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Drug Monographs - APR 23 > tranexamic acid > Flashcards

tranexamic acid Flashcards

1
Q

Classification

TXA

A
  • haemostatic
  • antifibrinolytic agent
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2
Q

Pharmacodynamic

TXA

A
  • prevents clot degradation by competing for TPA receptor sites
  • inhibits plasminogen conversion to plasmin
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3
Q

Pharmacokinetics

TXA

A 
IV
 onset - immediate
 peak - 3hrs
 duration - 3hrs
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4
Q

INDICATIONs

TXA

A

[PCP]
- signs of shock // hypotension - assoc. w/ injury suggestive of occult or ongoing bleeding

cliniCALL required
maternal vaginal hemorrhage >19 weeks // postpartum hemorrhage

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5
Q

CONTRAINDICATIONs

TXA

A
  • HYPERSENSITIVITY
  • TIME since injury >3HRs
  • GI bleed
  • Not for actual/estimated age <12
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6
Q

ADVERSE EFFECTs

TXA

A
  • if administered rapidly, may potentiate hypotension
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7
Q

Dosage - Adult

TXA

A 
[PCP]
1g IV - over 10mins

NS 50mL - 1gtts/s

NS 250mL - 5gtts/s (open)

IV USE ONLY

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8
Q

Dosage - Pediatric

TXA

A 
[PCP]
1g IV - over 10mins

NS 50mL - 1gtts/s

NS 250mL - 5gtts/s (open)

IV USE ONLY

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Drug Monographs - APR 23 (17 decks)

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