TPN Flashcards

(44 cards)

1
Q

define malnutrition

A

deficiency/excess/imbalance of energy/proteins/other nutrients causing adverse effects on the body

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2
Q

what can malnutrition cause

A

impaired immunity decreased wound healing increased complications poor response to therapy (3x more likely to have complications) reduced growth/development death

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3
Q

what is acute malnutrition

A

develops rapidly in the presence of acute stress/injury

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4
Q

what is chronic malnutrition

A

develops in a number of disease states but requires long term monitoring and therapy

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5
Q

if a patient has Inadequate or unsafe oral intake but a Functional, accessible GI tract which feeding method would you use

A

enteral feeding tube

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6
Q

if a patient has Inadequate or unsafe oral intake but a non-functional, accessible GI tract which feeding method would you use

A

parenteral nutrition (IV)

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7
Q

what is parenteral nutrition

A

IV administration of nutritionally balanced, physiochemical, stable and sterile combination of water and nutrients

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8
Q

what makes up parenteral nutrition

A

wateramino acids glucose lipids vitamins trace elements electrolytes

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9
Q

maintenenace water requirements in PN

A

1500ml + 20ml/kg >20kg

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10
Q

causes of dehydration/increased fluid requirements with PN

A

fever, GI loss, blood loss and burns

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11
Q

causes of fluid overload/decreased fluid requirements with PN

A

blood transfusion, drugs, renal/cardiac failure

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12
Q

how much of your bw is made up of water

A

60%

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13
Q

nitrogen requirements in PN

A

0.2g/kg/day

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14
Q

when would more amino acids be required in PN

A

diseased/clinically stressed states

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15
Q

what are the amino acid requirements

A

20 in total, 8 cannot be synthesised and 5 conditionally essential

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16
Q

warning with TV amino acid administration

A

hypertonic - should not be administered alone

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17
Q

what affects energy requirements

A

age, activity, disease severity

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18
Q

what are the energy requirements

A

25-35 non-protein kcal/kg/day

19
Q

why should glucose not be given alone

A

hyperglycaemia fatty infiltration of liver excessive co2 production and o2 consumption essential fatty acid deficiency

20
Q

energy content of glucose

A

1g anhydrous glucose = 4kcal

21
Q

energy content of lipids

A

10kcal/g of oil

22
Q

lipid requirements

23
Q

which acids contain essential fatty acids

A

linolenic and linoleic acids

24
Q

what are the fat soluble vitamins

25
what are water soluble vitamins
B1, B2, B6, B12, C, folic acid
26
why are vitamins important
play a key role in intermediary metabolism as co-factors and co-enzymes
27
in which diseases would you need altered vitamin requirements
□ Small bowel fistulae - decreased zinc □ Biliary fluid loss - decreased copper □ Burns - decreased zinc, copper and selenium □ Liver failure - copper and manganese clearance reduced □ Renal failure - aluminium, chromium, zinc and nickel clearance reduced
28
what are the 10 known trace elements required in PN
iron copperzinc fluorine manganese iodine cobalt selenium molybdenum chromium
29
which electrolytes are required in PN
sodiumpotassium calcium magnesium phosphate chloride acetate
30
what are the two reasons a patient may need TPN
- short term inpatient (NMB/obstruction or malnourished) - long term/home (non-functioning gut)
31
what are the two methods for TPN administration
peripheral administration (PICC) - 1st line central line
32
indications for a PICC line
short term supplemental feeding high sepsis risk no immediate central line access
33
feed requirements via PICC line
good line care and low tonicity feeds (<800mOsmol/L)
34
C/I for PICC lines
inaccessible peripheral veins high PN osmolality (high calorie/nitrogen content)
35
how do central lines work
put into subclavian vein or jugular vein - must be confirmed via x ray
36
indications for central lines
longer term feeding inaccessible peripheral feeding higher tonicity formulations (>2000mOsmol/L)
37
what are some pharmaceutical issues with TPN
physical stability, chemical stability and microbial stability
38
issues with physical stability with TPN bags
precipitation not seen in bags containing lipids - can cause embolism lipid destabilisation - coalescence occluding microvasculature - all PN fluids passed through filter before infusion
39
issues with chemical stability with TPN bags
vitamins undergo chemical degradation - all bags must be protected from light
40
issues with microbial stability with TPN bags
lots of nutrients - good for bacterial growth - use aseptic techniques
41
monitoring requirements with TPN
- ongoing requirements - complications - clinical symptoms: temp, bp, fluid, weight - lfts/electrolytes/bm/crp- calcium and albumin
42
complications with TPN
- line blockages (tip, blood/drug clot, line kinking) - line sepsis - thrombophlebitis - refeeding syndrome
43
what is refeeding syndrome
when infused nutrition exceeds tolerance of previously malnourished patient - can cause sudden insulin production
44
how to avoid refeeding syndrome
start feeding slowly - over 48 hours add thiamine if at risk