Trachte: Adrenergic Agonists Flashcards Preview

CRAAB 6 > Trachte: Adrenergic Agonists > Flashcards

Flashcards in Trachte: Adrenergic Agonists Deck (55):
1

What is NE synthesized from?

Tyrosine

2

What acts on B1 receptors?

Isoproterenol> Epi = NE

3

Where are B1 receptors located?

Heart
JG apparatus
Adipose tissue

4

What does stimulation of B1 receptors lead to?

Galpha>
increase cAMP>
adrenergic cardiac effects, renin release

5

What acts on A1 recetpors?

Epi> NE>> Iso

6

Where are A1 receptors located and what do they do?

blood vessels>
Smooth muscle contraction

7

What g protein are A1 receptors coupled to?

Galpha a>
phospholipiase C>
inositol triphosphates>
increase intracellular CA

8

What acts on B2 receptors?

iso> epi>> NE

9

What does stimulation of B2 receptors do?

relax smooth muscle
metabolic effects

10

Where are B2 receptors located?

Blood vessels (smooth muscle)

11

What G protein are B2 receptors coupled with?

G alpha s>
increase c AMP

12

What acts on A2 receptors?

Epi> NE>> Iso

13

What does stimulation of A2 receptors do?

Inhibits NE release

14

Where are A2 receptors locate?

Prejunctional nerve terminal, platelets, gut, medulla oblongata

15

How do A2 receptors decrease cAMP?

G aplha i>
decrease cAMP or activate Na/H antiporter

16

What do dopaminergic receptors interact with? What does this do?

DA

dilate renal and mesenteric vasculature

17

What is Dobutamine?

B1 agonist

18

What does Dobutamine do to blood pressure and what will block that effect?

INCREASE BP
Blocked by propranolol

19

What is dobutamine used for?

CHF
AMI w/ heart failure

20

What is phenylphrine?

alpha 1 agonists

21

What is phenylphrine used for?

reverse hypotension
paroxysmal atrial tachycardia

22

What is used to treat orthostatic hypotension?

Midodrine

23

What does phenylphrine do to blood pressure? What blocks it?

Increases blood pressure
Blocked by Terazosin

24

What receptor does Metaprotenrenol, Terbutaline, Albuterol and Salmeterol act on?

B2 selective agonist

25

What is albuterol used for?

Bronchodilation

Asthma- B2 agonists

26

What drugs are used to delay labor?

ritodrineterbutaline

27

What are side effects of B1 stimulatoin

Tachycardia, palpitations

28

What are side effects of B2 stimulation?

tremor and headache

29

What is the major cardiovascular effect to iv injection of a B2 selective agonist?

Vasodilation

30

What does albuterol do to blood pressure? What would block that action?

Decreases blood pressure
Propranolol

31

Whatare Clonidine, methyldopa, guanabenz and tizanidine?

A2 agonists

32

What is an antihypertensive that's safe to use in pregnancy?

Methyldopa

33

What drugs decrease sympathetic activity without interfering with reflexes?

Guanabenz, Guanfacine

34

What is clonidine used for?

ADD

35

What are side effects of A2 receptor agonists?

Depression
Sexual dysfunction
Dry mouth
bradycardia

36

What do alpha 2 agonists do to blood pressure?

Increase blood pressure

37

What happens when Epi stimulates A1 vs B2?

A1- vasoconstricts
B2- vasodilate

38

What does Epi do in the cardiovascular system?

INCREASES HR and force but reflexes to elevation in BP can suppress HR (vagal stimulation)

39

What does Epi do to blood pressure?

Increases blood pressure

40

What happens when EPI is blocked by terazosin?

Brings blood pressure back to normal

41

What happens if you give Epi and terazosin?

Decrease BP

42

What happens when you give epi after giving terazosin and propranolol?

BP stays the same

43

What does NE do?

A1- vasoconstriction
B1- increase heart rate and force

(reflex reduction in HR--mediated by vagus nerve)

44

What does NE do to bp?

Increases BP

45

What happens if you administer NE after giving terozosin?

Smaller increase in BP

46

What happens if you give NE after giving terazosin and propranolol?

Bp stays the same

47

What does isoproternol do?

B2- vasodilation
B1- tachycardia

48

What is isoproterenol used for?

B1 cardiac stimulation

49

Stimulation of what receptor increases CO?

B1

50

Stimulation of what receptor increases TPR?

B1, A1

51

Stimulation of what receptor decreases HR?

Muscarinic

52

Stimulation of what receptor decreases TPR?

Muscarinic and B2

53

What does affect does dopamine have on B1, dopaminergic, A1 and the neural system?

B1- positive ionotrope
Dopaminergic- vasodilator of renal and mesenteric vasculature
A1- vasoconstrictor at high doses
Neural- releases NE from nerves

54

What is DA used for?

Maintains renal perfusion
Hypotension
Increased BP and CO

55

What do indirectly acting agents (like NE and Amphetamine) do?

Release NE from nerves by reversing the catecholamine axoplamic uptake pump>
increases BP