Tramadol

Question 1

MoA

Answer 1

Transom is an analgesic. it has multiple actions with the central nervous system, including opiate receptor stimulation and inhibition of the re-uptake of noradrenaline and serotonin.

Question 2

Indications

Answer 2

Moderate to severe pain. Particularly if an opiate and/or ketamine is not going to be administered.

Question 3

Contraindications

Answer 3

Known Severe allergy.

Aged less than 12 years

Question 4

Cautions

Answer 4

• Taken within the last 4 hours.
• Abdominal pain. particularly if the patient is unwell and/or vomiting.
• aged >75 years particularly if there is a history of confusion or dementia.
• Confusion. Tramadols antichlolinergic activity may worsen confusion.
• pregnancy, should usually be withheld

Question 5

Dosage

Answer 5

50mg PO

Question 6

Onset and Duration

Answer 6

30-60 minute onset

4 - 8hr duration

Question 7

Adverse affects

Answer 7

Nausea and/or vomiting

lightheadedness or feeling unusual

Sedation

dry mouth

Question 8

Pharmacokinetics

Answer 8

metabolised in the liver and excreted by the kidneys

Question 9

Common interactions

Answer 9

can cause serotonin syndrome when administered in combination with other serotonin increase recreational or prescribed drugs. e.g. tricyclics, ecstasy.