Tranquilizers Flashcards Preview

Pharm Exam 2 > Tranquilizers > Flashcards

Flashcards in Tranquilizers Deck (12):
1

Tranquilization

state of behavioral change, in which the patient is relaxed, unconquered by surroundings, & often indifferent to minor pain

2

What is the goal of tranquilizers?

Alleviate anxiety w/o affecting clarity of consciousness

3

Uses of tranquilizers

• Tranquilized BEFORE handling
• Pre-anestheic
• enhance smooth recovery
• some skeletal muscle realization

4

What is the diff in true sedation vs tranquilizer?

In contrast to tranquilizers, only real sedatives at HIGH does levels cause a profound CNS depression that resemble anesthesia

Tranquilizers do NOT provide analgesia & loud noises stimulation can reverse the calming effects of the drugs

5

Phenothiazine

most commonly used tranquilizer
• blockade of effects of dopamine, by antagonizing dopamine excitatory receptors & depressing connection to the cerebral cortex

Use
• Tranquilization
• anti-emetics

6

What are undesirable side effects of phenothiazine?

• Vasodilation --> hypotension
- due to blockage of alpha-adrenergic receptors
** Do Not give Epi!!

7

Acepromazine

• Pre-medication for general anesthesia
-- Low dose
-- prevents bradycadia (w/ atropine)
• Tranquilization
-- higher dose
*** Precaution
• DO NOT use Epi
• avoid in seizure patients --> reduces threshold

8

Promazine Hydrochloride

Dogs:
• Anti-emesis (1/3 -1/2 dose used to tranqu)
• utilized in self mutilation anxiety

Horse
• Do NOT use w/ Equine COLIC (hypotension!)

9

Butyrophenones

MOA (dopamine antagonist)
• Mainly dopamine receptor blockade
--> inhibits central action of catecholamines

Side effects
• Hypotension
- less severe than w/ phenothiazine
• Do NOT use w/ Epi

10

Drugs used to restrain wild animals

Short acting
1. Azaperone
2. Haloperidol

Long acting
1. Zuclopenthixol
2. Perphenazine
3. Pipothiazine palmtate

11

Which short acting drug is used in combo w/ long acting tranquilizer?

Azaperone

12

Long acting tranquilizers

Phenothiazine derivatives
• lasts several weeks
• prolonged duration due to creation of FA ester of active drug & dissolving it in oil

**Given IM ONLY!!
• creates deposit from which drug slowly diffuses
• activation occurs in blood (ester hydrolyzed