Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Heme > Transfusion Medicine > Flashcards

Transfusion Medicine Flashcards

(62 cards)

Start Studying
1
Q

Sig anemia is considered?

A

<7 hgb

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

How old is fresh whole blood?

A

<24hr old

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Fresh whole blood provides?

A

Oxygen carrying capacity
Volume expansion
(RBCs, WBCs, PLTs, plasma)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Indications for fresh whole blood?

A

Cardiac surgery or massive bleed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Fresh whole blood requires what of a donor?

A

Exact blood match

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

MC transfused blood product is?

A

pRBCs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

1 unit pRBCs raises h/h how much?

A

Hgb - 1.0g/dL

Hct - 3-4%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

1 unit of pRBCs provides how much volume expansion?

A

300mL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is a common cause of post-transplant infection/GVH dz?

A

CMV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Benefit of filtering out WBCs from RBCs ? (Leukocyte reduced)

A

Reduces chances of forming antibodies to donor WBC’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Leukoagglutinization is?

A

Formation of antibodies to donor WBC antigens which causes febrile non-hemolytic rxn

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

CMV or Leukocyte reduced filtered RBC indications?

A

Prior febrile non-hemolytic transfusion rxn
Undergoing cardiovascular surgery
Potential transplant candidate
Chronically transfused pts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Frozen RBCs are good for?

A

Maintaining a supply of rare Blood types (expensive)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How long is frozen RBCs good for?

A

Up to 10years

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Irradiated RBC’s means?

A

WBCs are completely eliminated from RBCs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Irradiated RBC’s are reserved for?

A

Immunocompromised pts at risk of transfusion associated graft vs host Dz (TA-GVH Dz)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

TA-GVH dz occurs when?

A

Donor T-cells recognize host HLA antigens as foreign and attacks w/ immune response.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Platelet unit volume?

A

50mL/unit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

1 unit apheresis platelets equals?

A

6 units of whole blood-derived platelets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Apheresis process is?

A

Whole blood is filtered to separate a particular component

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

1 Unit of PLTs should do what to PLT count?

A

Increase it by 5-10k w/in 1hr

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Platelet refractoriness is?

A

Failure of the platelet count to rise w/in 1 hr (<5k)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Platelet refractoriness is caused by?

A 
Fever
Sepsis/Infection
Active bleeding
Splenomegaly
Alloimmunization
ABO mismatch
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

FFP is?

A

Seperated plasma from whole blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
FFP contains what?
All coagulation factors
26
FFP indications?
active bleeding or high risk of bleeding
27
I unit FFP volume expansion amount?
200-250mL
28
Cryo is essentially?
Subspecialized version of FFP w/ high concentraions of F8, F13, vWF, Fibrinogen, fibronectin.
29
Cryo volume amount?
20mL
30
Cryo indications
Replacement of coag factors esp, Von Williebrands Dz or severe DIC
31
Type and cross is tested ro avoid what?
hemolytic transfusion rxn
32
Type O donor can give blood to?
O, A, B, AB recipient
33
Type A donor can give blood to?
A, AB recipient
34
Type B donor can give blood to?
B, AB recipient
35
Type AB donor can give blood to?
AB recipient
36
Universal donor is?
O negative
37
Universal recipient is?
AB positive
38
Transfusion complication types
Non-hemolyic - febrile non-hemolytic rxn Hemolytic - acute hemolytic, delayed hemolytic rxn Blood product contamination Transfusion ass/w infections
39
MC transfusion rxn?
Febrile, non-hemolytic transfusion rxn. | leukoagglutination reaction
40
Febrile, non-hemolytic transfusion rxn physiology?
Small amounts of donor WBCs transfused into pts w/ prior sensitization. (leukoagglutination)
41
Febrile, non-hemolytic transfusion rxn presents as
MC - Mild fever and chills w/in 12hrs | Sev - Dyspnea w/ cough, pulmonary infiltrates
42
Febrile, non-hemolytic transfusion rxn occurs MC in what blood product?
pRBCs
43
What happens to H/H w/ Febrile, non-hemolytic transfusion rxn
it rises
44
TXT of Febrile, non-hemolytic transfusion rxn
Benadryl APAP CCS
45
Acute hemolytic transfusion rxn (AHTR) occurs when?
Mismatched ABO/Rh blood is given resulting in intravascular hemolysis
46
MC reason for AHTR to happen is?
Clerical error
47
AHTR severity is dependent on?
volume transfused w/ most severe usually happening during surgery under general anesthesia
48
AHTR classic S/S
Fevers, Rigors, HOTN, HA, Back pain, +- pain at site General anesthesia pts - Oliguria/generalized bld Sev - acute renal failure (ATN) circulatory shock, DIC
49
Delayed hemolytic transfusion rxn is typically delayed how long?
5-10d
50
What is the reason for the delay in -delayed hemolytic rxn- ?
less antigen/antibody response | recipient = low alloanitbody levels (not ID'd in screen)
51
Delayed hemolytic transfusion rxn results in?
less hemolytic response that occurs several days post transfusion (AKA- Anamnestic response)
52
Delayed hemolytic transfusion rxn causes what type of hemolysis?
Extravascular hemolysis (in spleen)
53
Blood product contamination is usually due to what type of organisms?
GN (can be GP however)
54
Blood product contamination usually occurs w/ what type of product?
PLT's - stored at room temperature
55
Blood product contamination rxn S/S
Septic shock, Acute DIC, Acute kidney injury due to endotoxins from organism (usually fatal)
56
MC documented organism w/ Blood product contamination?
Yersinia enterolytica
57
GP Blood product contamination S/S
fever/bacteremia - rarely sepsis
58
Transfusion ass/w infections
Hep B Hep C HTLV - (antibody to T-cell/leukemic virus) HIV
59
Massive transfusion means?
Pt received >50% of own blood volume w/in 24hrs | >10 units pRBCs w/in 24hrs
60
Massive transfusion will always require?
Plasma replacement (FFP usually), PLTs
61
Massive transfusion complications
``` Coagulopathy (req FFP/Cryo) Dilutional thrombocytopenia (req PLT's) Metabolic acidosis Hypocalcemia Hypothermia Hyperkalemia ```
62
Massive transfusion recommendation
1:1:1 FFP:pRBC:PLT

Heme (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions