tranlecture4 Flashcards
(21 cards)
how does mydriasis from M3 inhibition differ from alpha 1 activation
with if you still have accommodation its a1 mydriasis no cycloplegia
what is the effect of aplaha one on the vas deferens
ejaculation
where are the Alpha 2 receptors
brain post synaptic organs and in the platelets and pancreas
what is dromotropy inotropy and chronotropy
conduction volocity force of contration and heart rate
what is reflex tachycardia
an decrease in BP will lead to an increase in heart rate
how does Alpha 2 agonist effect interocular pressure
decreased the production of aqueous humor
know slide the autonomic feedback loop controlling blood pressure
Slide 82
what happens when you stimulate Alpha 1 receptors or alpha 1 antigonists
reflex bradycardia or reflex tachycardia
what loop is faster acting autonomic or hormonal
hormonal feedback loop for blood pressure
how does the response change with direct acting drugs with prior treatments
because it directly acts on the receptors it is not reduced by prior treatment with reserpine or guanethidine
how does the response change with mixed acting drugs with prior treatments
ephedrine, response is reduced with prior treatment with reserpine or guanethidine but not completely abolished.
how does the response change with indirect acting drugs with prior treatments
resposnes are ablolished by prior treatment with reserpine or guanethidine
what is phenylephine or neo-synephrine
activate alpha 1 receptors on vascular muslc increasesd BP and TPR. Can activate the bet receptors only at much higher levels.clincial indications antihypotensive orthohypotensiion shock, paroxysmal atrial tachycardia [will activate the reflex loop and will cause reflex bradicardia], nasal decongestant [vasoconstiction], and mydriatic[constict the muscles in the eye].
what are he a2 selective adrenergic receptors agonists
clonidine or catapres, alpha methyldopa or aldomet, apraclonidine or lodipine, or brimonidine or alphagan
how does the clonidine or alpha methyldopa work
activate central alpha 2 receptorr lowers the central sympathetic outflow lowers the bloop pressure lowers aqueous humor production lowers intraculrar pressure used to reate systemic hypertension and gluacoma side effects inculded dry mouth sedation and hypotension
what is a metaprontenerol
beta selsevie resistant to methylation of COMT long term treatment of obstructive airway disease asthma a and acute bronchospasm
what is terbutaline
Beta 2 selective used in asthma long term obstructive airway disease acute bronchospasm
wha tis albuterol
oral use only can delay preterm labor and asthma brochospasm beta 2
what is ritodrine
uternine relacant prolong pregnacy beta 2 arrest premature labor
what are the side effects of beta 2 agonists
tachycardia increase plasma glucose lactate and free fatty acids, decrease potasium careful with those taking digoxin and diuretics because it will increase stage three due to the lower potassium but all these are much less likely with the inhalation therapy compared to the oral therapy.
what is fenoldopam
a D1 receptor agonist, some effects on alpha 2 but mostly on D1. Used in hypertensive crisis can cause hypotensive.
