd messenger

Answer 6

Gq IP3 DAG

Question 7

Nicotinic receptor organs

Answer 7

NMJ, Skeletal ms, adrenal glands, autonomic ganglia

Question 8

Direct acting acetylcholine receptor agonists (2)

Answer 8

Esters

Alkaloids

Question 9

Indirect acting binding to acetylcholinesterase (2)

Answer 9

Reversible

Irreversible

Question 10

Muscarinic agonist, negligible nicotinic effect

Answer 10

Bethanecol

Question 11

Muscarinic agonist for all receptors for post op ileus and urinary retention

Answer 11

Bethanecol

Question 12

Muscarinic and nicotinic agonist for glaucoma

Answer 12

Carbachol

Question 13

Bethanecol and carbachol SE

Answer 13

bronchospasm

mydriasis

Question 14

Partial muscarinic agonist for Glaucoma and Sjogrens

Answer 14

Pilocarpine

Question 15

Direct acting muscarinic agonist For asthma testing

Answer 15

Methacoline

Question 16

Methacoline SE

Answer 16

PUD, bronchospasm

Question 17

Agonist at Nn & Nm receptors activating sympathetic and parasympathetic effects

Answer 17

Nicotine

Question 18

Selective nicotinic partial agonist for smoking

Answer 18

Varenicline

Question 19

Acetylcholinesterase inhibitor with short duration of action for DX of myesthenic and cholinergic crisis

Answer 19

Endrophonium

Question 20

Other name endrophonium

Answer 20

Tensilon test

Question 21

Covalently bonds to acetylcholinesterase to hydrolyze and release Ach but with longer acting effect for myesthenia gravis

Answer 21

Neostigmine

Question 22

Acetylcholinesterase inhibitor also used for post operative neurogenic ileus, urinary retention and antagonist for NM blockade drugs

Answer 22

Neostigmine

Question 23

Longer acting 4-6h anticholinesterase for MG

Answer 23

Pyridostigmine

Question 24

Alkaloid anticholinesterase that can cross BBB

Answer 24

Physostigmine

Question 25

Why can physostigmine cross BBB and the 3 others can’t

Answer 25

It is a tertiary amine while | others are quarternary

Question 26

Anticholinesterase inhibitors that can enter CNS but also treats glaucoma

Answer 26

Echothiophate

Question 27

Causes excessive muscarinic and nicotinic sx

Answer 27

Organophosphates (malathione, parathion, sarin)

Question 28

Regenerates acetylcholineste at NMJ relieves peripheral sx of organophosphate tox but cannot cross BBB

Answer 28

Pralidoxime

Question 29

Organophosphate poisoning antidote that crosses BBB

Answer 29

Atropine

Question 30

Organophosphate toxicity (sx)

Answer 30

DUMBBELS

Question 31

Acetylcholinesterase inhibitors used for Alzheimer (3)

Answer 31

Donapezil Rivastigmine Galantamine

Question 32

Acetylcholinesterase given as patch for Alzheimers

Answer 32

Rivastigmine